6^th Global Ophthalmologists Annual Meeting May 16-18, 2016 Osaka, Japan

Biography:

Bonnie Nga Kwan Choy graduated from the Faculty of Medicine, the University of Hong Kong. She subsequently underwent ophthalmology training at a public hospital in Hong Kong. She joined the University of Hong Kong as Clinical Assistant Professor in 2013 to further her academic pursuit, where she can devote more time in researches. She has delivered more than 10 presentations in various regional and international conferences, including invited speeches, since she joined the University. Her research interest is in the field of Glaucoma.

Abstract:

Synopsis: The course will discuss how residents and general ophthalmologists can determine if there is progression of glaucoma, which is essential to aid further management. Assessments including slit lamp biomicroscopy, fundus photo, optical coherence tomography (retinal nerve fibre layer and ganglion cell complex; trend and event analysis) and visual field. Also, situations which make analysis difficult, such as in high myopia will be discussed. Objective: At the conclusion of the course, audience can get an overview of how they can use various techniques to assess glaucoma progression, the advantages and short-coming of each technique, and how they can integrate anatomical and functional assessment to help them derive a decision on when to step up the treatment.

Biography:

Jimmy S M Lai received his pre-fellowship training in the Princess Alexandra Eye Pavilion, Edinburgh and post-fellowship training in the Massachusetts Eye and Ear Infirmary, Boston, and the Aichi University, Nagoya, Japan. He is a pioneer in glaucoma research, in particular, the use of argon laser peripheral iridoplasty (ALPI) to the initial treatment of acute angle closure glaucoma and acute phacomorphic glaucoma and introducing the selective laser trabeculoplasty (SLT) and goniosynechialysis (GSL) to Hong Kong for the treatment of open angle and closed angle glaucoma. He is currently the Acting Head of the Department of Ophthalmology at the University of Hong Kong.

Abstract:

This instruction course will detail practical pearls of using the selective laser trabeculoplasty (SLT) in the treatment of all primary glaucoma subtypes: primary open angle glaucoma, primary angle closure glaucoma, and normal tension glaucoma. It will compass evidence-based information and instructor’s experiences on the following: the clinical indications for treatment, laser techniques (do’s and don’ts), potential complications and their management, post-laser medications and follow-up, repeated treatments, and the predictors of laser success and failure. The course will focus on using the SLT in Asian eyes, which are relevantly different to the Caucasian counterparts in terms of angle opening and pigmentations.

Biography:

Prof. Ayala Pollack is a Professor and Chairperson of the Ophthalmology Department at Kaplan Medical Center. She graduated from the Sackler School of Medicine, Tel Aviv University with the honour of distinction and award for excellent thesis. During Medical school she started basic science research in the Department of Embryology and Teratology, Sackler School of Medicine, Tel Aviv University, She completed training in Ophthalmology Kaplan Medical Center and in the Department of Ophthalmology, Rothschild Hospital, Haifa, Israel affiliated to the Technion-Israel Institute of Technology.

Abstract:

Background: The spectrum of foveal hypoplasia (FH) ranges from a narrow central avascular zone to that of absent foveal pit with continuity of the superficial vascular layers and absent FAZ. In cases of diabetic retinopathy in FH, these features results in a central micro-vascular disease with unique characteristics. Purpose: To present the pathological features of diabetic retinopathy in cases of FH as they are seen in retinal imaging. Methods: Patients with foveal hypoplasia and diabetic retinopathy underwent fundoscopic examination, OCT and FA imaging. The images were analyzed to determine the degree of hypoplasia and to identify the characteristics of the retinopathy. Results: The distribution of retinal capillaries reduced foveal avascular zone (FAZ) was demonstrated. Diabetic retinopathy in these cases was characterized by microaneurysms and hard exudates in extreme proximity to the foveola. Cystoid spaces within the retina were also more likely to occur at the center of the fovea. Conclusions: The natural history and implications for therapy of diabetic maculopathy are related to variations of foveal anatomy as well as to known systemic factors. In FH, micro-angiography presents centrally and early visual loss from edema and exudates may ensue.

Biography:

Ophthalmology Residency ( Universidad Nacional de Cuyo ) Chief Residency (Universidad Nacional de Cuyo) University teaching ( Universidad Nacional de Cuyo ) University Professor (Universidad del Aconcagua ) Member CAO ( Consejo Argentino Oftalmologia ) Member SAO (Sociedad Argentina Oftalmologia ) Member : ASCRS Pedkera PAAO KMSG ESCRS AAO Cornea Society Director Ophthalmology Residency Instituto Oftalmologico Guerrero Director International Courses : PRK – Complications ASCRS 1999 PKP Difficult and Challenging Cases ASCRS 2001 PKP Difficult and Challenging Cases ESCRS 2003 PKP Children (Co director ) AAO 2004 Amniotic Membrane ESCRS 2006 Fundamental Tools Ocular Surface PAAO 2007 Alteraciones Superficie Ocular Congreso Argentino Oftalmologia 2007 Cordinador KMSG PAAO 2011 Panelist KMSG PAAO 2015

Abstract:

In 2015 we are still performing PKP in patients with keratoglobe, regraft due to alterations in the interface in patients´previous PKPs. Also in cases of Hydrops or in alcali or acid severe burns or in Herpex Keratitis with severe alteration of all the corneal layers. In relation to cataract, with Phacoemulsification we have cases of : Phaco in previous Keratomileusis, Phaco in previous multiinsicional surgery with PKP due to diplopia or poliplopia. In other cases triple procedure was performed: Phaco + IOL + PKP . In some patients with residual astigmatism from post PKP, Phaco + toric IOL or IO phakic with clear cristaline. We have also unusual cases of spontaneous perforations of the cornea in which PKP was performed and then cataract surgery. All the above cases will be reported with iconography of each pathology, the surgical processes and the post op

Biography:

Professor Ningli Wang is the Director of Beijing Tongren Eye Center and the vice president of Beijing Tongren Hospital, which is one of the two largest eye centers in China and provides a comprehensive and seamless Ophthalmic Service for 30,0000 outpatients and 54,000 surgeries annually. He is also the Director of Beijing Institute of Ophthalmology and the president of School of Ophthalmology, Capital Medical University.

Abstract:

Canaloplasty for POAG with failed filtering surgery: Glaucoma is a leading cause of irreversible blindness. For many patients, surgical intervention is finally necessary to preserve the remaining vision. Glaucoma filtering surgery (GFS) is the main choice, which creates constant shunting of aqueous from anterior chamber into newly built subconjunctival space. Despite a great improvement, GFS has documented high complications and failure rate especially for primary open angle glaucoma (POAG) received repeated GFS, who runs higher risk of bleb insufficiency. Canaloplasty, a new non-filtering, bleb-free method, provides good IOP reduction with a favorable safety profile for POAG as initial procedure. We practiced 24 canaloplasty on POAG with failed GFS. For 18 patients with intact SC, a standard canaloplasty was done. Circumferential catheterization achieved in 89.2% eyes. In one year, IOP decreased by 34.1% (from 28.3±8.4 to 15.5±2.5 mm Hg), with topical medication reduced from 2.9±0.7 to 0.7±1.5. Surgery rate was 52.4% for complete success and 77.4% qualified criteria, both of which were similar as canaloplasty as an initial procedure. For patients with broken SC, we proposed modified canaloplasty, relying on our new technique of relay suture guided by illuminated trocar. Circumferential catheterization achieved in 83.3% eyes. At 9-months, IOP reduced to 17.7±4.5 mmHg and mean glaucoma medication use was 1.0±1.0 (baseline values were 32.5±5.2 for IOP and 3.2±0.4 for medication). For both groups, hyphema and clinically detectable bleb were the most common complications. According to our results, canaloplasty is a new, efficient and safe option for POAG with failed GFS.

Biography:

Dr. Sunalp's graduated from Oxford University Medical School at St. John’s College and continued his post-graduate medical education in ophthalmology at Stanford and the University of Southern California. His most recent educational accomplishment has been an MBA at the University of Tennessee. Throughout his career he has remained up to date on medical advancements by both participating and teaching continuing medical education courses. Dr. Sunalp has provided state of the art ophthalmologic services in the San Joaquin valley for the last 30 years. He has developed innovative techniques to treat common eye diseases in a safe and effective manner.

Abstract:

Purpose: We have devised a new method to mark the corneal axis of Toric IOL that is inexpensive and precise. Methods: In the office, a drop of ophthaine is placed on the eye, and the patient is asked to place his/her chin on the chin-rest of the Yag laser. The “Sunalp Yag laser lens’ is placed on the para limbal cornea with 90º lens corresponding to the 90º of the patient cornea. The Yag laser is focused at the mid cornea at 270º and a single laser pulse of 10 mjoules is aimed at 270º with 1-3 pulses in line, 0.5 mm apart. The laser pulse marks the cornea with a small disruption and blanching of the stroma that remains visible for 48 hours or longer. The Sunalp Yag laser lens is a 1 cm, 12 diopter single-use, acrylic lens, which will be available in the near furure. Results: Presurgical corneal marking using the Sunalp Yag laser lens, a lens specially designed for the Yag laser, allows for accurate alignment of toric IOL during surgical implantation. The markings remain clearly visible throughout the procedure and for an additional 48 hours, giving ample time for pre op marking. Conclusion: To avoid the pitfalls of preoperative unreliable marking with an ink pen, we have devised a method to mark the cornea using the Yag Laser. Using the Sunalp Yag laser lens, precise, durable makring can be made without the use of expensive equipment.

Biography:

Michael K Yoon is a full time Faculty Clinician and Scientist at Massachusetts Eye and Ear Infirmary/Schepens Eye Research Institute, teaching institutions of Harvard Medical School. His clinical expertise is in orbital diseases including tumors, thyroid eye disease and trauma. His research has focused on orbital anatomy and computer analysis of various structures. He has published over 55 peer-reviewed articles.

Abstract:

Metastatic scirrhous breast carcinoma to the orbit is a rare condition. It can cause a paradoxical decrease in the volume of the orbit causing secondary enophthalmos of the affected orbit. Other presenting signs include ptosis, superior sulcus deformity and diplopia. In some cases, the amount of tumor visible on CT or MRI can be much less than the actual degree of involvement. In order to better understand this rare and unusual condition, we performed a volumetric analysis of the various soft tissue components of the orbit using CT and MRI imaging. Imaging software associated with our hospital imaging interface (Synapse, FujiFilm, Tokyo, Japan) was utilized to outline the perimeter and calculate volume of the following structures on each slice of the image: orbit, globe, optic nerve, extraocular muscles, lacrimal gland, fat and visible tumor. Four cases of unilateral metastatic scirrhous breast carcinoma were identified. Imaging demonstrates the tumors as homogenous moderate density masses with indistinct borders. The mean volumes of the optic nerve, muscle and lacrimal glands were not statistically significant (p=0.36, 0.10, 0.15, respectively). The difference in orbital fat was nearly significant (10.43 normal vs. 9.00 diseased, p=0.06). Mean tumor volume was 0.29 cc. Although the tumor volume remains small, there can be a disproportionate degree of enophthalmos. In patients with a history of breast carcinoma who develop enophthalmos, even small areas of abnormality on imaging can denote more widespread tumor and should be biopsied.

Biography:

Ian Wong is currently Clinical Assistant Professor at the Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong (HKU). Since then, he has devoted his time and effort in academic research, and has to date published 42 international peer-reviewed journal articles. Other than that, he has written 7 book chapters, including one in the book RETINA 5e. He recently took up the role of Editor-in-Chief of the Hong Kong Journal of Ophthalmology.

Abstract:

PCV is characterized by recurrent subretinal pigment epithelial hemorrhages. Before indocyanine-green angiography (ICG) imaging was popular, PCV was sometimes misdiagnosed as neovascular age-related macular degeneration (AMD). With the advent of imaging modalities and deeper understandings of the disease, PCV is now recognized as a separate entity, with its own unique profile of clinical manifestations. Treatment strategy towards PCV has been revolutionized by recent clinical trials using combination therapy with ranibizumab and verteporfin. Currently, significant differences exist between treatment for PCV and neovascular AMD. There is a clear need in distinguishing PCV from neovascular AMD. Clinical photos, ICG findings, and optical coherence tomography scans will be used to illustrate real cases. Small quiz towards end of course will help audience fortify knowledge acquired. At the conclusion of this course, the audience will be able to distinguish a case of PCV, from a case of neovascular AMD. They will know how to formulate treatment strategies for a new case of PCV, and the most up-to-date evidences involved.

Biography:

Dr. Amy Lo obtained her Bachelor Degree (Distinction) in Chemistry from the University of Hawaii at Manoa and continued her education in the Johns Hopkins University School of Medicine, where she received her Doctoral degree from the Department of Neuroscience. She then joined the Institute of Molecular Biology in The University of Hong Kong as a Post-doctoral Fellow and later joined the Eye Institute (Department of Ophthalmology) as Assistant Professor. Her main research interest is neuroprotection in human diseases such as stroke and retinal diseases, focusing on the investigation of mechanisms controlling neuronal degeneration using experimental animal models and on the development of new molecular and cellular therapeutic approaches.

Abstract:

Retinopathy of prematurity (ROP) is a major ocular disorder of the pre-term neonates with unsatisfactory treatment. In ROP, uncontrolled neovascularization happens and may protrude into vitreous cavity, leading to lipid exudates and bleeding, which can impair vision severely. Both clinical and basic research supports the role of oxidative stress in ROP. Using a murine oxygen-induced retinopathy (OIR) model, the animal model for ROP, we showed that genetic deletion of aldose reductase (AR), the first enzyme in the polyol pathway that uses NAD(P)H as a cofactor for glucose metabolism, is beneficial in protecting the neonatal retina in OIR. AR-deficient retinae displayed smaller central retinal vaso-obliterated area, less neovascularization and reduced blood vessel leakage after OIR. The attenuated amplitudes and delayed implicit time of a-wave, b-wave and oscillatory potentials recorded in electroretinogram were recovered in these retinae. There were also less morphological change in horizontal, rod bipolar and amacrine cells. Taken together, AR deficiency reduced retinal vascular changes and preserved retinal neuronal function in the mouse model of OIR, suggesting a therapeutic potential of AR inhibition in ROP treatment with beneficial effects on both retinal vessels and neurons.

Biography:

Prof. Ayala Pollack is a Professor and Chairperson of the Ophthalmology Department at Kaplan Medical Center. She graduated from the Sackler School of Medicine, Tel Aviv University with the honour of distinction and award for excellent thesis. During Medical school she started basic science research in the Department of Embryology and Teratology, Sackler School of Medicine, Tel Aviv University, She completed training in Ophthalmology Kaplan Medical Center and in the Department of Ophthalmology, Rothschild Hospital, Haifa, Israel affiliated to the Technion-Israel Institute of Technology.

Abstract:

Purpose: To evaluate the course of wet AMD in eyes undergoing phacoemulsification and previously treated with anti-VEGF injections. Methods: Records of patients ≥50 years with AMD who underwent uneventful phacoemulsification and had completed a minimum of 6 months follow-up (F-U) after surgery were retrospectively reviewed. Patients with complicated surgery and incomplete data were excluded. Data recorded were best corrected visual acuity (VA), fundoscopy and OCT at beginning of F-U, prior to surgery, 1 month after surgery and at the end of F-U. Also recorded were number and timing of injections before and after surgery. Results: Included were 42 eyes of 38 patients with wet AMD receiving intravitreal anti-VEGF injections prior to surgery. VA improved significantly 1 month postoperatively, without a significant change in retinal thickness. Thirty two (76%) were “dry” and 10 (24%) were still “wet” just before surgery. Twenty six patients (62%) needed anti-VEGF injections during follow-up after surgery within average of 6 months. In eyes that were "dry" preoperatively the re-injection rate was lower than those that were still "wet" (56% vs. 80% respectively). The average time from surgery to the first injection was longer in preoperative "dry" than in "wet" eyes (7 and 3 months, respectively). Conclusions: In this study, cataract removal improves vision in wet AMD patients. In eyes that were stable within 6 months before surgery and their retina was dry preoperativly, the re-injection rate post surgery was lower and the time to first injection was longer as compared to those that were "wet" preoperatively. We suggest to consider drying the retina prior to surgery and to follow them closely postoperatively.

Biography:

Elie Beit-Yannai has completed his PhD at the Hebrew University Jerusalem, Israel. He leads research teams at the bio-tech industry and joined Ben-Gurion University in 2004. He has published more than 25 papers in reputed journals.

Abstract:

The trabecular meshwork TM is dynamic tissue responding to pressure stimuli and cellular signaling. TM increase in drainage resistance had been attributed to increase in intra ocular pressure, a major risk for glaucoma development. In previous study in our lab we were able to show that signaling between the non-pigmented ciliary epithelium (NPCE) and the TM exist, resulting in changes in protein expression and activity. We hypothesized that these intra drainage system tissue communications is carried, at least partially by exosomes. Exosomes are nanoparticles carrying a cargo of proteins, mRNAs and micro-RNAs which are believed to deliver signaling molecules that affect this outflow. Exosomes were extracted from NPCE cell line, characterized for size, Zeta potential, protein content and specific exosomes markers. Then, NPCE derived exosomes were incubated with human TM cell line and the exosomes fate was traced using confocal microscopy. Signaling pathway changes and their downstream effects were examined. We were able to show that NPCE derived exosome accumulate along time in the TM cells cytosol with specify. Within the TM cells the NPCE derived exosomes interfere with signaling pathway resulting in changes in key adhesion molecules.

Biography:

Wen-Chuan Wu has completed his Medical Degree from Kaohsiung Medical University and Ophthalmology Training at Kaohsiung Medical University Hospital. He is the Chairman of Taiwan Macular Society. He has published more than 50 papers in reputed journals.

Abstract:

Purpose: To analyze the long-term dynamic healing process of outer retinal changes for 1 year in patients who underwent a standard vitrectomy procedure for idiopathic macular hole (MH) repair. Design: Retrospective, consecutive, observational case series. Methods: Data were collected on 60 eyes of 56 patients (30 women, 26 men) that underwent successful pars plana vitrectomy (PPV) and internal limiting membrane (ILM) peeling for idiopathic MH from January 2011 to December 2012. The age distribution ranged from 56 to 85 years (mean: 64 years). Forty eyes underwent combined phacoemulsification, PPV, ILM peeling, and intraocular lens implantation; 20 preoperative pseudophakic eyes underwent PPV and ILM peeling only. The main outcome measures included logMAR best corrected visual acuity (BCVA) and macular microstructures determined by spectral-domain optical coherence tomography performed pre- and postoperatively during follow-up visits at 1, 3, 6, 9, and 12 months. Results: One month after surgery, 24 eyes (40%) showed normal external limiting membrane (ELM), 36 eyes (60%) showed normal ELM at 3 months and 54 eyes (90%) showed normal ELM 12 months after surgery. Six eyes (10%) revealed a continuous ellipsoid zone (EZ) at 1 month, 18 eyes (30%) at 3 months and 48 eyes (80%) at 12 months postoperatively. There were no eyes with a disrupted ELM in the presence of an intact EZ line. The eyes with intact ELM and or intact EZ line showed better BCVA than eyes with defects in ELM or EZ line. On the contrary, glial cell presentation is significantly associated with worse postoperative BCVA. However, the presence of foveal cystoid change is not significantly associated with postoperative BCVA. Conclusions: The ELM and EZ line at the fovea recovered and the presence of glial cells and cystoid space resolved gradually after surgery. The postoperative visual acuity was correlated with resolved glial cells and a restored ELM and EZ line.

Biography:

Ellen Koo, MD is an Assistant Professor at the Bascom Palmer Eye Institute, University of Miami Miller School of Medicine. She specializes in Cornea, Corneal Transplants and Cataract Surgery. She completed her Fellowship training in Cornea, Cataract Surgery and Refractive Surgery at the Wilmer Eye Institute, Johns Hopkins University School of Medicine. Prior to that, she completed her Ophthalmology residency at Brown University, Warren Alpert Medical School. She obtained her Medical Doctorate at the Eastern Virginia Medical School and her Bachelor’s of Arts Degree at the Johns Hopkins University. She serves as a reviewer for “The Journal of Ocular Immunology and Inflammation” and “The Journal of Clinical and Experimental Ophthalmology”.

Abstract:

Cataract surgery is considered a safe and highly successful procedure in the United States. The advent of femtosecond laser technology now provides newer and possibly safer options for the surgeon to successfully carry out cataract surgery. One of the possible advantages of the femtosecond laser, is that the laser technology creates a replicable and thus possibly a more structurally sound, clear corneal incision. As cataract surgery in this day and age is now expected, by patients, to be largely “suture-less,” the risks of endophthalmitis are now deemed to be higher as a direct correlation to the increase in popularity in clear corneal incisions. The clear corneal wound needs to be structurally sound, as a leaky clear corneal wound becomes a direct entry site for bacterial species. While the prospect of a safer, replicable surgery is appealing, it is important to also consider the possible disadvantages of the laser technology. The usage of femtosecond laser technology in creating the laser-assisted in-situ keratomileusis (LASIK), as opposed to the older method of the handheld micro-keratome, has been commonly used as an analogy. There has been a rise in Diffuse Lamellar Keratitis (DLK) with the increase in usage of the femtosecond laser in flap creation; though the exact causes of DLK remain unknown, it has been proposed that the laser induces “collateral” damage—cell death and inflammation of the corneal epithelium and thus possibly contributory to the rise of DLK cases. The anterior segment OCT could possibly lend us more insight into the possibility of “collateral” damage from the femtosecond laser when used in FLACS—thickness and structural changes of the different layers of the cornea, especially the epithelium, the stroma and the endothelium, could possible clue us into immediate collateral damage from the laser.

Biography:

Shao-Chun Chen completed his MD at the age of 25 years from Chang-Gung University. He specializes in Neuro-ophthalmology and Strabismus. He completed his Fellowship training at the Kitasato University and Hamamastu University. He is the Deputy executive secretary of Institutional Review Board and Specialist of Tissue Bank in the Taipei City Hospital. He has published more than 10 papers in international ophthalmological meetings.

Abstract:

The ischemic optic neuropathy (ION) is one of the most common acute optic neuropathy in the aged population. We usually categorized ION into nonarteritic or arteritic. The vasculitis is the leading cause of arteritic one, where compartment syndrome in optic-nerve hand is the pathophysiology of the nonarteritic one. There are many specific symptoms and signs can help us to classify which type of ION belongs. Dialysis is associated with many kinds of ocular problems. These include chronic conjunctival inflammation, metastatic corneal calcification, bullous retina detachment, and ION. Here we review the reported patients who had dialysis-induced ION. We analysis the age, gender, onset, laterality, visual outcome, visual field change, and fluorescein angiography. We find this group of ION presentation does not belong to arteritic ION or nonarteritic ION. We suspect this particular type of ION belongs to the venous stasis induced optic-disc hypoperfusion.

Biography:

Dr. Shum is an assistant professor in Mechanical Engineering at the University of Hong Kong. He received his undergraduate degree from Princeton University, and Ph.D. i from Harvard University. His research interests include emulsions, microfluidics, emulsion-templated materials and soft matter. He received the Early Career Award by the Research Grants Council of Hong Kong. He is an editorial board member in “Scientific Reports” published by the Nature Publishing Group and in other journals. He has published ~70 articles and is a reviewer for journals, including “Nature Nanotechnology” and “PNAS”, and for funding agencies in the United States, Europe and Asia.

Abstract:

Diffusion of protein-based drugs (e.g. ranibizumab and bevacizumab) in the eye often depends on the viscosity and the mesh size of the vitreous humor. The diffusion speed of molecules within a liquid is inversely proportional to the viscosity, and therefore the molecules diffuse much slower in vitreous humor than in water. The mesh size of the vitreous affects the diffusion of drugs with a large molecular weight due to the role of the network as a physical barrier to the drugs involved. However, little has been studied regarding the interaction (or the binding) between the vitreous components and the drug molecules. The surface charge on the vitreous component that causes the binding with the drug molecules also potentially plays a significant role in the diffusion of the drug molecules. This effect may become very significant particularly in the diffusion of small molecular drugs (e.g. dexamethasone). In this study, the interaction between the small drug molecules and the vitreous components is studied. The interaction being studied is independent of the viscosity (by using homogenized vitreous samples) and the mesh size of the vitreous (small testing molecules). Our results show that the diffusion of the small aqueous soluble molecules is highly interfered by the macromolecules present in the vitreous content when compared with water as the diffusion medium. Our results further suggest that the small molecules probably bind with the collagen, but not the hyaluronate, that are present in the vitreous humor.

Biography:

Shao-Chun Chen completed his MD at the age of 25 years from Chang-Gung University. He specializes in Neuro-ophthalmology and Strabismus. He completed his Fellowship training at the Kitasato University and Hamamastu University. He is the Deputy executive secretary of Institutional Review Board and Specialist of Tissue Bank in the Taipei City Hospital. He has published more than 10 papers in international ophthalmological meetings.

Abstract:

The ischemic optic neuropathy (ION) is one of the most common acute optic neuropathy in the aged population. We usually categorized ION into nonarteritic or arteritic. The vasculitis is the leading cause of arteritic one, where compartment syndrome in optic-nerve hand is the pathophysiology of the nonarteritic one. There are many specific symptoms and signs can help us to classify which type of ION belongs. Dialysis is associated with many kinds of ocular problems. These include chronic conjunctival inflammation, metastatic corneal calcification, bullous retina detachment, and ION. Here we review the reported patients who had dialysis-induced ION. We analysis the age, gender, onset, laterality, visual outcome, visual field change, and fluorescein angiography. We find this group of ION presentation does not belong to arteritic ION or nonarteritic ION. We suspect this particular type of ION belongs to the venous stasis induced optic-disc hypoperfusion.

Biography:

Yong Cheng has completed his MD from Peking University. He specializes in vitreo-retinal disorders that require either medical or surgical treatment. He has taken part in lots of multicenter research and published more than 10 papers in reputed journals.

Abstract:

Objectives: To compare the outcomes of Conbercept therapy between two different angiographic subtypes of Polypoidal Choroidal Vasculopathy (PCV) Methods: Fifty-eight patients of PCV were classified into two phenotypes according to indocyanine green angiography (ICGA). In type-1, both feeder and draining vessels are visible on ICGA and network vessels are numerous. In type-2, neither feeder nor draining vessels are detectable and the number of network vessels is small. The patients were treated with intravitreal Conbercept (IVC) for 3 months. Additional IVC was given at subsequent monthly visits, if needed. The patients were followed-up for 12 months and changes in mean BCVA, central retinal thickness (CRT), serous retinal detachment (SRD), hemorrhage and number of Polypoidal lesions were evaluated. Results: The mean BCVA in type-2 PCV (15.92±9.7614.10±9.07) achieved a significantly greater improvement in than the type-1 (14.10±9.07) at month 12 (p<0.01). And the mean CRT decrease was numerically greater in type-2 (120.44±73.81) compared with type-1 (106.48±72.33) at month 6 (p<0.01) and greater in type-2 (130.21±76.28) compared with type-1 (111.67±79.57) at month 9 (p<0.01). There was no significant difference between the two groups for the decrease in SRF thickness, PED height and regression of polyps from month 3 to 12 (p>0.05). Conclusions: Classification systems for PCV will show differences in presentation, natural history or response to anti-VEGF treatment and might therefore provide a new key to the choice of treatment of the disease.

Biography:

Peirong Lu received his Ph.D. degree from Kanazawa University at 2004. He did his postdoctoral training at Soochow University. Currently, he is the professor and director of Department of Ophthalmology, the First Affiliated Hospital of Soochow University. His research focuses on ocular neovascularization and cataract and is well funded. He has published more than 20 papers including Invest Ophthalmol & Vis Sci, Journal of Immunology, Cornea, Molecular Vision, and American Journal of Pathology.

Abstract:

White cataract occupies certain proportion in cataract patients in developing country. Most of the white cataracts have to give up the refractive IOL implantation because of the limited accuracy of the axis length and IOL power measurement. However, the white cataract patients also have the right to choice refractive IOL and obtain satisfied uncorrected distance and near visual acuity and spectacle independence after cataract surgery if we can detect the axis length precisely. To evaluate the outcomes of secondary multifocal intraocular lens (IOL) implantation in white cataract eyes, white cataract patients accepted secondary multifocal IOL implantation between June 2014 and January 2015 were retrospective reviewed. Ocular biometric parameters, surgical and visual outcomes were analyzed. Compared to conventional primary IOLs implantation, for the optimal white cataract patient, the white cataract were firstly extracted, following the optical biometry being precisely measured and also it is easy to identify whether the patient has adequate visual function, then the multifocal intraocular lens was secondary implanted. A total of five appropriate white cataract patients were enrolled in the secondary multifocal IOL implantation and were retrospective reviewed. The novel management strategy of secondary multifocal IOLs implantation were successful and without obvious adverse events. All the patients were achieved satisfied near and distance visual acuity and spectacle freedom. The outcomes suggest our novel management strategy is a safe and effective option for white cataract undergoing cataract surgery.

Biography:

Li-Ju Lai had completed her PhD from Chang Gung University in Taiwan and postdoctoral studies from Univeristy of Pittsburgh in USA. She is the director of Health Promotion for Children Program in Chang Gung Memorial Hospital, Chia-Yi branch, Taiwan. She has published more than 26 papers in reputed journals and has been serving as an editorial board member of repute.

Abstract:

Pediatric optic neuritis characteristically presents with significant visual loss, which is easily mis-diagnosed with malingering especially in under-served medical area of Taiwan. Recurrent optic neuritis episodes could be a red flag sign of underlined multiple sclerosis and could result in other severe complications . This is a cross-sectional community-based study, 3918 children participated in the program of Health Promotion for Children in Chia-Yi with their informed content during the year of 2015. Six children were diagnosed with pediatric optic neuritis. Careful medical history and drug history were evaluated. Visual acuity, intraocular pressure (IOP), color test, optical coherence tomography (OCT), visual evoke potential (VEP), and magnetic resonance imaging (MRI) were used for diagnosis. Autoimmune survey with serum level of Complement 3 (C3), complement C4 (C4), anti-nuclear antibody (ANA), Anti-ENA, Anti-neutrophil cytoplasmic antibody (ANCA), and Anti-Aquaporin 4 (AQP4) antibody were also done. The incidence of pediatric optic neuritis is different from the data of western countries. The relationship between the influenza vaccine and optic neuritis in children needs further evaluations. Children who claim vision loss or headache with unknown causes should receive further management and treatment. Careful history taking is as important as the color test, visual acuity and visual evoked potential examination to diagnose the optic neuritis and prevent further complications.

Biography:

Dr. Chang received his MD from University of Missouri, Kansas City School of Medicine. He completed his residency at the prestigious Washington University in St. Louis, followed by a research and clinical glaucoma fellowship at the renowned Bascom Palmer Eye Institute in Miami. He has published over 33 peer-reviewed papers, delivered 85 invited national and international lectures, and been awarded 11 grants. He has a full-time clinical practice, teaches, volunteers internationally, and is a Stanford Biodesign Faculty Fellow. He is a consultant for multiple ophthalmic companies as well as a scientific advisor to early stage medical device startups.

Abstract:

This oral presentation will cover tips and pearls on incorporating the Glaukos Istent, a minimally invasive glaucoma surgery (MIGS), into your ophthalmology practice for the treatment of open angle glaucoma. It will encompass an overview of trabecular meshwork-based ab interno surgery, discuss the new devices with a focus on Istent, introduce gonioscopic angle surgery as a new skill, provide surgical videos of optimal and suboptimal Istent placement, discuss patient selection, technique, efficacy, post-op management, and complications, and finally, review the literature on Istent outcomes. The course is presented from a United States perspective, and briefly mentions cataract surgery in conjunction with the Istent.

Biography:

Dimitris Hatziavramidis has completed his BSc at NTUA (Greece) and MSc at University of Manchester (UK) and his PhD at University of Illinois (USA). He has spent most part of his career working for academic institutions and large corporations in the USA and is currently a Professor at NTUA. Prior to this, he served as a Professor and Director of the Particle Technology and Crystallization Center for pharmaceutical products, in the Department of Biological and Chemical Engineering at Illinois Institute of Technology in Chicago, IL. He is a Fellow of AIChE. He has published extensively in reputed journals and has several patents.

Abstract:

Age-related macular degeneration (AMD) is a progressive, neurodegenerative, occular disease and a leading cause of irreversible loss of vision in aging adults in developed countries. Its pathogenesis is characterized by uncontrolled proliferation of cells and cell growth in blood vessels, leaking of blood and proteins and aberrant folding, aggregation and accumulation of proteins. Over-expression of the vascular epithelial growth factor (VEGF) causes uncontrolled blood vessel growth resulting in violation of the blood-retina barrier and accumulation of blood and protein debris causes neuro-degeneration of cells in the retinal pigment epithelium (RPE) and tissue dysfunction. The current treatment of AMD is primarily based on anti-VEGF drugs which are administered by intra-vitreal injection. It has been recently proposed to administer exogenous heat shock proteins such as Hsp70 by intra-vitreal injection in order to clear accumulated debris from RPE and inhibit aggregate-based cell neuro-degeneration. An equally effective and less vision-threatening than intra-vitreal injection route of administration of the above macromolecular drugs is trans-scleral delivery from an implant in the posterior eye, made out of a poly (N-isopropyl acrylamide) (NIPAM) thermally sensitive gel. This gel undergoes a phase transition characterized by a lower critical solution temperature (LCST) of 33oC, below which the drug is loaded in the gel and above which the drug is released from the gel.

Biography:

Ms Lalchan pursued her postgraduate degree in ophthalmology and is fellowship trained in glaucoma. She has worked at Leeds Teaching Hospitals, Moorfield’s Eye Hospitals and The Western Eye Hospital in London. She is a member of the International Society for glaucoma Surgery and was awarded The International Ophthalmology in Education Award by AAO in 2015. She is a scientific advisor for the Diabetes Association of Trinidad and Tobago. Additionally, she is the founder and President of the non-profit GiFT (Glaucoma iFoundation of Trinidad and Tobago and director of Lily-The Eye Specialist Ltd and The Glaucoma Specialist Centre.

Abstract:

AIM: To qualify the epidemiology of patients diagnosed with primary open angle glaucoma; to analyse education pathway and, to determine, within the practical clinical setting, the efficacy of first line treatment within a high risk population . METHOD: A retrospective, consecutive series was analysed. The patient pathway incorporated multiple educational components ie educational videos, booklets, perimetry questionnaire, drop instillation techniques, compliance tips, prognosis and risks to family members. Inclusion criteria: age >35yrs, open angle glaucoma, new diagnosis and treatment initiation (glaucomatous optic neuropathy and/or visual field defect consistent with retinal nerve fibre layer damage), refractive error +3.0 to -5.0DS. RESULTS: Demographics: N 131 eyes ; mean age 60yrs (36-80yrs, SD 8.92); 28% had family history of glaucoma. The pre-treatment IOP mean 24.5mmHg (12-62mmHg SD 8.59;); mean CCT 537um ( 483-619um SD 26.4;); 78.5% of eyes had a CCT <555um. 8.4% had a mean deviation of <-12 db. There was no statistically significant difference ,one way ANOVA p 0.06. CONCLUSION: Education needs to be emphasized within the patient pathway in developing countries. First line therapy demonstrates good efficacy in a practical clinical scenario in a high risk population.

Biography:

Prof. Ayala Pollack is a Professor and Chairperson of the Ophthalmology Department at Kaplan Medical Center. She graduated from the Sackler School of Medicine, Tel Aviv University with the honour of distinction and award for excellent thesis. During Medical school she started basic science research in the Department of Embryology and Teratology, Sackler School of Medicine, Tel Aviv University, She completed training in Ophthalmology Kaplan Medical Center and in the Department of Ophthalmology, Rothschild Hospital, Haifa, Israel affiliated to the Technion-Israel Institute of Technology.

Abstract:

In the era of OCT, we are often asked to make a diagnosis relying on an OCT appearance. The following cases represent two extreme varieties of unusual foveal conditions. The first is foveal hypoplasia which may be isolated or associated with other ocular conditions and characterized by the continuity of the inner retinal layers in the fovea with variable degrees of decreased foveal pit and absence of cone specialization. Decreased visual acuity and nystagmus may be present, dependent on the degree of hypoplasia. The improved resolution of OCT helps to diagnose and differentiate the degree of foveal hypoplasia. The second condition is a “double fovea” configuration on OCT which was first suspected to be an evolutionary remnant of ancient foveal configuration presently found in birds. A careful clinical examination and using a different scanning plane helped to discover the reason of this unusual appearance on OCT. Both examples show that OCT is a very important tool for diagnosing and characterizing different foveal conditions but is an adjunct to a careful clinical examination and that its interpretation is meaningful only in that context.

Biography:

Dr. Shum is an assistant professor in Mechanical Engineering at the University of Hong Kong. He received his undergraduate degree from Princeton University, and Ph.D. i from Harvard University. His research interests include emulsions, microfluidics, emulsion-templated materials and soft matter. He received the Early Career Award by the Research Grants Council of Hong Kong. He is an editorial board member in “Scientific Reports” published by the Nature Publishing Group and in other journals. He has published ~70 articles and is a reviewer for journals, including “Nature Nanotechnology” and “PNAS”, and for funding agencies in the United States, Europe and Asia.

Abstract:

Diffusion of protein-based drugs (e.g. ranibizumab and bevacizumab) in the eye often depends on the viscosity and the mesh size of the vitreous humor. The diffusion speed of molecules within a liquid is inversely proportional to the viscosity, and therefore the molecules diffuse much slower in vitreous humor than in water. The mesh size of the vitreous affects the diffusion of drugs with a large molecular weight due to the role of the network as a physical barrier to the drugs involved. However, little has been studied regarding the interaction (or the binding) between the vitreous components and the drug molecules. The surface charge on the vitreous component that causes the binding with the drug molecules also potentially plays a significant role in the diffusion of the drug molecules. This effect may become very significant particularly in the diffusion of small molecular drugs (e.g. dexamethasone). In this study, the interaction between the small drug molecules and the vitreous components is studied. The interaction being studied is independent of the viscosity (by using homogenized vitreous samples) and the mesh size of the vitreous (small testing molecules). Our results show that the diffusion of the small aqueous soluble molecules is highly interfered by the macromolecules present in the vitreous content when compared with water as the diffusion medium. Our results further suggest that the small molecules probably bind with the collagen, but not the hyaluronate, that are present in the vitreous humor.

Biography:

Hae Min Kang earned her MD at the age of 25 from Yonsei University College of Medicine where she also pursued postdoctoral studies. After completion of retinal fellowships, she is now an associate professor at Catholic Kwandong University College of Medicine with position of the head of Retinal department in International St.Mary’s Hospital. She has published more than 20 papers in reputed SCI journals, and she has been serving as an editorial board member and the expert reviewer board of repute. Her research interest lies on age-related macular degeneration, especially on polypoidal choroidal vasculopathy.

Abstract:

Polypoidal choroidal vasculopathy (PCV) is characterized by abnormal branching vascular networks with terminating polypoidal lesions. PCV is known to be prevalent amongst Asian population, accounting up to 50% of presumed exudative age-related macular degeneration (AMD). PCV is now generally considered to be a peculiar subset of exudative AMD, however, recent studies also suggest that PCV is one of pachychoroid diseases. Currently, the mainstay of treatment for PCV includes anti-vascular endothelial growth factor (VEGF) therapy, photodynamic therapy (PDT), or combination therapy (PDT combined with anti-VEGF therapy). PDT is still effective treatment option for PCV, whereas it is not considered as the primary treatment for typical exudative AMD. When we start treatment for PCV, several points should be concerned because of its distinct features. Although the natural course of PCV seems to be more favorable than that of typical exudative AMD, PCV frequently recurs despite of treatments, leading to visual deterioration. Thus, thorough long-term follow-up is necessary for the patients with PCV. In addition, hemorrhagic tendency of PCV also should be taken into account, especially when considering PDT for PCV. PCV can lead to profound subretinal hemorrhage or break-through vitreous hemorrhage which may cause sudden visual loss.

Biography:

Wencan Wu has completed his PhD at the age of 33 years from Xiangya Medical College of Central Southern University and from Oct 2013 to June 2015 he studied as a clinical ＆ research fellow at Bascom Palmer Eye Institute of University of Miami. He is specialized the endoscopic techniques in the ophthalmology. Now he is the director of the Center of Orbital ＆ Oculoplastic Surgery in the Eye Hospital of Wenzhou Medical University. He has published more than 22 papers in reputed journals and has been serving as an editorial board member of many journals.

Abstract:

BACKGROUND: Visual loss is a dreaded outcome of patients with fibrous dysplasia due to compressive optic neuropathy resulted from excessively abnormal growth of the sphenoidal bone. Even though there are many controversies, to remove the hypertropic bone to release the compression on the optic nerve is the base for vision recovery. Till now many methods have been applied to unroof the nerve therapeutically to recover the visual acuity in the setting of optic nerve dysfunction, however, the reported outcomes are mixed. Here we introduced a novel mini-invasive surgical approach to decompress the optic nerve which was guided by navigation surgical system and its results were reported. METHODS: From 2014.1 to 2015.12, patients who were diagnosed compressive optic neuropathy just resulted from fibrous dysplasia were performed the surgery of endoscopic transnasal optic nerve decompression guided by a magnetic navigation surgical system. Before operation, pupil examination, vision function examinations included Snellen’s visual acuity, 30ºvisual field and pattern VEP, the orbital high-resolution CT scan were conventionally performed. Patients’ age, demographics and the surgical procedures, follow-up time, results of the surgery and complications were recorded. RESULTS: Totally, 8 patients received the surgical treatment of endoscopic transnasal optic nerve decompression. All patients were determined compressive optic neuropathy according to the history and various clinical examinations. All surgeries were uneventfully completed. The patient age ranged from 8 years to 16 years, with male 3 and female 5. The history of obvious visual disorders ranged from 11 months to 3 years. Six patients had bilateral compressive optic neuropathy, and while, only one side was performed the surgery and the other as the control. All patients were followed up for 9 months to 15 months, with an average of 12.1±2.5 months. The surgical time ranged from 2.5 hours to 6.5 hours, with an average of 3.4 ±1.2 hours. The visual acuity ranged from light perception (LP) to 0.4. After surgery, the visual acuity improved significantly in all 8 patients and no changes in the controlled sides. No complications, including visual decent, infection, CSF leakage, and nose disorders, happened. CONCLUSIONS: The therapeutic surgery of endoscopic transnasal optic nerve decompression guided by navigation surgical system would be an advocated treatment of visual recovery for patients with continuous deterioration of vision resulted from fibrous dysplasia, with advantages of reliable outcomes of visual recovery, minimal morbidity, safety, and few complications.

Biography:

Dr. Kin CHIU completed her Master and Bachelor of Clinical Medicine degree in Tianjin Medical University, P.R. China. She focused on neuroscience research and got her Ph.D in the University of Hong Kong. Her long term research goal is to find a way to prevent continous visual loss in neurodegenerative retinal diseases, such as glaucoma and age-related macular degeneration. Her research works focus on investigating the mechanism of neuronal degeneration and finding new approaches to prevent neuronal death and promote neuronal survival and regeneration. Related treatment strategies include immune modulation, electrical stimulation and optogenetic therapies.

Abstract:

Papaverine is an opium alkaloid antispasmodic drug, used primarily in the treatment of visceral spasm and vasospasm. It is also known as a specific inhibitor of phosphodiesterase (PDE) 10A. In striatonigral and striatopallidal neurons, inhibition of PDE 10A by papaverine activated cAMP/PKA signal cascade. This study was aimed to investigate the effects of papaverine on the survival of retinal ganglion cells in rat optic nerve transection model. After intraorbital optic nerve (ON) crush of the right eye, 2 l of BSS or 50, 200, 500 g/ml papaverine was injected to vitreous cavity in the injured eye. At 2 or 7 days after the insult, retina samples were collected for retinal ganglion cell (RGC) count and immunohistochemistry analysis. At seven days, comparing to the BSS control group, RGC density of the 500 g/ml group showed significant increased survival of RGC. Immunoreactivity of phosphorylated-cAMP response element binding protein (p-CREB) was not detectable in the BSS control group. Increased expression of p-CREB was detected in the RGC layer and inner neuclear layer of the papavarine treated groups at both 2 and 7 days groups. Our result showed that papaverine was neuroprotective to RGC when their axons were transected in the crush model. This effect might be through up-regulation of the p-CREB.

Biography:

Bonnie Nga Kwan Choy graduated from the Faculty of Medicine, the University of Hong Kong. She subsequently underwent ophthalmology training at a public hospital in Hong Kong. She joined the University of Hong Kong as Clinical Assistant Professor in 2013 to further her academic pursuit, where she can devote more time in researches. She has delivered more than 10 presentations in various regional and international conferences, including invited speeches, since she joined the University. Her research interest is in the field of Glaucoma.

Abstract:

Glaucoma is a common chronic eye disease that can result in blindness. Apart from intraocular pressure control with medications, laser and surgery, glaucoma patients often ask about how they can achieve better glaucoma control in their daily life, whether any diets or habits they should adopt or avoid. There are literatures showing that calories restriction, low salt diet and green tea (anti-oxidant) intake, and use of food supplements such as wolfberry may help with glaucoma control, while coffee should be avoided as it may cause intraocular pressure elevation. Smoking which induces vasoconstriction also adversely affect glaucoma control. Even during sleep, head posture is shown to affect intraocular pressure, and glaucoma tends to be more severe on the side which patients lay. Physical exercise was found to lower intraocular pressure, so regular exercise should be advised for glaucoma subjects. Apart from controlling intraocular pressure, management of systemic diseases including hypertension, diabetes, obstructive sleep apnea is essential to achieve optimal glaucoma control. The talk will include literature review of how the above life styles may contribute to glaucoma management. Ophthalmologists can then offer suggestions to how patients may help managing the diseases in their daily life, in addition to ensuring compliance to glaucoma medications.

Biography:

Ian Wong is currently Clinical Assistant Professor at the Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong (HKU). Since then, he has devoted his time and effort in academic research, and has to date published 42 international peer-reviewed journal articles. Other than that, he has written 7 book chapters, including one in the book RETINA 5e. He recently took up the role of Editor-in-Chief of the Hong Kong Journal of Ophthalmology.

Abstract:

Viral retinitis is a group of conditions including Cytomegalovirus (CMV) retinitis, Progressive Outer Retinal Necrosis (PORN), and Acute Retinal Necrosis. Despite different aetiologies, there are similarties. Traditionally, CMV retinitis affected Human Immunodeficiency Virus (HIV) infected patients, but is now being increasingly recognised outside of this group. Highly Active Antiretroviral Therapy (HAART) has changed the presentation of CMV retinitis, whilst the advent of intravitreal antivirals has changed the treatment options available. This course aims to highlight these and other trends in viral retinitis via the below talks: 1. Who is at risk? Background & demographics. 2. Situation in Asia vs Western patients. 3. Presenting signs and symptoms 4. Diagnostic challenge - how to make a diagnosis? 5. Therapeutic challenge - Medical treatment & long term prophylaxis 6. Therapeutic challenge - Surgical treatment 7. Summary + case study + small quiz

Biography:

Dr. Gyanendra Lamichhane worked as Ophthalmologist (Phaco surgeon and medical retina specialist) at Shree Rana Ambika Shah Eye Hospital, Lumbini Eye Institute, Bhairahawa, Nepal from 15th June 2009 -19th February 2013. This institute is affiliated with the National Academy of Medical Sciences (NAMS), Nepal. Experience of more than twenty thousands (30,000) cataract and other ocular surgeries. House Officer, Universal College of Medical Sciences Bhairahawa, Nepal (2004-2006).

Abstract:

Aim : To study spectral domain optical coherence tomography (SD-OCT) characteristics of retinal layers in branch retinal vein occlusion .Methods :30 patients with branch retinal vein occlusion attending vitro retina clinic in a tertiary eye hospital were studied with SD-OCT . Integrity of inner segment outer segment junction, External limiting membrane, central retinal thickness and presence or absence of serous macular detachment were analyzed .Results :24 (80%) patients had disrupted photoreceptor Inner Segment Outer Segment(IS/OS) integrity. External Limiting Membrane was disrupted in 66.66% patients ( n=20). Cystoid Macular Edema was present in 53.33% patients (n=16). Average central retinal thickness was 432.9 μm. Conclusions: Spectral domain OCT characteristics can help to detect the changes in various retina layers and thus predict the visual outcome in patients with macular edema due to branch retinal vein occlusion. Keyword: SD-OCT, IS/OS junction, Branch retinal vein occlusion

Biography:

Jasleen Kaur Jolly is an optometrist working for the Nuffield Laboratory of Ophthalmology, University of Oxford and Oxford Eye Hospital. She studied at Cardiff University and the University of Manchester, working across the world in various settings to gain a wide range of experience. She is actively involved in clinical research in the fields of retinal gene therapy, cataract surgery outcomes and low vision. Her main interest is improving outcome measures following gene therapy treatments.

Abstract:

Purpose: We set out to characterize the pattern of fundus auto-fluorescence (AF) loss in choroideremia (CHM) patients of varying ages and disease severity in order to determine the average rate of progression of this potential disease biomarker. Methods: Fifty consecutive CHM patients (100 eyes) attending outpatient clinics at Oxford Eye Hospital underwent analysis with the Heidelberg OCT Spectralis with auto-fluorescence capabilities. The area of residual AF was traced using Heidelberg Eye Explorer. Bland-Altman analysis was used to calculate the coefficient of repeatability (CR). The degree of AF loss was correlated to age and the pattern of residual AF constructed into color-coded maps in order to gain insight into the mechanism of disease progression. Results: The CR for measurement of AF area is <1% indicating a small change is likely to be significant. Correlation of patient age and area of residual AF produced a clinically relevant index of expected anatomical disease. Progression is 5-10% of the residual area each year and follows a logarithmic pattern with age (r=0.69, P<0.001). The mean half-life of AF is 9 years. Qualitatively, the pattern of remaining AF was bifocal, with maximal preservation around the fovea (predominantly temporal) with late preservation around the optic disc. Conclusions: The area of residual AF in CHM can be measured reproducibly and shows a distinct pattern of loss. The residual area is inversely correlated to age. The ratio of the two variables may provide useful information regarding the rate of progression for any individual at a point in time.

Biography:

Abdulelah A. Al-Abdullah has completed his Vitreoretinal and Uveitis fellowship 2014 at King Khaled Eye Specialist Hospital, He is currently vitreoretinal and uveitis consultant at King Khaled Eye Specialist Hospital.

Abstract:

PURPOSE: To compare the incidence and characteristics of retinal complications following implantation of two types of phakic intraocular lenses (PIOLs) in patients with myopia. METHODS: In this comparative, retrospective study, 603 eyes of 344 patients with myopia underwent implantation of either an Artisan iris-fixated phakic intraocular lens IOL (Artisan; Ophtec, Groningen, Netherlands) (Artisan group) or a Visian implantable collamer lens (ICL; STAAR Surgical Company, Monrovia, CA) (ICL group) between June 2005 and December 2013. Preoperative, operative, and postoperative clinical data were collected on the incidence of retinal complications, including rhegmatogenous retinal detachment (RRD) or choroidal neovascular membrane (CNVM). RESULTS: The Artisan lens was implanted in 185 (30.68%) eyes and 418 (69.32%) eyes underwent ICL implantation. Mean follow-up was 26.78 months (range: 9 days to 98 months). Mean preoperative spherical equivalent (SE) was -12.44 ± 4.43 D (range: -1.13 to -31.00 D). The overall rate of retinal complications was 1%. Postoperatively, 3 (0.7%) eyes developed RRD in the ICL group, and no eyes developed RRD in the Artisan group. Submacular hemorrhage was observed in 1 (0.24%) eye in the ICL group. Two (1%) eyes developed CNVM in the Artisan group. The mean time from PIOL implantation to retinal complications was 15.6 months (range: 0.03 to 43 months). CONCLUSIONS: Implantation of ICL or Artisan phakic IOL demonstrated comparable rates of retinal complications. Anterior chamber PIOL does not increase the risk of retinal detachment or CNVM in patients with myopia.

Biography:

Jennifer Joy Y Santos-Rayos completed her Medicine degree in 2011 and Ophthalmology training in 2014 from the University of the Philippines – Manila, Philippine General Hospital. She is presently working with the Philippine Eye Research Institute as Project Manager and researcher, working for research projects commissioned by UNICEF, Department of Health and the Philippine Health Insurance Corporation. She also has a private practice in Manila. Her study entitled “Macular Pigment Optical Density among Filipinos with Age-related Macular Degeneration after Lutein and Zeaxanthin Supplementation” has won in several research competitions from the Philippine Ophthalmology Association and Philippine College of Surgeons.

Abstract:

Objectives: This study determined the baseline Macular Pigment Optical Density (MPOD) for those without retinal disease (group 1), those with non-exudative Age-related Macular Degeneration (AMD) (group 2), and those with exudative AMD (group 3). The effect of Lutein-Zeaxanthin supplementation was also determined. Method: For this study, 120 participants completed the baseline MPOD measurement and supplementation of Lutein (12 mg/day) and Zeaxanthin (1 mg/day) for 90 days. Factors of MPOD were also obtained through a questionnaire. Results: The mean baseline MPOD for the three groups were as follows: 0.382 DU (+ 0.10) for group 1, 0.333 DU (+0.07) for group 2, and 0.283 DU (+0.07) for group 3. Baseline MPOD of group 1 was statistically higher than baseline MPOD of group 2 (p=0.021) and group 3 (p=0.001). Mean baseline MPOD of group 2 is significantly higher than group 3 (p=0.017). MPOD after supplementation was also statistically significant using one-way repeated measures ANOVA. For Group 1, the MPOD levels increased significantly every month of supplementation, except on the third month when it did not reach statistical significance (p=0.001, p=0.003 and p=1.00 respectively). For Groups 2 and 3, MPOD levels increased significantly every month (group 2 p=0.021, p=0.010, p=0.008; and group 3 p=0.000, p=0.026, and p=0.00). Of the factors tested, weak and non-significant correlation was found. Conclusion: Patients without retinal disease have higher MPOD than patients with Non-neovascular AMD, and an even higher MPOD than patients with neovascular AMD. Supplementation increased the MPOD for three months.

Biography:

Michael Banitt is an Associate Professor of Ophthalmology at the University of Washington and practices clinical ophthalmology in the area of Cornea and external diseases. He has published over 35 articles in peer reviewed journals.

Abstract:

We describe and demonstrate a novel device for insertion of donor tissue during Descemet’s Membrane Endothelial Keratoplasty (DMEK). The device is a double cylinder with air outlet openings on the inner cylinder. Human corneas not suitable for transplantation were prepared using standard “SCUBA” technique for Descemet’s Membrane Endothelial Keratoplasty. While still submerged and the tissue is completely free from the donor stroma, it is gently placed over the inner cylinder of the device and allowed to wrap around it. The device with the donor endothelium is lifted into the air and allowed to coil around the central cylinder completely with the endothelium side out. The protective outer cylinder is slid with respect to the inner cylinder and donor endothelium to cover and protect it while inserting it through the corneal incision. The device has markings to maintain sidedness and location of the tissue. When inside the anterior chamber the outer cylinder is retracted and air is injected through the inner cylinder and through holes which unfolds the graft towards the iris, so the endothelium orients posteriorly. The device is removed from the eye. The last step is commonly performed with DMEK surgery where air is removed from between the graft and the host cornea and then reinjected under the tissue specifically between the iris and the graft. In conclusion, we demonstrate a novel device capable of inserting DMEK donor tissue into an eye atraumatically, maintain the orientation and unfold the tissue, simplifying the major challenging steps of DMEK surgery.

Biography:

Lamberto A. Ilagan Jr MD is an Ophthalmologist from the Philippines. He has completed his Medical Education at the University of Santo Tomas Faculty of Medicine and Surgery. He had his residency training in Ophthalmology at the University of Santo Tomas Hospital. He received his Diplomate Status in Ophthalmology from the Philippine Board of Ophthalmology in 2009. He is a member of the Philippine Academy of Ophthalmology. Currently he is the Head of Division of Ophthalmology in Healthway Medical Greenbelt 5 and is the Current Chairman of the Department of Ophthalmology of Our Lady of Caysasay Medical Center.

Abstract:

This is a case report of an 80 year old female presented with a bleeding hyperpigmented mass over the left upper eyelid. Gradual increase in the size has been observed over 4 years. Prior consult at a tertiary hospital and incision biopsy revealed carcinoma. She was advised surgery but refused and was lost to follow-up. On examination a 5 x 4mm hyperpigmented ulcerated mass was seen on the lateral aspect of the left upper lid. Upon removal of the superficial crust, multiple live maggots were seen swarming within the ulcerated lesion. Impression was Orbital Myasis, left t/c Basal Cell Carcinoma. Intravenous Ampicillin- Sulbactam 250mg/IV every 8 hours and IV Ketorolac 30mg/IV every 8 hours and a single dose of Mebendazole 500mg/tab were given. Orbital MRI was advised however patient refused due to lack of funding. She underwent debridement and biopsy of the lesion with manual extraction of the maggots. Xylocaine spray was observed to immobilize the larvae. Vaselinized (Petroleum Jelly) gauze was placed over the lesion in order for the larvae in deeper tissues to come out. Histopathology confirmed Basal Cell Carcinoma. Orbital Myasis is a rare condition that causes massive tissue destruction and orbital inflammation. Management options consist of mechanical removal of the larvae, antihelminthic therapy, surgical debridement and orbital exentration for extensive lesions

Biography:

Abstract:

Aim: To reduce astigmatism, increase corneal volume and improve visual acuity. Methods: A retrospective, single-surgeon, single centre, clinic-based study of a surgical procedure on twenty-four eyes of fourteen patients diagnosed with stage-III or stage IV keratoconus. Paired arcuate keratotomy coupled with modified circular keratotomy was performed at a single center by a single surgeon as an outpatient procedure with local anesthetic in a minor surgery room. Modified circular keratotomy was performed 7 mm from the papillary centre with depth of incision ranging between 70% and 90% of corneal thickness. Arcuate keratotomy was performed 2.5mm from the papillary centre with the depth of incision at 90% of corneal thickness. Angular length of the arcs ranged between 60° and 120° depending on the astigmatic power of the cornea. Results: Astigmatism decreased in 87.5% of the 24 treated eyes, increased in 8.33% and did not change in 4.17%. Corneal volume increased in 91.66% of the 24 eyes and decreased in 8.34%. Visual acuity improved in 100% of the eyes; there was a mean improvement of 59% from preoperative visual acuity, 8.34% of the treated eyes reaching a visual acuity of 1.0 (20/20) with correction. No complications occurred during or after surgery. No suturing was performed and there was no rupturing at incision sites. There was statistical significance difference between pre-sph against post-sph (P=0.001). Also between pre.cyl against post.cyl (P=0.005), there was no significance difference between pre-axis against post-axis (P=0.05). Conclusion: Paired arcuate keratotomy coupled with modified circular keratotomy should be considered as an intervention before performing keratoplasty.

Biography:

Jennifer Shum Wei Huen obtained her MBBS degree at the University of Hong Kong and is currently a Clinical Assistant Professor at her Alma Mater. Her subspecialty interest lies in glaucoma and had co-authored a book chapter in the field.

Abstract:

Consensual ophthalmotonic reaction (COR) was first described in 1924. Studies following monocular application of glaucoma drops showed a drop in fellow eye intraocular pressure (IOP). However, studies following trabeculoplasty & monocular surgery showed heterogeneous results. The purpose of this study is to 1) investigate COR in Chinese patients who have received monocular filtration surgery. 2) investigate COR in rabbits underoing monocular selective laser trabeculoplasty (SLT) Methods: A retrospective review of filtration surgeries performed in Queen Mary Hospital from 2014-2015 was conducted. IOP in both eyes was documented preoperatively and postoperatively up to 2 weeks. 12 rabbits underwent monocular SLT. IOP was measured over both eyes up to 1week after SLT. Results: COR was observed in Chinese patients undergoing monocular filtration surgery and rabbits receiving monocular SLT.

Biography:

Nidan Qiao has completed his MD at the age of 25 years from Fudan University. He is the neurosurgeon of Huashan Hospital, the largest neurosrugical center in China. He has published 5 papers in reputed journals.

Abstract:

Purpose: Retinal nerve fiber layer (RNFL) will show retrograde degeneration following damage to the optic nerve or the optic tract in patients with pituitary adenoma. RNFL changes after surgery have not been studied thor- oughly in patients with the transsphenoidal surgery and patients with the transcranial surgery. Methods: Thirty-seven patients with pituitary adenoma were recruited from Huashan hospital between September 2010 and July 2014. Patients were divided into two groups: the transsphenoidal group and the transcranial group. Before surgery, 3 and 9 months after surgery, follow-up optic coherence tomography were conducted. Results: Twenty-one patients underwent transsphenoidal surgery and 16 patients underwent transcranial surgery. No obvious difference were observed between these two groups before surgery. The mean RNFL thickness did not change significantly in patients who underwent transsphe- noidal surgery: 91.1 before surgery, 92.7 at 3 months after surgery (p = 0.392) and 92.8 at 9 months after surgery (p = 0.395). The mean RNFL thickness decreased in patients who underwent transcranial surgery: 93.6 before surgery, 86.1 at 3 months after surgery (p = 0.000) and 88.1 at 9 months after surgery (p = 0.005).
Conclusions: In the short time follow-up, there was no change of RNFL thickness in pituitary adenoma patients underwent transsphenoidal surgery, but a decrease in patients underwent transcranial surgery.

Biography:

Sinumol Thulaseedharan has completed her MBBS in 1995, DO in 1998, MS in 1999 from Kerala University, India and DNB in 2000 from National Board. She is presently the Assistant Professor in Govt. Medical College, Thrissur, Kerala. She had won the Best Paper Award in Anterior Segment from Kerala State, Runner up prize in ASCRS Video Film Festival, SFO, 2013 and one among the top 8 scientific video film producers in All India Ophthalmic Conference 2014.

Abstract:

This is a 1-point scleral fixation of IOL in tunnel bed when there is inadequate capsular bag support for the IOL. This technique can be used as a primary procedure when there is a large posterior capsular rent or a bag subluxation. It can be used as a secondary procedure of IOL implantation in aphakias with some capsular support in the opposite sulcus for the other haptic. This is a better option for managing subluxated or dislocated IOLs as we can fixate the same IOL without explanting it. The technique uses the available capsular remnant to support the leading haptic and an easy single scleral fixation suture to support the trailing haptic. Scleral fixation of the trailing haptic with 9-0 prolene is done in the sclera-corneal tunnel bed 0.75mm behind the limbus. There is no need for preparation of separate scleral beds for fixation. This saves time and provides adequate stability for the IOL without much manipulations or complications. This procedure can be done with routine PC IOLs –rigid/ foldable and single piece / three piece IOLs.

Biography:

Debasmita P Alone has completed her PhD from Cytogenetics Laboratory, Banaras Hindu University and Post-doctoral studies at Laboratory of Molecular Biology, National Institute of Mental Health, Bethesda, USA. She is leading the Molecular Genetics Laboratory, School of Biological Sciences, NISER, a premier institute for research and teaching in India. Research focus of her newly found laboratory is on molecular genetics of FECD and Psuedo-exfoliation in India. She has published in reputed Opthalmology journals of Investigative Opthalmology and Visual Science as well as Experimental Eye Research.

Abstract:

Fuchs’ endothelial corneal dystrophy (FECD) is a progressive deteriorative condition of corneal endothelial cells that predominantly affects women and onsets in the fourth to fifth decade of life. As an autosomal dominant and heterogeneous disease, FECD displays a peculiar trait of corneal guttata formation and excrescences from the Descemet membrane (DM) which are clinically detected using specular microscopy. So far, many genes have been attributed to cause this disease, thereby revealing its genetic complexity. With respect to Asian ethnicity, not many studies have been done to elucidate demographic specific genetic contributors for the disease. Transcription factor 4 (TCF4), that encodes for E2-2 protein, a group of E protein transcription factors known for cellular growth and differentiation, is one such gene that has been associated with this disease. Our recent study substantiates the fact that the intronic tri-nucleotide repeat expansion in this gene is a major contributing factor for the disease pathogenesis. In search of other genetic signatures for this disease, our recent findings suggest that intronic polymorphisms in TCF8 and FEN1 genes have strong associations with the disease in Indian population. Ours is the first report to identify a polymorphic marker for TCF8 gene in association with FECD, thereby rendering a stronger genetic load upon TCF8 for being a causative agent for the disease. Association of FEN1 vouches for the role of oxidative stress as one of the contributing aspect for the pathogenesis of FECD.

Biography:

Dr. Praveen Kumar has completed his MBBS from Grant Medical College and Sir J.J. group of Hospitals, Mumbai and MS (Ophthalmology) from Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India. He is senior resident at JIPMER, an institute of national importance, India. He has published various papers in reputed national and international journals.

Abstract:

Objective: To identify the effects of chronic alcohol and/or tobacco use on retinal nerve fiber layer (RNFL) thickness and to find the association between severity of addiction with RNFL thinning. Design: Case control study at tertiary care centre in southern India. Methodology: Cases included alcohol and/or tobacco users for at least 5 years. Severity of alcohol and tobacco dependence was graded by Alcohol Use Disorders Identification Test (AUDIT) and Fagerstorm Nicotine Dependence (FTND) scale respectively. Age and gender matched individuals without addictions were taken as controls. RNFL thickness was measured using Stratus Optical Coherence Tomography (OCT). Outcome measures: RNFL thinning by OCT. Statistical analysis: Differences in RNFL thickness between cases and controls were analysed using Mann-Whitney test. Statistical significance was considered with p ≤ 0.05. Effect of alcohol and tobacco consumption on RNFL thickness was analysed using STATA 11 (Statacorp, Texas) and SPSS version 20. Results: A total of 200 eyes of cases and controls respectively were included. Statistically significant RNFL thinning was noted in all quadrants except nasally. Significant RNFL thinning was seen with increased FTND Scale. RNFL thinning was seen with higher AUDIT scale, but this was not statistically significant. Conclusion: People who are addicted to tobacco use are likely to have RNFL thinning. Authors recommend that OCT can be used as feasible preclinical tool to screen RNFL thinning among chronic tobacco and alcohol users.

Biography:

She has completed her graduation in medicine (M.B.B.S) from Mahatma Gandhi Missions Medical College, Mumbai, India at the age of 23 years from Maharashtra University of Health Sciences, Nasik, India. I am specializing in Ophthalmology from Smt.Kashibai Navale Medical College and General Hospital, Pune, India. She started her specialization in August 2013. She has published 3 papers, presented 10 papers and 12 posters at both National and International Conferences.

Abstract:

A hospital based study was conducted on 100 eyes at a tertiary care centre, that underwent clear corneal phacoemulcification with temporal incision and implantation of intraocular lens implantation. 50 eyes had rigid and 50 had foldable intraocular lens implantation irrespective of the type of astigmatism. The length of incision in patients with foldable was 2.8mm and was extended to 5.5mm in patients with rigid intraocular lens. Keratometric and Surgically induced astigmatism was assessed on day 1, 7 and 42. We found that there was no statistically significant difference in visual outcome and surgically induced astigmatism in two groups on day 1, 7 and 42. There was no significant difference in Keratometric Astigmatism in two groups on day1 and 7. The Keratometric Astigmatism was significantly different in two groups on day 42 (P value-0.007), the patients with rigid intraocular lens implant had significantly more astigmatism on day 42 than those with foldable intraocular lens implant. Pre-operatively majority of the patients had against the rule type of astigmatism. It was observed that there was a shift from against the rule type to with the rule type of astigmatism in both the groups. The shift in the type of astigmatism was found to be more in patients with rigid intraocular lens implantation than those with foldable intraocular lens implantation (4%). We found that rigid intraocular lens implants which are cost effective can be beneficial in low socioeconomic set up with no potential disadvantages and side effects.

Biography:

Abstract:

200 patients selected from January 2015 to July 2015, were randomly allocated to two groups of 100 : Group A underwent polishing of the posterior capsule and retro-IOL irrigation-aspiration after IOL insertion while Group B underwent smooth uneventful phacoemulsification and in-the-bag IOL insertion but without polishing of the bag after IOL insertion. Post-operative assessment by slit-lamp and anterior segment OCT was done at 1 week, 1 month , 3 months and 6 months. Slit-lamp examination was done for any anterior chamber reaction. Early post-operative capsular block syndrome was diagnosed by postoperative myopia or refractive surprises when a shallow anterior chamber and a distended capsular bag with IOL separation are found. Post-cataract opacification was seen on slit-lamp examination. RESULTS: Group A did not have any cases of early post-operative CBS and 4 cases of PCO at 6 months. Group B had 6 cases of early post-operative CBS and 13 cases of PCO at 6 months. The difference was statistically significant both for early post-operative CBS (p=0.0289) and PCO at 6 months (p=0.0398). CONCLUSIONS: Polishing of the posterior capsule and retro-IOL irrigation-aspiration after IOL insertion significantly decreases the incidence of of early post-operative capsular block syndrome (CBS) and post-cataract opacification (PCO).

Biography:

Zeyad A Alzaben received his Bachelor degree in Optometry (2013) at the Jordan University of Science & Technology (JUST), and the first MSc degree in Science of Vision and Optometry (2014) at the Universitat Politècnica de Catalunya (UPC), and the second MSc degree in Visual Rehabilitation (2014) at Universida de Valladolid (UVa) / Medicine Faculty. He is a PhD candidate in Optical Engineering doctoral program (2014-2016) at Universitat Politècnica de Catalunya (UPC). He is currently employed as full-time optometrist at the Department of Low Vision of Optipunt Eye Clinic (www.optipunt.com). He has conducted two new researches about normal patients and patients affected by pathological myopia using OCT and MAIA microperimeter, waiting the acceptance letters to be published. He is a student of Corporate Program for Management Development / Advanced Program for Optics Management in ESADE Bussines School in Barcelona (2014-2017). His aim is to utilise his skills to improve his experiences and keep learning more with respect to the challenges about using his valuable assessments.

Abstract:

Optical coherence tomography (OCT) is a useful non-invasive technique to assess the retina without the need for pupil dilation. In particular, the macular and optic disc areas may be explored in detail and with a high level of spatial resolution. A transversal study was designed in which a spectral-domain 3D-OCT-2000 was employed to evaluate several retinal parameters in a sample of 37 young Caucasian adults aged between 12 and 23 years (spherical equivalent from -3.00 to +4.00 D). Normal inter-ocular asymmetry values were determined and 95% inter-ocular difference tolerance values were obtained. Inter-ocular statistically significant differences were uncovered in mean and superior RNFL thickness, as well as in central macular thickness, with larger values in the left eye in all instances, and with tolerance limits of inter-ocular asymmetry (2.5th and 97.5th percentiles) of -9.00 µm to 6.00 µm, -28.00 µm to 9 µm and -39.00 µm to 29.00 µm, respectively. In addition, statically significant differences were found between males and females in mean thickness of the retinal nerve fiber layer (RNFL) in the right eye. These findings give support to the exploration of the normal asymmetries of the retina as an effective approach for an early detection of pathologies such as glaucoma. Differences in instrumentation and sample characteristics compromise direct comparison with published research and warrant the need for further studies.

Biography:

Raghad Alrasheed, a 5th year medical student from King Saud University, Saudi Arabia.

Abstract:

Objectives: To evaluate the current knowledge, awareness, and to assess practices among primary care physicians working in primary care centers in Riyadh, regarding Diabetic Retinopathy (DR).
 Methods: We conducted a cross-sectional study covering 46 randomly selected primary care centers in Riyadh during October 2015. A Self-administered questionnaire was distributed to primary care physicians containing 3 main sections. The first section focused on participants’ demographics and professional background. The second section contained multiple-choice questions on knowledge related to diabetes and DR. A Score of one was given for each correct answer and zero for the wrong or did not know answers. The last section was to assess physicians’ practices. Data was analyzed using SPSS.
 Results: A total of 216 general physicians completed the questionnaire. The mean overall knowledge score for all the respondents was 57±14 out of 100. Knowledge was significantly higher for physicians with >15 years of practice (59±13 vs. 54±15, P=0.04). Male physicians scored better than females, 13% vs. 6.7% respectively scored >75. A defect was noticed in area of screening and follow-up of type 1 diabetes, only 24% of physicians correctly referred patients with type 1 diabetes to an ophthalmologist, whereas 71% referred patients with type 2 diabetes as recommended by the guidelines. Another defect area was detected in treatment options. Majority agreed on the use of laser photocoagulation as treatment. However, only 1/5 of participants were aware of the use of steroids and anti-VEGF as possible options. 65% of physicians claimed the capability of using an ophthalmoscope, 74% of them have examined their patients with it. Conclusion: Our study uncovered areas of defects in knowledge among general practitioners regarding diabetes and DR. Therefore; future seminars on diabetes emphasizing the proper ophthalmological screening and management of patients are necessary.

Biography:

I have completed my MBBS at the age of 24 years from Gujarat University and am currently pursuing post graduate study from M & J Western Regional Institute of Ophthalmology.

Abstract:

We present a case of an 8 year old male who had severe vision loss in his right eye 2 months prior to examination. Best corrected visual acuities were no perception of light in right eye and 6/9 (without correction) in left eye. Pupil evaluation revealed a dilated pupil in right eye and a normal reactive pupil in left eye. Exotropia was visible on gross clinical observation. Biomicroscopy showed moth eaten iris with anterior capsular changes and posterior sub-capsular opacity in right eye. Dilated fundus examination showed serous retinal detachments in the right eye with dilated veins, telangiectatic vessels, hemorrhages and sub-retinal exudates. The retina of the left eye was normal. Retinoblastoma was ruled out with further diagnostic testing. Coats’ disease is definitively identified based on clinical assessment, ultrasonography and laboratory tests. Because of its preponderance to mimic retinoblastoma, application of these tests can differentiate long standing Coats’ disease from neoplastic growths. Treatment of this disorder is based on the extent of disease at presentation.

Biography:

Mohd Radzi Hilmi is currently pursuing his PhD in Health Science (Optometry) at International Islamic University Malaysia (IIUM). He has completed his Master of Optometry (MOptom) from University of New South Wales (UNSW) Australia in 2011. He has obtained his first degree in Optometry in 2010 from IIUM. His research interests are in anterior segment imaging and corneal and external eye diseases.

Abstract:

Pterygium is an abnormal growth on the eye which may cause to severe visual disturbance and is highly prevalent in countries close to equator. However, there is lack of research which addresses the severity and properties of the tissue. Mimicking human color perception has commonly adopted using RGB color space; however, it is still inadequate. In this research work, we propose CIELab color space and vesselness filter to objectively quantify redness of 68 pterygium fibrovascular images and compare the results with other 12 color spaces. Experimental results show that CIELab color space shows better representation of human color perception (correlation coefficient=0.68) compared to using vesselness filter (correlation coefficient=0.43). CIELab can serve as a basis for future work on to automate pterygium clinical grading based on tissue redness.

Biography:

Dr. Kendrick Co Shih, MBBS MRCSEd Clinical Assistant Professor in Ophthalmology, The University of Hong Kong, Hong Kong Expertise: Early and Late Management of Ocular Surface Inflammatory Disorders
Dr. Richie Chiu-Lung Chan, MBBS FHKCS (Plastic Surgery) Specialist in Plastic Surgery, Queen Mary Hospital, Hong Kong Expertise: Acute and Long-Term Systemic Care for Burn Patients

Abstract:

The focus of the instruction course is Stevens-Johnson syndrome and toxic epidermal necrolysis. The course is divided into 1) immediate and early medical and surgical care of patients with SJS/TEN 2) long-term care of late ocular manifestations 3) surgical options for visual and ocular surface rehabilitation. This instruction course is intended for general ophthalmologists who are keen to develop a systematic and effective approach in the management of severe inflammatory ocular surface disease. It is also intended for the cornea/anterior segment subspecialists who wish to expand their surgical skills. The surgical procedures discussed for this session will include amniotic membrane transplantation, eyelid reconstruction and keratoprosthesis. Objectives: At the conclusion of this course, the attendee will be able to 1) Describe the appropriate immediate and early care for patients with SJS/TEN 2) Recognize long-term ocular complications of SJS/TEN and describe appropriate management 3) Describe patient selection and surgical options for visual rehabilitation.

Biography:

Dr. Richie Chiu-Lung Chan, MBBS FHKCS (Plastic Surgery) Specialist in Plastic Surgery, Queen Mary Hospital, Hong Kong Expertise: Acute and Long-Term Systemic Care for Burn Patients

Abstract:

The focus of the instruction course is Stevens-Johnson syndrome and toxic epidermal necrolysis. The course is divided into 1) immediate and early medical and surgical care of patients with SJS/TEN 2) long-term care of late ocular manifestations 3) surgical options for visual and ocular surface rehabilitation. This instruction course is intended for general ophthalmologists who are keen to develop a systematic and effective approach in the management of severe inflammatory ocular surface disease. It is also intended for the cornea/anterior segment subspecialists who wish to expand their surgical skills. The surgical procedures discussed for this session will include amniotic membrane transplantation, eyelid reconstruction and keratoprosthesis. Objectives: At the conclusion of this course, the attendee will be able to 1) Describe the appropriate immediate and early care for patients with SJS/TEN 2) Recognize long-term ocular complications of SJS/TEN and describe appropriate management 3) Describe patient selection and surgical options for visual rehabilitation.

Biography:

Dr Alex Ng obtained his MBBS degree from the University of Hong Kong in 2008. He received his basic and 2 years of higher surgical ophthalmology training in the United Christian Hospital. In October 2013, he joined the Department of Ophthalmology, the University of Hong Kong as clinical assistant professor, with a research interest in anterior segment disorders including refractive cataract surgeries, corneal disorders and ocular surface diseases.

Abstract:

Synopsis: This course will discuss the clinical use of corneal collagen crosslinking in the treatment of a wide spectrum of diseases including corneal ectasia, infective keratitis, bullous keratopathy and cystic bleb leakage. Various techniques of crosslinking will be discussed, including use of accelerated, pulsed and trans-epithelial crosslinking. Objective: At the conclusion of this course, the attendee will be more confident in selecting the most suitable technique of crosslinking in the treatment of keratoconus. They will also have a better understanding on the use of crosslinking in other anterior segment disorders including leaking cystic bleb, bullous keratopathy and infectious keratitis.