Jennifer Joy Y Santos-Rayos
University of the Philippines, Philippines
Title: Macular Pigment Optical Density in Filipinos with Age-Related Macular Degeneration After Lutein and Zeaxanthin Supplementation: A Non-Randomized Comparative Study
Biography
Biography: Jennifer Joy Y Santos-Rayos
Abstract
Objectives: This study determined the baseline Macular Pigment Optical Density (MPOD) for those without retinal disease (group 1), those with non-exudative Age-related Macular Degeneration (AMD) (group 2), and those with exudative AMD (group 3). The effect of Lutein-Zeaxanthin supplementation was also determined. Method: For this study, 120 participants completed the baseline MPOD measurement and supplementation of Lutein (12 mg/day) and Zeaxanthin (1 mg/day) for 90 days. Factors of MPOD were also obtained through a questionnaire. Results: The mean baseline MPOD for the three groups were as follows: 0.382 DU (+ 0.10) for group 1, 0.333 DU (+0.07) for group 2, and 0.283 DU (+0.07) for group 3. Baseline MPOD of group 1 was statistically higher than baseline MPOD of group 2 (p=0.021) and group 3 (p=0.001). Mean baseline MPOD of group 2 is significantly higher than group 3 (p=0.017). MPOD after supplementation was also statistically significant using one-way repeated measures ANOVA. For Group 1, the MPOD levels increased significantly every month of supplementation, except on the third month when it did not reach statistical significance (p=0.001, p=0.003 and p=1.00 respectively). For Groups 2 and 3, MPOD levels increased significantly every month (group 2 p=0.021, p=0.010, p=0.008; and group 3 p=0.000, p=0.026, and p=0.00). Of the factors tested, weak and non-significant correlation was found. Conclusion: Patients without retinal disease have higher MPOD than patients with Non-neovascular AMD, and an even higher MPOD than patients with neovascular AMD. Supplementation increased the MPOD for three months.