Day 2 :
Keynote Forum
Jun Xu
Sun Yat-Sen University, China
Keynote: Big data, high performance computing and Pharmaceutical innovations
Time : 09:30-10:15
Biography:
Jun Xu has completed his PhD from University of Science & Technology of China and Post-doctoral studies from Australian National University and McGill University. He is the founding Director of Research Center for Drug Discovery (RCDD), which consisits of Bio/Chemo-informatics lab, Drug Design lab, Phyto/Medicinal Chemistry lab, Structure Biology lab, and Drug Screening lab. He has published more than 80 papers in reputed journals and has been serving as an Editorial Board Member of a number of reputed international journals.
Abstract:
In the pharmaceutical research, high throughput scientific experiments, high performance computations, automated information acquisition and office automation, and scientific publications and patent literatures, are four sources that produce big data. The biomedical big data brings greater challenges because conventional hardware and software are unable to handle it due to limited memories and extreme computing complexity. With cloud high performance computing (cHPC) technology, the challenges can be resolved by parallelizing existing chemoinformatics and bioinformatics programs. Biomedical big data is usually scattered, incomplete, low signal/noise ratio, and involving in sophisticated relations among objects. Combining multiple machine learning approaches, such as, naive Bayesian learning, support vector machine and recursive petitioning, are used in biomedical big data mining projects. This talk outlines current progress in biomedical big data processing technology including parallelized and GPU-accelerated molecular dynamics simulation technology, enhanced molecular docking technology, new parallelized algorithms for shape-based virtual screening, free energy landscape calculations, and machine learning algorithms for pharmaceutical innovations.
- Track 3: Research Pharmacists Track 6: Prarmacists and Practice Track 10: Managed Care Pharmacists
Location: Quay 1 Main Hall
Chair
Paul C. Ho
National University of Singapore, Singapore
Session Introduction
Hyeon-Ho Park
Pukyong National University, Republic of Korea
Title: Characterization and fabrication of Ecklonia cava phlorotannin/PVA blended hydrogel patch
Time : 10:45-11:15
Biography:
Hyeon-Ho Park has studied in Biomedical Engineering and Chemistry Department from Pukyoung National University in Busan, Korea. He applied double majors and holded qualification in it. He also has worked in Marine Biomedical Science lab where he is able to experiment constantly on cells, synthesis, extraction and others and then he applied for a Master’s course in the same university and lab.
Abstract:
When skin wound occur, hydrogel patches have been generally used as wound dressing for wound healing. Poly(vinyl alcohol) (PVA) is one of the commonplace hydrogel patch’s materials which have non-toxicity, non-carcinogenicity, biocompatibility and easy processing and Ecklonia cava (EC) is brown alga which is widely found in Jeju Island in Korea. EC has compounds have been associated with a variety of biological activites. It has various bioactivity including radical scavenging, immunomodulatory, anti-inflammatory, bactericidal activity and potential for skin whitening effect and it stimulates proliferation of normal human dermal fibroblast-neo cells (NHDF-neo). We designed to blend PVA hydrogel patches with EC phlorotannin and fabricated without chemical crosslink by using freezing/thawing method to make more effective PVA hydrogel-patches on wound healing. Then, we evaluated swelling property in water and mechanical property to know hydrogel patch’s mechanical characterization and intermolecular interactions of hydrogel affected by EC phlorotannin were elucidated using FTIR and cell proliferation was measured by staining nuclear with Hoechst. As a result, EC phlorotannin/PVA hydrogel patches had high water absorption than those of pure PVA hydrogel patches. But, mechanical property was decreased, being proportional to EC phlorotannin concentraion and FTIR result demonstated that hydrogel pathches including EC phlorotannin increased hydroxyl group in spite of the fact that EC phlorotannin do not affect PVA hydrogel’s intermolecular interactions. Then, cell proliferation is increased on condition which have with EC phlorotannin hydrogel. Therefore, our results suggest that EC phlorotannin/PVA hydrogel patch will be effective wound dressing than that of pure PVA for wound healing.
Van-Tinh Nguyen
Pukyong National University, Republic of Korea
Title: On the characterization of Fucoidan on Sodium alginate/gelatine scaffolds for anti-inflammation in neuroscience
Time : 11:15-11:45
Biography:
Van-Tinh Nguyen has completed his PhD from the Department of Biomedical Engineering, Pukyong National University, Korea. He has completed his graduation in 2012 from the University of Chosun and his current research interests include: Isolation, safety and bioavailability of bioactive materials and; Development of marine-integrated cells and tissue regenerative biomedical substances.
Abstract:
Microglia, which is the immune cells of the central nervous system (CNS). Overexpression of inflammatory mediators by microglia can induce of several neurological diseases. Thus, bases on the requirement of the key in neural tissue engineering are to develop materials with little or no effect to neuroinflammation. In this study, we have developed a method to create three-dimensional (3D) scaffolds by added fucoidan into porous sodium alginate/gelatin (SaGFu). For mechanical characterization such as in vitro degradation, stress/strain, swelling test, and pore size were measured. Moreover, we studied the neuroinflammatory effects of SaGFus on BV2 microglia cells. The effect of gelatin and fucoidan content on the various properties of the scaffold is investigated and the results showed that mechanical properties increased porosity and swelling ratio to the increase in the gelatin and fucoidan adding, while the in vitro biodegradability decreased. The average SaGFus diameter attained by fabrication of Sa/gelatin/fucoidan main ranged from 60±18 to 100±16 um with high porosity (64.44–78.30 %). Cell culture tests, carried out using gelatin 2.0 % and 4.0%, showed a good cell proliferation more than 60–80 % of sodium alginate alone. Following stimulation with 0.5 μg/mL LPS, microglia cultured in 3D SaGFus decrease their expression of NO. SaG2Fu and SaG4Fu also inhibited the activation and translocation of p65 NF-κB protein levels, resulting in reduction of NO and PGE2 production. These results provide insights into the diverse biological effects and open new opportunity for the applications of SaGFus in neuroscience
Gun-Woo Oh
Pukyong National University, Republic of Korea
Title: Fabrication, characterization and determination of biological activities of poly (ε-Caprolactone)/chitosan-caffeic acid composite nano/microfiber mat for wound dressing application
Time : 11:45-12:15
Biography:
Gun-Woo Oh has studied in Interdisciplinary Program of Biomedical, Mechanical & Electrical Engineering from Pukyoung National University in Busan, Korea. He also has worked in Marine Biomedical Science lab where he is able to experiment constantly on cells, synthesis, extraction and others, and the adviser is Won-Kyo Jung and then he applied for Doctoral course in the same University and lab.
Abstract:
Electrospinning In the present study, we designed composite nano/microfiber mats consisting of poly (ε-caprolactone) (PCL), chitosan (CH), or chitosan-caffeic acid conjugate (CCA) fabricated by an electrospinning technique for wound dressing application. The average diameters of PCL, PCL/CH, and PCL/CCA composite nano/microfiber mats are 1.30±1.07, 1.20±1.22, and 0.94±0.68 μm, respectively. Based on UTM analysis, the PCL/CCA composite significantly increases tensile properties compared with the PCL and PCL/CH composites. Additionally, initial cell attachment and cell proliferation of the composites using neonatal human dermal fibroblast (NHDF-neo cells), as well as the anti-microbial effect against Staphylococcus aureus, was investigated. The PCL/CCA composite shows significantly higher initial cell attachment and cell proliferation than the PCL and PCL/CH composites, and a high anti-microbial effect was observed compared to the PCL and PCL/CH composites. Based on these results, the CCA is demonstrated to be good supplemental bioactive agent for wound dressing applications and skin tissue engineering.
Hadeer Akram Abdul Razzaq
University Sains Malaysia (USM), Malaysia
Title: The hazards of multiple pharmaceutical excipients…the unnoted polypharmacy
Biography:
Hadeer Akram AbdulRazzaq has completed his PhD at 2013 in School of Pharmaceutical Sciences, Universiti Sains Malaysia (USM). He conducted many researches in fields of clinical pharmacy and pharmacy practice. He is Assistant Professor in University Sains Malaysia (USM). He published more than 70 papers and abstracts in reputed journals and has been served as Editorial Board Member and active reviewer in several journals. He is member in American College of Clinical Pharmacy (ACCP), American Heart Association (AHA), International Society of Pharmacovigilance (ISOP), and Asian Pacific Society of Respirology (APSR).
Abstract:
In spite of the availability of polypharmacy guidelines for the cardiac pharmacotherapy, there has yet to be a guideline for the polypharmacy of pharmaceutical excipients. This study aims to determine whether there is an impact on the multiple uses of pharmaceutical excipients and to detect the polypharmacy of pharmaceutical excipients according to the severity of the adverse drug reactions (ADRs). There were 504 cardiac patients involved and attended at the cardiac clinic of Penang General Hospital, Malaysia. A validated self-reporting questionnaire used to collect 56 symptoms, while serious ADRs were collected from their progress file. All information about the pharmaceutical excipients was collected either from medications’ leaflets or directly from the manufacturers. The result of the study showed that polypharmacy and severity of excipients' ADRs depended on the number of the same type of excipient. The number of ADRs reported by patients was 22, 54, 42, 38, and 42 for those who received 5, 10, 15, 20, and 22 excipients respectively. Moderate and severe complaints of ADRs were significantly increased if the number of active and excipients was higher than 11 and 15 respectively. Current study predicted the polypharmacy of excipient to be 10 (alone) and 15 (with active ingredients). Pharmacists’ awareness needs to be improved by implementing education interventional programs. Beside this, the prescriptions are needed to be checked especially the pharmaceutical excipients to avoid the polypharmacy of pharmaceutical excipients in those use chronic multiple therapies to minimize the incidence of ADRs.