5^thAsian Obesity Specialists and Endocrinologists Annual Meeting July 11-12, 2016 Kuala Lumpur, Malaysia

Biography:

Path Manthan is working as Associate  Professor  in the Australian University

Abstract:

Therapeutic Life Style-Change (TLC) has been a widely accepted and recognized technique to combat the modern disease of civilization. TLC diet, aerobic, anaerobic exercise, shaping, modeling, reinforcing techniques, life-style modification, information, education and communication system development are the prime interventions to fight obesity. It has been revealed that TLC technique reduce excess fat e.g. LDL, VLDL Cholesterol and Triglyceride level, and decrease cardiac mortality rate, improve cardiac efficiency, longevity and prevent stroke and their long term complications. It has been recognized that the consequence of obesity can be prevented by adopting a planned comprehensive approach. Research on traditional herbal formulation for weight loss, genetic counseling and cellular modification of non-modifiable factors are the painstaking issues to the scientific communities.

Biography:

Zerrin Orbak, MD, is a graduate of Ataturk University School of Medicine, where she completed her residency in Pediatrics before going to Ege University as a Post-doctoral fellow in Pediatric Endocrinology. She has published more than 100 original articles, chapters and reviews.

Abstract:

Childhood is an important opportunity to develop healthy patterns for life and prevent weight problems. Children who are overweight or obese can benefit from healthy eating and regular physical activities (exercise). Children may use different methods for weight loss like adults. This study was aimed to determine methods for weight loss in children with overweight and obese. School children aged 6-16 years were included in this study. Height and weight measurements of 1695 children were evaluated and body mass index values were calculated. After that questionaire forms were given for evaluating weight loss methods. Of all children, 99 (5.8%) were overweight, 72 (4.2%) were obese and 198 (11.7%) were underweight (BMI <5 percentile). The ratios of any methods used for weight loss were 2.6%, 4.1% and 10.0% in normal, overweight and obese groups, respectively. This result was statistically significant (p<0.01). While 7.0% of overweight children, 15.0% of obese children practiced diet, exercise and alternative methods for weight loss, 2.9% of children with normal weight interestingly reported diet, exercise and alternative methods. The most common alternative methods was herbal tea (green tea, fennal tea, chamomilla, sage tea ve mix herbal tea). Normal, overweight and obese school children drunk herbal tea as 1.4%, 4.0% and 6.9%, respectively. Other methods were eating parsley, peppermint and drinking vinegar in the morning during a fast. Alternative methods were significantly frequent in obese children (p<0.001) and in older age group (11-16 age) (p<0.01). As a result the most common method was herbal teas among school children. Although effects on weight loss and adverse reactions of these methos is not described well, alternative weight loss methods are very common among overweight and obese school children even among normals. Education related to professional advice from a doctor or dietitian can help reach and maintain a healthy weight.

Biography:

Fei Ye graduated from School of Basic Medicine, Peking University Health Science Center. She is engaged in her scientific research focusing on the pharmacology of anti-metabolic syndromes. She has published more than 40 papers, and has served as an editorial board member of Journal of International Pharmaceutical Research, and as a committee in some professional associations. She presided some items supported by National Major Project on New Drug Innovation, Natural Science Funds of China, and State Administration of Traditional Chinese Medicine, respectively. She gets 6 patents authorization about the invention of new drugs.

Abstract:

The animal models with the similar clinic pathophysiological characteristics provided a wonderful foundation for the investigation of diseases. The metabolic syndrome (MS) is characterized with obesity, insulin resistance, and glucolipide metabolic disorders. To establish a standardized experimental evaluation system, the euglycemic-hyperinsulinemic clamp test, insulin tolerance test (ITT), and level of whole body insulin sensitivity index（ISWB）was used for the insulin sensitivity; the hepatichistological analysis, triglyceride content, microcirculation, and serum alanine amino transferase levels were for the fatty liver; the glucose tolerance test (GTT) and serum lipid profiles were for the glucolipide metabolic disorders; and the hyperglycemic clamp test was for the islet function, respectively. The DIO mice or DIO canine were induced by the modified high-fat-diet in C57BL mice or Beagle canine (with fructose drink), respectively. Then, the metabonomics of serum, liver and urine was analyzed. As the results, the characters of gradually aggravated obesity, insulin resistance, impaired glucose tolerance, and liver lipid accumulation were similar in both DIO mice and DIO canines; but for the serum lipid profiles, DIO canine, DIO mice and KKay mice ( a classical MS model), each has their own characteristics. The characters of high-fat-diet-induced obesity animal models, DIO mice and DIO canine, are analogous with the progress of the MS patients. Acknowledgements: This work was supported by National Major Special Project on New Drug Innovation of China (No. 2012ZX09103-101-063; 2012ZX09301002) and Open Fund of State Key Laboratory of Bioactive Substance and Function of Natural Medicines (No. GTZK201512).

Biography:

Vincent Chiew was graduated with Bachelor of Social Science major in Psychology minor in Business, concentration in health psychology, Carleton University, Ottawa, Canada.Vincent have 16 years of Cambridge Weight Plan business building experience with General Practioner, Slimming Center, Beauty Saloon, Gym Instructor and Individual Entrepreneur.Vincent have regularly invited by both medical and commercial organizations as speaker for bodyweight management and health awareness campaign.

Abstract:

Cambridge Weight Plan makes use of specially-formulated flavoured bars, soups and shakes to supply low-calorie diet ranging from about 400 to 1500 kcal or more per day. The products containing the necessary vitamins, minerals and trace elements to maintain balanced nutrition, can be used on their own as meal replacement in the very low calorie diet (VLCD) plan for fast weight lost or with (low-calorie) regular meal in the low calorie diet (LCD) plan for a more gradual weight loss or for weight maintenance. While on the program, we should also receive advice and support on healthy eating and exercise from accredited Cambridge Weight Plan Consultant. The Cambridge Weight Plan has gold-standard published clinical trials showing weight loss and weight maintenance over four years and sustained health benefits. Weight loss of 1 to 2 kg per week is possible. This can give a 15 kg weight loss, which is associated with a lessening of arthritic pain, sleep apnoea, psoriasis and better diabetes control, in 8 to 12 weeks. Weight loss of 10 kg or 10% of initial body weight (or more) can be maintained in compliant individuals. Recently, a global 8-country study (PREVIEW) on more than 2300 people with prediabetes showed that they lost an average 10.8 kg in 8 weeks on a Cambridge Weight Plan 810 kcal/d diet. This amount of weight loss can be associated with removal of ectopic fat from the liver and pancreas thereby reducing insulin resistance and improving insulin production, thus reversing prediabetes and early diabetes.

Biography:

Sherif Sabri: This author has nothing to disclosekhalid Selim: This author has nothing to discloseHazem El-Akabawy: This author has nothing to discloseMohammad Al Ghoraieb: This author has nothing to disclose

Abstract:

Background

The metabolic syndrome (MetS) is a clustering of risk factors associated with an increased risk for cardiovascular disease and type two diabetes mellitus. We aimed to identify the prevalence of MetS in patients with systolic heart failure (HF) and to determine the relation of its components to systolic HF.

Methods

A total of 100 patients with an ejection fraction 35% enrolled prospectively in this multicenter study. All recruited patients subjected to thorough history taking, clinical examination, chest Xray, electrocardiography, echocardiography, biochemical tests (fasting blood glucose, triglycerides, HDL-C, urea, creatinine, AST, ALT, & PT, T3 ,T4 ,TSH, complete blood picture, serum Na & K levels). Waist circumference; measured midway between the lower limit of the rib cage and iliac crest with nondistensible and flexible tape; was assessed in all included patients.

Results

Metabolic syndrome was prevalent in patients with severe systolic dysfunction. Hypertension, hyperglycemia, and visceral obesity were the most common component of MetS in patients with severe systolic dysfunction HF. In males with systolic dysfunction HF, the most prevalent components of MetS were hyperglycemia (70%) followed by hypertension (67%), and visceral obesity (58%). In females with systolic dysfunction HF, the most prevalent components of MetS were hypertension (75%), hyperglycemia (56%), and visceral obesity (50%). Prevalence of MetS did not differ with age group (< 65 yrs. & 65 yrs.). Low HDL-C was significantly present in patients above 65 yrs old (72%), whereas the other MetS components did not change significantly with age. The mean number of positive MetS components was 2.6, which was not significantly different between genders or with age. There was higher prevalence of ischemic heart disease in patients with MetS (74.2%), however the rest of MetS patients (25.8%) have no ischemic heart disease (either by history, ECG, or resting Echo) in which MetS may cause heart failure by mechanisms other than ischemic heart disease.

Conclusion

Metabolic syndrome is prevalent in systolic dysfunction HF patients. 

Biography:

Mahendra Narwaria has obtained his Post-graduate degree in General Surgery from B J Medical College, Ahmedabad in 1996. Subsequently, he pursued his interest in Surgical Gastroenterology and Laparoscopic Surgery at Sanjay Gandhi Post-graduate Institute (SGPGI), Lucknow. He is one of the pioneers of Bariatric Surgery in India and has performed more than 2000 Bariatric procedures till date. His patients have access to all possible services of Bariatric Surgery under one roof i.e., Asian Bariatrics Pvt. Ltd.

Abstract:

Morbid obesity is almost universally associated with non alcoholic fatty liver disease (NAFLD) and approximately half of the patients undergoing obesity surgery suffer with non alcoholic steatohepatitis (NASH). It is becoming a common cause of liver cirrhosis. Bariatric surgery can benefit obese patients with cirrhosis through weight loss and alteration of metabolic milieu as well as increase the eligibility of candidate for liver transplant. Accurate risk versus benefit analysis of each bariatric procedure in cirrhotic patients can be extremely challenging and currently there is lack of consensus among surgeons regarding safety of bariatric surgery in such patients with liver cirrhosis and the best bariatric procedure for them. The review shows an acceptably higher overall risk of complications and peri-operative mortality with bariatric surgery in cirrhotic patients. In this review, LSG and AGB appear to be safest bariatric procedure in obese patients with cirrhosis undergoing bariatric surgery. However, larger studies are needed on long term safety and efficacy of these procedures on cirrhotic patients to make clear recommendations. Surgeons must discuss the possibility of an unexpected intra-operative finding of cirrhosis preoperatively with all bariatric surgery patients and agree on a course of action to empower both patient and the surgeon.

Biography:

Aaltje E. Manampiring has completed his PhD at the age of 50 years from Hasanuddin University. She is a lecturer at faculty of Medicine Sam Ratulangi University.

Abstract:

Background: The prevalence of obesity is increasing in adults, adolescents and children. The increasing prevalence of obesity in the world was accompanied by an increase in the prevalence of metabolic syndrome. This study aims to determine the prevalence of obesity and metabolic syndrome in obese adolescents. Methods: This study was conducted with a cross-sectional design of high school students in North Sulawesi province of Indonesia. A total of 2248 students consisting of 865 men and 1383 women, aged 13-18 years, measurement of waist circumference (LP), blood pressure, lipid profile examination, and blood sugar levels. Subjects who are obese is the determination of the metabolic syndrome using the IDF criteria, 2007. Data were analyzed descriptively general method univariate analysis. Results: As much as 22% of subjects (494 students) are already obese centralist. From 210 obese subjects (28.9% of men and women as much as 71.1%) as much as 13.2% subject has Triglycerides ≥150 mg / dL, and as much as 81% in HDL levels below normal. 4.2% of subjects has GDP ≥100 mg / dL and 30.6% blood pressure ≥130 / 85 mmHg. The prevalence of metabolic syndrome in obese adolescents was 36.9%. Conclusion: The prevalence of adolescent obesity is 22% and 37% of obese adolescents met the criteria for metabolic syndrome. These findings may have important implications for prevention and intervention of adolescent obesity.

Biography:

Professor Kumagai has got Ph.D. degree from Saga Medical School, Japan. His research area includes health and exercise epidemiology for metabolic syndrome, cognitive decline, dementia, and mortality in community-dwelling population. He is a director of Institute of Health Science (2012-2013) in Kyushu University. He is also a chairman (1999-2011) and chief editor (2011-2015) of Japanese Association of Health Promotion, and vice president (1999-2011) and chief editor (2006-2010) in Japanese Society of Exercise Epidemiology. He has published more than 100 papers including review paper in reputed journals.

Abstract:

The purpose of present study was to clarify whether the muscle fiber composition and/or muscle oxidative enzyme activity are related to dietary body weight gain and abdominal fat accumulation. Genetically fast-twitch fiber dominant rats (FFDR) and control rats (CR) were divided into low-fat or high-fat diet groups: CR with a low-fat diet (CL); CR with a high-fat diet (CH); FFDR with a low-fat diet (FL); and FFDR with a high-fat diet (FH). After 6 weeks of following such diets, the body weight gain, abdominal fat content, food intake, muscle fiber composition and oxidative enzyme activities were estimated. The body weight gain in CH was higher than in the other groups and percentage abdominal fat in CH was also higher than in the other groups, while the energy intake did not differ among the groups. The percentage of type IIX fibers of M. gastrocnemius in FL and FH were higher than in CL and CH, and the type IIA fibers of M. soleus in FL and FH were higher than in CL and CH. The citrate synthase activity of M. plantaris in FL and FH were higher than CL. β-HAD activity in FL and FH were higher than in CL and that in FH was higher than CH. On the other hand, the enzyme activities of M. gastrocnemius and soleus were identical among the groups. The FFDR was more obesity-resistant than the CR after a high-fat diet. These results suggest that the muscle oxidative capacity rather than muscle fiber composition is a possible determinant of obesity.

Biography:

Sondos Harfil is a lecturer at the College of Health Sciences. Instructed several courses and memebrs in community associations and comittees. Completed her M.Sc. annd higher diploma in Biology from University of Jordan and currently enrolled in PhD program at University Sains Malaysia, Biomedicine Department. Her research interest in the field of gut mciorbiota and obesity.

Abstract:

Introduction: Obesity is a growing epidemic in many countries .There’s a remarkable developments in the investigation of obesity-induced insulin resistance. Low- grade inflammation is involved in the molecular mechanism of insulin resistance. Recently, the influence of changing gut microbiota has been investigated as contributing factor for obesity and metabolic aberrations. Obesity is associated with an altered gut microbiota in humans. The composition of the gut microbiota has been shown to differ in lean and obese humans and animals, and to change rapidly in response to dietary intervention. The gut microbiota may influence the development of obesity and type 2 diabetes which are characterized by low grade inflammation. These results support the emerging views that the gut microbiota contributes to metabolic disease by modulating host metabolism. Lipopolysaccharides (LPS) are released from the dead Gram-negative bacteria in the gut, and under conditions of gut damage can translocate into the circulation where it trigger an inflammatory response. LPS-binding protein (LBP) is another reactive biomarker formed in response to microbial translocation. LPS and LBP serum levels have been associated with obesity and with other cardiovascular and metabolic morbidities. There are growing evidences that the altered composition of the gut microbiota and the resulted endotoxemia are responsible for the rapid increase in obesity. Aims: The current review will discuss the recent research findings that have focused on the involvement of gut microbiota and metabolic endotoxemia in human obesity, and the potential role of dietary intervention to restore the normal gut microbiota. Conclusion: The studies indicated that the normal composition of the gut microbiota is altered with high fat diet. There are many studies that correlated the high levels of endotoxicity to low grade inflammation and the emergence of metabolic disorders and obesity.

Biography:

Mini Joseph is currently working as Assistant Professor in Food & Nutrition at Government College for Women, Trivandrum, Kerala. She is presently pursuing her Post-doctoral fellowship at the Department of Endocrinology, Diabetes & Metabolism, at Christian Medical College, Vellore, Tamil Nadu, India. She is recipient of Young Scientist Award from the Nutrition Society of India 2012. Her interests lie in community nutrition, energy expenditure research, sports nutrition and diabetes.

Abstract:

Introduction: Weightlifting is a power sport placing intense physical demands on the individual. The body composition of weightlifters is considerably different from that of other athletes.

Materials & Methods: This cross-sectional study was done on 30 selected elite professional male weightlifters in the age group of 18-28 years who were actively competing at national/international level from Vellore District in Tamil Nadu, India. The study was approved by the Institutional Review Board of Christian Medical College and Hospital, Vellore, Tamil Nadu, India. Their anthropometric measurements and body composition were assessed and analysed. All data were analysed using SPSS 16.0 for Windows.

Results & Discussions: The mean age of the participants was 21.5±2.87 years. The average duration of competitive weightlifting was 5.04±2.68 years. The mean height was 168.83±6.32 cm and mean weight was 75.95±14.73 kg. Their mean BMI indicated that they were overweight, (26.09±4.28) inspite of a low fat percentage of 15.2±5.3 9 (obtained by DXA [Hologic Delphi W (S/N 70471 DXA scanner)]. They had a high mean lean body mass of 60.9±9.2 kg indicating a well-developed musculature.

Conclusion: Thus we opine that BMI should be used as a sole tool to assess nutritional status but must be used in conjunction with the body composition to get the actual picture.

Biography:

The epidemiology of obesity, hypertension and other metabolic related cardiovascular diseases in children Early determinants, prevention and control of cardiovascular diseases early in children Developing and testing of clinical treatment protocols.Cross-sectional and cohort programs about cardiovascular risk factors and early intervention in Chinese children

Abstract:

The epidemiology of obesity, hypertension and other metabolic related cardiovascular diseases in children Early determinants, prevention and control of cardiovascular diseases early in children Developing and testing of clinical treatment protocols. Study Experience: Cross-sectional and cohort programs about cardiovascular risk factors and early intervention in Chinese children

Biography:

University Medical Faculty and Pediatric Endocrinology training from Hacettepe University Medical Faculty, Ankara. She is the director of Pediatric Endocrinology Department of her medical Faculty. She has published more than 45 papers in reputed journals.

Abstract:

Fibroblast growth factor(FGF-23) is a hormonal regulator of circulating phosphate and vitamin D levels,and it may also act as a 'hormone-like' factor involved in the glucose and fat metabolism. Some studies have showen that FGF-23 has a potential role in the development of insulin resistance and vascular dysfunction and adverse thickening of the vascular wall, however ,it remains controversial. Aim: It was to investigate the possible correlations between serum FGF-23 levels and body compositions,insulin resistance and carotid intima media thickness(cIMT) in obese adolescents Material and methods. The study included 46 obese adolescents (22 boys and 24 girls) and 46 non-obese healthy adolescents( 18 girls and 28 boys).The exclusion criteria were presence of disorders of calcium phosphor metabolism or any chronic diseases. HOMA-IR values were calculated by using fasting insulin and blood glucose values in all patients and controls. Plasma FGF-23 level was measured using ELISA, cIMT was evaluated ultrasonographically. Results. HOMA-IR , fasting insulin levels were significantly higher in obese group than controls, but FGF-23 and klotho levels were significantly lower in obese group(FGF-23: 310± 97pg/ml, Klotho:33.45 ± 10.9 pg/ml) when compared with controls( FGF-23:515 .71 ± 142 pg/ml , Klotho: 56 . 17 ± 22 pg/ml) . In this group, FGF-23 and Klotho were negatively correlated fasting insulin and HOMA-IR. cIMT values were incresead in obese group( 0.56 mm) than those of controls(0.41mm) and positively correlated with BMI , fasting insulin and HOMA-IR level, but not FGF-23 levels. Conclusion. These findings suggest that incresed insulin level may cause of lower FGF-23 and klotho levels in obese patients. Increased cMIT is more likely related to insulin resistance , but not FGF-23 in obese patient.

Biography:

Shuyin Mao completes

Abstract:

Obesity is increasing in prevalence in the United States and worldwide, In Taiwan men prevalence was 19.2% nearly South Korea 12 times that of Japan 8 times. in woman prevalence was 16.6% also South Korea and Japan 5 times. Health hazards associated with obesity in adults including type 2 diabetes, heart disease, stroke, certain cancers, osteoarthritis, liver disease, obstructive sleep apnea, and depression. cost of treating obesity and its complications in the United States is approximately 100 billion dollars per year. increased rate of death from all causes and from cardiovascular disease. Method: Case 56year old male patient past history of(1) DM with OADs and insulin control over 10years,102/5/21 C-peptid 3.97ng/dl(2)CAD,DVD s/p cardiac catheter(with drug eluting Stenting)(3)erythromatous gastritis and esophagitis regular PPI(4)old lacunar Infarction.BMI:38 visit GS with Bariatric surgical LSG(mechanisms: restriction:102/6/26)with Dietitian nutrition consultation and follow. Result: BW loss at post op 2 months 11kg. post op three months Bw loss:18kgblood glucose controlwellHbA1C:10.3(5/1)→8.7(7/10) →7.7(8/6) →6.4(103/4). AC sugar control :189mg/dl(5/1). →133 mg/dl(7/10) →113 mg/d (8/6) →103(103/4)Insulin injection:NPH: 20u→15u→10u. lipid profile:HDL:40mg/dl LDL:120mg/dl.UA:6.3mg/dl.Body fat :34.3—30and waistine 105cm hips:105cm. Conclusion For many study Bariatric surgical(Roux-en-Y gastric bypass) treatment DM Ghrelin is a peptide hormone secreted in the foregut (stomach and duodenum) that stimulates the early phase of meal consumption. in laparoscopic sleeve gastrectomy exaggerated response of peptide YY (PYY) may also contribute to the loss of appetite Hormones such as glucagon-like peptide-1 (GLP-1) and cholecystokinin (CCK), which are increased after RYGB, may promote an anorectic state. In this case use LSG and diet control and adequate excise successful weight control and treatment DM and metabolic syndrome. Key word: Moderate obesity、Bariatric surgical、 Laparoscopic sleeve gastrectomy、DM、Metabolic syndrome

Biography:

Sondos Harfil is a Lecturer at the College of Health Sciences and instructed several courses. She is serving as a member in several community associations and comittees. She has completed her MSc and higher diploma in Biology from University of Jordan and currently enrolled in PhD program at University Sains Malaysia, Biomedicine department. Her research interest is in the field of gut micorbiota and obesity.

Abstract:

Obesity is a growing epidemic in many countries. There’s a remarkable development in the investigation of obesity-induced insulin resistance. Low- grade inflammation is involved in the molecular mechanism of insulin resistance. Recently, the influence of changing gut microbiota has been investigated as contributing factor for obesity and metabolic aberrations. Obesity is associated with an altered gut microbiota in humans. The composition of the gut microbiota has been shown to differ in lean and obese humans and animals, and to change rapidly in response to dietary intervention. The gut microbiota may influence the development of obesity and type 2 diabetes which are characterized by low grade inflammation. These results support the emerging views that the gut microbiota contributes to metabolic disease by modulating host metabolism. Lipopolysaccharides (LPS) are released from the dead Gram-negative bacteria in the gut, and under conditions of gut damage can translocate into the circulation where it trigger an inflammatory response. LPS-binding protein (LBP) is another reactive biomarker formed in response to microbial translocation. LPS and LBP serum levels have been associated with obesity and with other cardiovascular and metabolic morbidities. There are growing evidences that the altered composition of the gut microbiota and the resulted endotoxemia are responsible for the rapid increase in obesity. The aim of the current review is to discuss the recent research findings that have focused on the involvement of gut microbiota and metabolic endotoxemia in human obesity, and the potential role of dietary intervention to restore the normal gut microbiota. The studies indicated that the normal composition of the gut microbiota is altered with high fat diet. There are many studies that correlated the high levels of endotoxicity to low grade inflammation and the emergence of metabolic disorders and obesity.

Biography:

Ying Li has completed her Nutrition and Food Hygiene PhD at the age of 36 years from Harbin Medical University and postdoctoral studies from department of pharmacology of Harbin Medical University. She is the principal investigator of seven research grants now . She has published more than 99 papers in reputed journals and has been serving as an editorial board member of repute

Abstract:

It is unclear why the prevalence prediabetes between diagnosed by oral glucose tolerance test (OGTT) and hemoglobin (A1c) criteria is substantially discordant. We aimed to evaluate the effects of obesity on the agreement between A1c and OGTT for diagnosing diabetes and prediabetes and identify the optimal A1c cut-off values in different BMI classifications. In a population-based cross-sectional study in Harbin, China, 4325 individuals aged 20-74 years without a prior diagnosed diabetes were involved in this study. The performance and optimal cut-off points of A1c were assessed by receiver operating characteristic curve. The contribution of body mass index (BMI) to A1c was analyzed by structural equational model (SEM).The agreement between A1c criteria and OGTT decreased with BMI gain (=0.359, 0.312, and 0.275 in normal weight, overweight, and obese population, respectively). The SEM results showed that BMI was significantly associated with A1c in normal glucose tolerance and prediabetes subjects, but not in diabetes subjects. At a specificity of 80% for prediabetes and 97.5% for diabetes, the optimal A1c cut-off points for prediabetes and diabetes were 5.6% and 6.4% in normal weight, 5.7% and 6.5% in overweight, and 6.0% and 6.5% in obese population. When the new A1c cut-off values were used, the agreement in obese subjects increased almost to the level in normal weight subjects.The poor agreement between A1c and OGTT criteria in obese population can be significantly improved through increasing A1c threshold for prediabetes.

Biography:

Samuel Chng studied psychology at James Cook University and is currently a final year PhD researcher in applied psychology to health at the University of Exeter Medical School. His research interests revolves around understanding the role of parental and environmental influences in behaviour development. His recent works include the evaluation the use of social-psychological actions theories for explaining health preventive behaviours.

Abstract:

Parents are one of the most salient sociocultural influence towards the development of disordered eating, such as restrained and affect-regulatory eating, and dieting behaviour. The active influence perspective suggests that this is due to the communication and interactions between parent and child. Findings from two studies that explored the role of parental influence on eating behaviours will be presented. The first study looked at how comments regarding body shape, weight, and eating behaviors by parents are related to the occurrence of body dissatisfaction and restrained and affect-regulatory eating in young adults in Singapore. Negative comments by mothers were found to consistently predict restrained and affect-regulatory eating for both sons and daughters. The second study explores the relationship between the appraisals of parental support and dieting attempts in adolescents in the UK. Postiive appraisals of parental support were not found to predict dieting attempts by girls but, interestingly, was found to predict a higher odds of dieting attempts by boys. Collectively, findings from both studies suggest that parents play an important role in the development of disordered eating but these relationships might vary cross-culturally. Future interventions of health and eating behaviours should consider the role parents can potentially play to improve the efficacy of treatment.

Biography:

Zahra Bahadoran is a senior researcher at the Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences (Islamic Republic of Iran). She holds a Master degree in Nutrition sciences and Diet therapy from the Tabriz University of Medical Sciences. She is Ph.D by research in the field of nutrition and endocrine diseases at the Shahid Beheshti University of Medical Sciences. She has published more than 60 papers in journals and conference proceedings, including more than 40 papers in journals indexed in the Web of Science and Medline such as Nutrition and Metabolism, Diabetes Research and Clinical Practice, Endocrinology and Metabolism, Nutrition, Journal of Diabetes and Metabolic Disorders, World Journal of Diabetes, Journal of Functional Foods, European Journal of Clinical Nutrition, Nutrition and Cancer, Asian Pacific Journal of Cancer Prevention, Journal of Medicinal Foods, J of Human Nutrition and Dietetics, Archive of Iranian Medicine, Iranian Journal of Public Health. She had several oral presentations on her research works in international congress including The 3rd International Congress on Lipid Metabolism & Atherosclerosis in Korea 2014, 17th International Conference on Food Science and Nutrition to be held in United Kingdom, 2015, 7th International Conference and Exhibition on Nutraceuticals and Functional Foods in Turkey 2014, 5th World Congress on Controversies to Consensus in Diabetes, Obesity and Hypertension in Turkey 2015.

Abstract:

Polyphenols are natural phytochemical compounds in plant-based foods, such as fruits, vegetables, whole grains, cereal, legumes, tea, coffee, wine and cocoa; more than 8000 polyphenolic compounds, including phenolic acids, flavonoids, stilbenes, lignans and polymeric lignans have been identified in whole plant foods. In recent years, there is growing evidence that polyphenols, due to their biological properties, may be unique nutraceuticals for prevention and treatment of obesity. Our aim here is to review the current evidences in relation to several potential efficacies of these bioactive components on various aspect of body weight control. Based on several in vitro, animal models and some human studies, dietary plant polyphenols and polyphenol-rich products modulate carbohydrate and lipid metabolism, glycemic and insulin response, improve adipose tissue metabolism, and alleviate oxidative stress and stress-sensitive signaling pathways and inflammatory processes, which are known as important underlying mechanisms in development of overweight and obesity. Moreover, dietary polyphenols have potential to reduce preadipocytes proliferation and differentiation and stimulate lypolysis and fatty acid β-oxidation. Some polyphenol could also modulate principle genes involved in adipocytes metabolism. In conclusion, plant polyphenols including phenolic acids, flavonoids, stilbenes and lignans have been proposed as effective supplements for management of overweight and obesity. Use of polyphenol-rich foods should also be considered as another important strategy in dietary planning of overweight and obese subjects.

Biography:

Yimin Zhu has completed his PhD in 2004 from Zhejiang University School of Medicine. He is the Professor and Vice-director of the Department of Epidemiology and Biostatistics, School of Public Health, Zhejiang Universty. His major scientific interest include envoronmental risk and genetic susceptiblity in complex diseases. He has published more than 120 scientific papers

Abstract:

Background: Both genetic and environmental factors are attributable to the incidence of obesity. Recent genome-wide association studies (GWAS) in European population have identified multiple single nucleotide polymorphisms (SNPs) related with obesity. Little is known about the effects of these loci in non-Caucasian populations and gene-lifestyle interactions. This study aimed to examine the associations of 20 candidate SNPs with obesity, and related metabolic traits among Chinese Han children and adolescents, and assessed the interaction effects with dietary behaviors.

Materials & Methods: A population based case-control study was conducted among 853 obese school-age children and 2124 controls in China. All candidate SNPs were genotyped using Sequenom Mass ARRAY iPLEX platform.

Results: After adjusting for age, sex and multiple testing, five SNPs (MC4R rs17782313, SEC16B rs543874, MAP2K5 rs2241423, KCTD15 rs11084753 and FTO rs9939609) were significantly associated with obesity (P: 1.91e-5, 0.009, 0.018, 0.012, 1.39e-4, respectively), with the odd ratios ranging from 1.22 to 2.40. Genetic risk score (GRS), calculated with the sum of the risk alleles among the associated five SNPs, showed a positive association with obesity (P value for trend: 8.50e-15). Moreover, the rs9939609 were found to be significantly associated with food preference (P: 0.005). The rs17782313 and rs11084753 were associated with salt preferences (all the P less than 0.05). Multiplicative interaction was found between rs543874 and salt preference on the risk of obesity, and additive interactions between rs17782313, rs11084753 and salt preference were exhibited.

Conclusions: Our findings indicate that genetic susceptibility plays an important role in obesity in Chinese Han children and adolescents.

Biography:

Yimin Zhu has completed his PhD in 2004 from Zhejiang University School of Medicine. He is the professor and vice director of Department of Epidemiology and Biostatistics, School of Public Health, Zhejiang Universty. His major scientific interest include envoronmental risk and genetic susceptiblity in complex diseases. He has published more than 120 scientific papers.

Abstract:

Background: Both genetic and environmental factors are attributable to the incidence of obesity. Recent genome-wide association studies (GWAS) in European population have identifie multiple single nucleotide polymorphisms (SNPs) related with obesity. Little is known about the effects of these loci in non-Caucasian populations and gene-lifestyle interactions. This study aimed to examine the associations of twenty candidate SNPs with obesity, and related metabolic traits among Chinese Han children and adolescents, and assessed the interaction effects with dietary behaviors. Materials and Methods: A population based case-control study was conducted among 853 obese school-age children and 2124 controls in China. All candidate SNPs were genotyped using Sequenom MassARRAY iPLEX platform. Results: After adjusting for age, sex and multiple testing, five SNPs (MC4R rs17782313, SEC16B rs543874, MAP2K5 rs2241423, KCTD15 rs11084753 and FTO rs9939609) were significantly associated with obesity (P: 1.91e-5, 0.009, 0.018, 0.012, 1.39e-4, respectively), with the odd ratios ranging from 1.22 to 2.40. Genetic risk score (GRS), calculated with the sum of the risk alleles among the associated five SNPs, showed a positive association with obesity (P value for trend: 8.50e-15). Moreover, the rs9939609 were found to be significantly associated with food preference (P: 0.005). The rs17782313 and rs11084753 were associated with salt preferences (all the P less than 0.05). Multiplicative interaction was found between rs543874 and salt preference on the risk of obesity, and additive interactions between rs17782313, rs11084753 and salt preference were exhibited. Conclusions: Our findings indicate that genetic susceptibility plays an important role in obesity in Chinese Han children and adolescents.

Biography:

Associate Professor Dr Foong Ming Moy is from the Epidemiology & Biostatistics Unit, Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. She teaches Research Methodology, Clinical Epidemiology & Evidence-Based Medicine to both undergraduate and postgraduate candidates. Her research interest includes obesity and cardiometabolic risks, prevention of non-communicable diseases, workplace wellness and nutritional epidemiology. Dr Moy is active in research and has published extensively in both local and international journals. Dr Moy serves as an editorial board member of the Nutrition Journal of Malaysia.

Abstract:

Objectives: To determine the prevalence of normal weight obesity among multi-ethnic women in Peninsular Malaysia and examine its associations with cardiometabolic risks and lifestyle behaviours. Methods: This was a cross-sectional study involving women recruited via multi-stage sampling from six states in Malaysia. Anthropometric and body composition analysis were performed. Normal weight obese (NWO) was defined as normal body mass index for Asians and the highest tertile of % body fat (BF). Biochemical measurements included fasting lipid and blood glucose levels. Metabolic syndrome was diagnosed based on the Harmonization criteria. Participants completed self-reported questionnaires that included physical activity, smoking, alcohol consumption, fruit and vegetable intake and sleep duration. Main outcome measure: Body mass index, %BF, cardiometabolic risk factors, lifestyle behaviours. Results: A total of 6854 women were recruited and the prevalence of NWO was 19.8% (95% CI: 17.3–22.5). NWO was more prevalent among the Indians and older women. NWO women had higher odds for abdominal obesity (OR: 2.64, 95% CI: 1.73–4.04), hypertriglyceridemia (2.51, 1.47–4.29) and hypertension (1.63, 1.15–2.31) compared to women with lower % body fat after adjusted for age and ethnicity. The prevalence of metabolic syndrome among NWO women was 5.4% (95% CI: 3.0–9.8). None of the lifestyle behaviours were significantly associated with NWO. Conclusions: Women with NWO had cardiometabolic abnormalities including abdominal obesity, dyslipidaemia and increased blood pressure.

Biography:

Associate Professor Dr Foong Ming Moy is from the Epidemiology & Biostatistics Unit, Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. She teaches Research Methodology, Clinical Epidemiology & Evidence-Based Medicine to both undergraduate and postgraduate candidates. Her research interest includes obesity and cardiometabolic risks, prevention of non-communicable diseases, workplace wellness and nutritional epidemiology. Dr Moy is active in research and has published extensively in both local and international journals. Dr Moy serves as an editorial board member of the Nutrition Journal of Malaysia.

Abstract:

Objectives: To determine the prevalence of normal weight obesity among multi-ethnic women in Peninsular Malaysia and examine its associations with cardiometabolic risks and lifestyle behaviours. Methods: This was a cross-sectional study involving women recruited via multi-stage sampling from six states in Malaysia. Anthropometric and body composition analysis were performed. Normal weight obese (NWO) was defined as normal body mass index for Asians and the highest tertile of % body fat (BF). Biochemical measurements included fasting lipid and blood glucose levels. Metabolic syndrome was diagnosed based on the Harmonization criteria. Participants completed self-reported questionnaires that included physical activity, smoking, alcohol consumption, fruit and vegetable intake and sleep duration. Main outcome measure: Body mass index, %BF, cardiometabolic risk factors, lifestyle behaviours. Results: A total of 6854 women were recruited and the prevalence of NWO was 19.8% (95% CI: 17.3–22.5). NWO was more prevalent among the Indians and older women. NWO women had higher odds for abdominal obesity (OR: 2.64, 95% CI: 1.73–4.04), hypertriglyceridemia (2.51, 1.47–4.29) and hypertension (1.63, 1.15–2.31) compared to women with lower % body fat after adjusted for age and ethnicity. The prevalence of metabolic syndrome among NWO women was 5.4% (95% CI: 3.0–9.8). None of the lifestyle behaviours were significantly associated with NWO. Conclusions: Women with NWO had cardiometabolic abnormalities including abdominal obesity, dyslipidaemia and increased blood pressure.

Biography:

Mona Hashim has completed her M Sc in Nutrition and Dietetics from the American University of Beirut, Beirut Lebanon nad currently a PhD candidate at Universiti Sains Malysia, Malysia. She is a lecturer in Department of Clinical Nutrition & Dietetics, College of Health Sciences, University of Sharjah, United Arab Emirates. She has participated as a speaker in many local conferences in topics related to school children dietary patterns and childhood obesity, and published work of realted domain. Besides, she organised professional dietetics workshops. She is a member of the Academy of Nutrition and Dietetic (AND) and “Association for Nutrition and Food Sciences (LANFS)”, Lebanon.

Abstract:

Human milk is a complex active fluid that provides the optimal balanced nutrition for infants. In addition, non-nutritional and critical bioactive components have been detected in human milk such as anti-inflammatory mediators, as well as appetite-regulating hormones and growth factors. Recent studies focused on the possible role of breast feeding in the prevention of obesity with subequent decrease risk of diabetes mellitus among adults. Breast adipose tissue was found to be a source of adipokines, such as adiponectin, leptin and gherlin that are transported via breast milk to infants. Adiponectin, which is known for its insulin-sensitizing, anti-atherogenic, fat-burning and anti-inflammatory properties was detected in the serum of lactating mothers and breast fed infants more than the formula fed. Other adipocyte-derived hormones; leptin and ghrelin are produced and secreted by mammary epithelial cells in milk fat globules. A positive correlation has also been reported between human milk leptin levels and infant plasma leptin. Leptin and ghrelin have been shown to regulate energy homeostasis by relaying information about the body’s energy and nutrient stores from the periphery to the brain, thus decreases food intake and reflects the amount of body fat. Consequently, a possible role of adipokines as a satiety signal with a long-term effect on energy balance and body weight can be suggested. Human milk continues to be recommended as the preferred choice of feeding for all infants by national and international health organizations. The promotion of breast feeding can be a potential component of the primary health care efforts considering its role in early life determinants of later-onset obesity, non-communicable diseases and for the timely preventive measures that will improve overall health status of population.

Biography:

Rui Azevedo Guerreiro has graduated in Medicine from NOVA Medical School in Lisbon, Portugal and is currently attending the Clinical Scholars Research Training Program from Harvard Medical School. Rui worked in the Bariatric and Metabolic Diseases Surgical Unit of the Central Lisbon Hospital Centre where, together with Rui Ribeiro, president of the Portuguese Society of Bariatric Surgery and Metabolic Diseases, developed his work on “Ophthalmic complications of Bariatric Surgery”.

Abstract:

Obesity is increasing vastly in the world, and the number of bariatric surgeries being performed is also increasing. Patients being submitted to bariatric surgeries, especially malabsorptive procedures, have an increased risk of developing nutrient deficiencies, which can culminate in symptomatic hypovitaminosis, if supplementation is not done correctly. The eye and the optic system need an adequate level of several vitamins and minerals to perform properly, especially vitamin A, and my presentation wants to cover the main nutrients involved, the possible ophthalmic complications that can arise by their deficiency, and the management of those complications.

Biography:

Jianfang Li has completed his MD at the age of 27 years from Wenzhou Medical University. He has published more than 6 papers in reputed journals and has been serving as an editorial board member of repute.

Abstract:

Abstract Our aim was to compare laparoscopic Roux-enY gastric bypass (LRYGB) and laparoscopic sleeve gastrectomy(LSG) for treating morbid obesity and its related comorbidities. An electronic literature search was performed from inception to May 2015 and a total of 18,455 patients, enrolled in 62 recent studies, were included in this meta-analysis. Patients receiving LRYGB had a significantly higher percentage of excess weight loss and better resolution of hypertension, dyslipidemia, gastroesophageal reflux disease, and arthritis compared with those receiving LSG. LRYGB and LSG showed similar effects on type 2 diabetes mellitus and sleep apnea.