Aysehan Akinci
Ä°nonu University, Turkey
Title: The association of FGF-23 levels with insulin resistance and carotid intima thickness in obese adolescents
Biography
Biography: Aysehan Akinci
Abstract
Fibroblast growth factor(FGF-23) is a hormonal regulator of circulating phosphate and vitamin D levels,and it may also act as a 'hormone-like' factor involved in the glucose and fat metabolism. Some studies have showen that FGF-23 has a potential role in the development of insulin resistance and vascular dysfunction and adverse thickening of the vascular wall, however ,it remains controversial. Aim: It was to investigate the possible correlations between serum FGF-23 levels and body compositions,insulin resistance and carotid intima media thickness(cIMT) in obese adolescents Material and methods. The study included 46 obese adolescents (22 boys and 24 girls) and 46 non-obese healthy adolescents( 18 girls and 28 boys).The exclusion criteria were presence of disorders of calcium phosphor metabolism or any chronic diseases. HOMA-IR values were calculated by using fasting insulin and blood glucose values in all patients and controls. Plasma FGF-23 level was measured using ELISA, cIMT was evaluated ultrasonographically. Results. HOMA-IR , fasting insulin levels were significantly higher in obese group than controls, but FGF-23 and klotho levels were significantly lower in obese group(FGF-23: 310± 97pg/ml, Klotho:33.45 ± 10.9 pg/ml) when compared with controls( FGF-23:515 .71 ± 142 pg/ml , Klotho: 56 . 17 ± 22 pg/ml) . In this group, FGF-23 and Klotho were negatively correlated fasting insulin and HOMA-IR. cIMT values were incresead in obese group( 0.56 mm) than those of controls(0.41mm) and positively correlated with BMI , fasting insulin and HOMA-IR level, but not FGF-23 levels. Conclusion. These findings suggest that incresed insulin level may cause of lower FGF-23 and klotho levels in obese patients. Increased cMIT is more likely related to insulin resistance , but not FGF-23 in obese patient.