Weimin Yang,
First Affiliated Hospital of Zhengzhou University, China
Title: Intracerebral haemorrhage growth is influenced by anticoagulation intensity
Biography
Biography: Weimin Yang,
Abstract
Background: Intracerebral hemorrhage (ICH) is a significant contributor to global health-related morbidity and mortality. Due
to improved recognition and treatment of atrial fibrillation by antithrombotics, there is an increase in proportion of ICH caused
by warfarin and novel oral anticoagulants. However, the relationship between anticoagulation intensity and hematoma expansion
remains unclear. We aimed to investigate the effects of INR on hematoma expansion post ICH.
Methods: We conducted a retrospective study of all patients hospitalized for ICH at a single institution from January 1, 2008 and
August 1, 2014. Hematoma volumes on initial CT scans and repeat CT scans were analyzed by the AxBxC/2 method. Univariate
analysis was used to compare baseline characteristics and median regression analysis was performed to estimate the effects of INR
and hematoma volume changes.
Results: We included 224 consecutive ICH patients. Median age (IQR) was 68.5 years (17.0), 60.3% were male, median presentation
Glasgow Coma Scale (GCS) (IQR) was 14.0 (4.0), median volume (IQR) of the first CT was 11.7ml (25.6), median INR (IQR) was
1.1 (0.2). We showed that INR and time lapsed between first CT and second CT were independent risk factors to hematoma volume
change, adjusting for baseline hematoma volume and time. For each 1.0 increase in INR was associated with hematoma volume
increased by 2.4ml (p = 0.015).
Conclusions: We showed that high INR was associated with hematoma growth post ICH. However, the effects of reversal
anticoagulation