Neurology and Neuro Surgery

Immune cells and molecules in tumor microenvironment are crucial in tumorigenesis. Inflammation is known as one of hallmarks

of cancer and is considered as an protumorigenic factor. Glioma tumor microenvironment glioma still needs deeper insight into its

immunological characteristics. Both local and systemic chronic low grade inflammatory response are operative for correlation with

gliomas grading and their prognosis. Complex network of immune signals and pathways is in intricate background of most of cancer

hallmarks. This concept is an intersection of three huge research fields: immunology, oncology and neurology. Cancer immunology

has a perspective in complex approach to diagnosis of gliomas. There is an appealing importance of establishing immune molecules

in gliomas. TREM-1 (Triggering receptor expressed on myelocytes) is an inflammation amplifier, hovewer its role in glioma remains

still unclear. The aim of our study is to establish the expression of TREM-1 in glioma tissues and to correlate it with staging, grading

and other laboratory parameters. Establishing of TREM-1 expression could have a promissing role in pathophysiology of gliomas.

Our preliminary results show densely infiltrating TREM-1+ immune cells in tumor tissue. At signal pathways level, inflammation is

interconnect with molecules related to hypoxia. Cross-talk of inflammation and hypoxia becomes more obvious in glioma as well.

Consideration of relations dynamics is also necessary. But, deep understanding of their signal network in glioma tumorigenesis

is challenging. Our aim is to provide critical view on our pivotal results in framework of data from literature and discuss their

significance for deep understanding of glioma tumorigenesis.