Jianhua Zhang,
Peking University First Hospital, China
Title: Application of 18F-FDG PET/CT in detection of transformation of small lymphocytic lymphoma/chronic lymphocytic leukemia
Biography
Biography: Jianhua Zhang,
Abstract
Richter’s transformation (RT, Richter’s syndrome) was first described by Maurice Richter as the development of an aggressive
large-cell lymphoma in the setting of underlying small lymphocytic lymphoma /chronic lymphocytic leukemia (SLL/CLL).
We try to investigate the role of in detection of RT of SLL/CLL. Twelve patients with SLL/CLL underwent 18F-FDG PET/CT
between Jul 2010 and Nov 2015 were retrospectively analyzed. FDG avid lesions with a maximum standardized uptake value
(SUVmax) of greater than 5 were considered highly suggestive of RT. The diagnosis of RT was based on the histopathological
examination. All patients (8 males and 4 females) had the history of SLL/CLL ranged from 2 years to 11 years. Four patients
underwent RT to diffuse large B-cell lymphoma, PET/CT detected sites of increased FDG uptake with SUVmax ＞5 in 3
patients(3/4, 75%), 1 patient has false-negative PET/CT findings. No patient had false-positive PET/CT findings and PET/CT
correctly excluded RT in the other 8 patients. The overall sensitivity, specificity and accuracy of PET/CT for RT of SLL/CLL
were 75%, 100% and 91.6%, respectively. According to the preliminary data, 18F-FDG PET/CT has high accuracy for detection
of RT of SLL/CLL. PET/CT can exclude the diagnosis of RT with a high degree of confidence in patients with SLL/CLL.