Liu Hong
Shandong University of Technology, China
Title: Insights into the Evolutionary History of an Emerging Virus：Banna virus
Biography
Biography: Liu Hong
Abstract
Banna virus (BAV) was initially isolated from patients with encephalitis and fever in Yunnan Province of China in 1987. Since then, BAV isolates have been obtained from pigs, cattle and kinds of blood suking insects in China, Indonesia and Vietnam, which were mainly located in tropics and sub-tropic zones. In 2013, BAV like viruses have been reported isolated in Hungary, showing that this kind of viruses have been extends from tropical and sub-tropic zones of Southeast Asia to North temperate regions of Europe. BAVs has been considered as an emerging pathogen. However, until now, no systematic evolutinary analysis of BAVs have been reported. In this study, We used genome sequences of segment 12 of BAVs isolated worldwide from 1987-2012 to investigate evolutionary and epidemiologic dynamics. Phylogeographic approach estimated BAVs was originated in the Indonesia region and then rapidly spreaded to Southeast Asia and Europe within just about 30 years. The Bayesian phylogenetic analysis of BAVs reveals the time to most recent common ancestor and initial divergence of BAVs was at about the beginning of 20th century. Population dynamics analysis indicated that the genetic diversity of BAVs declined in the late 1980, suggesting that the virus of BAV was suffering from bottle-necked event. These results and their interpretation provide new insights into our understanding of BAV evolution and dispersal and highlight its potential for introduction into new areas.