12^th Global Dermatologists Congress August 30-31, 2017 London, UK

Biography:

Zhiqi Hu, PhD., MD., Professor, Archiater, Director of the department of plastic and aesthetic surgery, NanFang hospital, Southern Medical University, Guangdong, China. He obtained the doctorate in plastic surgery of Sun yat-sen Medical University in 1993. He was studying in Japan for one year in 2003. He is devoted to the basic and clinical research of hair medicine. He has made a lot of contribution in hair follicle transplantation and hair follicle regeneration research and have published more than 20 papers about hair medicine in foreign magazines registered by the SCI. At present, he is the vice president of cosmetic and plastic surgeon branch, Chinese Medical Doctor Association. Director of the hair plastic professional committee, cosmetic and clastic surgeon branch, Chinese Medical Doctor Association. Director of the plastic surgeon branch, Medical Doctor Association of Guangdong province.

Abstract:

Biography:

Yong Miao, PhD., MD., Attending physician of the department of plastic and aesthetic surgery, NanFang hospital, Southern Medical University, Guangdong, China. He is devoted to the basic and clinical research of hair medicine since 2007. As the first author, he has published 17 research papers about hair medicine, among which, 7 had been published in foreign magazines registered by the SCI, 10 had been published in the domestic medicine core journal magazine in China.

At present, he is the secretary and member of the hair plastic professional committee, cosmetic and clastic surgeon branch, Chinese Medical Doctor Association

Abstract:

Biography:

Maryam Borumand is an advanced Aesthetics Practitioner who has specialization in Non-surgical treatments. She holds a Bachelor of Science degree in Biomedical Science from Kings’ College London, a PhD in Biochemistry from University of East Anglia, and a Post-graduate Diploma in Physician Associate Studies from University of Birmingham. She is a member of the Royal College of Physicians and is part of the Editorial Board for the Journal of Procedural Dermatology. Since 2010, she worked in General Practice for over an year and then at a number of clinical research organizations, before setting up her aesthetics business, YouGlo, UK

Abstract:

Since its establishment in 2004, GENOSS has put enormous efforts to become the world’s leading medical device company. The primary mission set forth by GENOSS is to focus on delivering treatment solutions and promoting the well-being of its consumers and patients. GENOSS strives to prepare for a big leap forward into the endless competition of the world’s biotechnology market through its technical innovation. With a considerable portion of sales being spent on Research & Development, and supported by a group of immensely experienced and talented R&D professionals, GENOSS has demonstrated a strong commitment to R&D and to manufacture products with world-beating quality. In addition, GENOSS strictly fulfills and complies with the international quality regulations, including KGMP, ISO 13485 and ISO 9001. Furthermore, the CE mark and the FDA approval on each product confirm its conformity with all of the legal requirements. Mona Lisa dermal filler is new innovative filler with the following properties: 1. Volume effect and retention - the uniform sized hyaluronic acid particles with optimal viscoelasticity can maintain a long-lasting volume. 2. Safe to use on patients – Mona Lisa is safe to use on patients due to low level of endotoxin and essentially no BDDE residue. 3. Easy procedural operation - the ergonomically-designed rod and grip allow the even distribution of pressure during injection to enable an accurate and safe treatment for both the clinician and the patient. 4. Highly pure hyaluronic acid-GENOSS implements a strict quality control system through direct involvement in the entire production process from the base material of hyaluronic acid to the final product. 5. Global standard quality control - To guarantee the quality of Mona Lisa, GENOSS strictly fulfills and complies with the international quality regulations, including KGMP, ISO 13485 and ISO 9001

Biography:

Evelina Buinauskaite graduated from Kaunas University of Medicine in 2005 and has been excelling in her field. In 2009, she successfully obtained a dermatovenereologist qualification followed by a PhD in biomedicine in 2014. Her international based learning resulted in her co-writing numerous national and international presentations, research, articles and books. She is an EADV Alumni Club member, board member of the BADV and a proud member of various representative organisations. The experience gained during her time volunteering in the United Republic of Tanzania brought her a recognition for Excellent Case presentation in 2016 from Austria. Her main fields of interest are nonmelanoma skin cancer and research.

Abstract:

Human skin color is variable around the world and ranges from almost black to nearly colorless. Studies have revealed that the differences between the skin of whites and blacks extend well beyond the degree of melanin pigmentation. For example, the structural differences include the skin thickness, water content and lipids. Darker skins may have an inherent tendency to show particular reaction patterns that are different from those seen in white skin. Taking one with another, lesions on different skin hues may also look differently, eg. red or brown lesions in white skin may appear black or purple in pigmented skin. If you mainly studied lesions on the white skin, diagnosing lesions on the dark skin can be of a challenge.

Biography:

Uzma Rajar is currently working as an Associate Professor in the Section of Dermatology at Isra University Hospital Hyderabad. She holds a MBBS degree from Liaquat University of Medical & Health Science, a Liaquat University of Medical & Health Science, D.D.Sc in Dermatology from University of Wales (U.K), and a M.Sc in Dermatology from Cardiff University. She has done her internship in the Dermatology Department at LUMHS Hospital

Abstract:

Background: Skin hyperpigmentation lesions are of multiple types and include; melasma, solar lentigines, nevi, macules, café-au-lait spots, and ephelides (freckles), etc. Post inflammatory hyperpigmentation also occurs in conditions such as surgical trauma, physical trauma, acne, atopic dermatitis, contact dermatitis, lichen planus, psoriasis, drug eruptions, and etc. During clinical approach to skin hyperpigmentation, one must considers about an increase in melanocytes, increase in melanin pigment production, and/or some other pigment, endogenous or exogenous, which is being deposited in skin.

Aim: Aim of this study is to evaluate clinical presentation of melasma with other hyperpigmentory disorders of skin and; to compare histopathological features of melasma with other hyperpigmentory disorders of skin.

Subjects & Methods: A Prospective, observational study was conducted at the outpatient department of Dermatology Department Isra University Hospital Hyderabad from July 2014 - December 2014. A sample of 87 subjects was selected according to non-probability simple random sampling as per inclusion and exclusion criteria including 43 melasma and 44 other skin hyperpigmentory disorders. Detailed clinical examination was performed prior to the biopsy to mark the biopsy site. Aspirin and non-steroidal anti-inflammatory drugs were stopped at least 5 days before biopsy. A single strand or in some cases >one punch biopsies of skin were obtained and sent for histopathological evaluation. All the clinical and histological data were entered in proforma designed for the study. Collected data was analyzed on SPSS version 21.0. (IBM, corporation, USA) P-value of significance was taken at 0.05.

Results: Mean±SD age of study subjects was noted as 39.51± 9.32 and 39.50± 9.21 years in melasma and other skin hyperpigmentory disorders respectively. Female population predominated in the present study. 37 (42.5%) were male and 49 (56.3%) were female. Common presenting features were the hyperpigmentation, skin peeling, itching, erythema and telangiectasia. Hyperpigmentaion, itching and erythema were the common presenting complaints. Telangiectasia was noted in 3 male in melasma and 1 female in other skin hyperpigmentory disorders. Of 43 melasma patients (Group A), the hyperkeratosis was noted in 3 male patients only (X²=48, p=0.0001). Parakeratosis and acanthosis were noted in female melasma patients. While hyperkeratosis, parakeratosis and acanthosis were noted in female patients of other hyperpigmentory disorders (Group B) (X²=38, p=0.0001).

Conclusion: Common presenting features were the hyperpigmentation, skin peeling, itching, erythema and telangiectasia in melasma and other hyperpigmentory lesions. Hyperpigmentaion, itching and erythema were the common presenting complaints. Telangiectasia was noted also. Histopathological findings suggested no major differences in the melasma and other hyperpigmentory disorders

Biography:

Fadel M Ali, Professor of Radiation and Medical Biophysics Cairo University, BSC Physics, Cairo University 1957. PhD, Nuclear Physics 1961 Hungarian Academy of science, Budapest. He has 232 published articles in the fields of Nuclear Physics, Radiation dosimetry and Biophysics. His main scientific interest in the past 30 years is the control of cellular functions by ELF-EM waves at resonance frequency with the target physiological function. In 1998 he suggested the Metabolic Biomagnetic Resonance Model (MBMRM) to explain the interaction mechanisms of EM waves with Biological systems (International Conference for theoretical Biophysics Moscow 1998). He suggested new spectroscopy field “Metabolic Spectroscopy” to explain and control interaction mechanisms of ELF-EM waves with alive systems (9th EMF International conference on Bioelectromagnetics, Garni, Armenia 2016).

Abstract:

Skin infections represent a significant burden of infection diseases. Complicated skin infections characteristically involve deeper skin structures or coexist in patients with immune suppression, infected burns, ulcer wounds and diabetic foot infection. These infections are likely to be poly- microbial. There is a world midst of an immerging crisis of antibiotic resistance for microbial pathogens. Therefore it seems necessary to find out other alternative safe and efficient methods for the treatment microbial infection diseases.

In this work a new noninvasive technique, using extremely low frequency (ELF) square electric pulses for the treatment of bacterial infected skin diseases. The frequency and duration time of exposure of these pulses were chosen depending on the resonance inhibiting frequency for the growth of the infecting bacteria according to previous reported in vitro and in vivo studies. The trial was expanded to diabetic foot treatment through clinical trial project with the Egyptian Ministry of Health and supported by the Egyptian Ministry of Defense. The trial was done at Almaza Military Hospital in Cairo , Egypt.

In this method the subject is exposed to the ELF-EM field of strength 2.0 V/CM generated between two parallel copper plate electrodes connected to the pulse generator. The distance between the two electrodes is 150 cm. The exposure time and number of sits depend on the type/s of the infecting micro organism and the treated case condition. The clinical trial covered 100 patients.

Clinical investigations indicated no growth for bacteria and accelerates healing of the infected area after exposure for all ELF-EM treated cases.

Biography:

Mostafa Elnakib, MD Microbiology and immunology, consultant of infection prevention control. Member of clinical trial team for assessment of the Non-Invasive (ELF-EM) waves technique, for accelerating healing of infected burns, to create new pathways for improving healthcare after years of working in research. This approach is important to change the policy of bacterial skin infection in different lesions and make a great benefit to all health care workers by this new way of treatment to alleviate the suffering of patients and give them hope in rapidly healing.

Abstract:

The skin, one of the largest organs in the body, performs numerous vital functions, provides primary protection against infection by acting as a physical barrier. When this barrier is damaged, pathogens can directly infiltrate the body, resulting in infection. The numerous pathogens that infect the wound either Gram positive, Gram negative or Fungi. These pathogens are notable for their increasing resistance to a broad array of antimicrobial agents. The Aim of this study was to demonstrate a new method for the control of bacterial growth, through ELF-EM pulses at resonance frequency with the bioelectric signals generated from the microbe during cell division. Methodology & Theoretical Orientation: Patients will be screened for fulfillment of the inclusion and exclusion criteria. Medical history, physical examination, Local and systemic signs and symptoms of infection, wound description and vital signs were evaluated. Bacteriological assessment as a swab was collected from infected site(s) before and after each session, for culture and identification of the causative pathogen, without the patient received antibiotic regimen. Patient was exposed to one session every other day till complete eradication of causative pathogen of the infection with an average of four exposure sessions, duration of each session depends on the causative organisms. Findings: it was noticed and reported that the exposure of the infected burns, not only accelerating healing but also, accelerated bio-compatibility in cases of grafting.   Conclusions: the resonance frequency of ELF-EM waves that inhibit bacterial growth is a promising method for the treatment of infected burn.

Biography:

Mohamed Salaheldin has specialized in internal medicine after being involved in research work related to neuro-vascular, dermatologic and pathological complications of endocrinal disease, He is also interested in contemporary Bio-Physical techniques adding new input in research work related to infection control during his experience in Egyptian military hospitals and research institutes to participate as a member in the team of the clinical trial to assess the role of ELF-EM waves in controlling skin infection and wound infection in type 2 Diabetes patients

Abstract:

Sensory neuropathy, atherosclerotic vascular disease, and hyperglycemia all predispose patients with diabetes to skin and soft tissue infections. These can affect any skin surface but most commonly involve the feet, these infections span the spectrum from simple, superficial cellulitis to chronic osteomyelitis. The Aim of this study was to demonstrate a new method for the control of bacterial growth, through the interference with the bioelectric signals generated from the microbe during cell division by extremely low frequency electromagnetic waves (ELF-EMW-ELF-EM) at resonance frequency. Methodology & Theoretical Orientation: Patients will be screened for fulfillment of the inclusion and exclusion criteria. Medical history, physical examination, Local and systemic signs and symptoms of infection, wound description and vital signs were evaluated. Bacteriological assessment as a swab was collected from infected site before and after each session, for culture and identification of the causative pathogen, without the patient received antibiotic regimen. Patient was exposed to one session every other day till complete eradication of causative pathogen of the infection with maximum exposure 12 sessions, duration of each session depends on the causative organisms. Findings: the bacteriological cultures revealed no growth for microorganisms by the end of sessions.   Conclusions: the resonance frequency of ELF-EM waves that inhibit bacterial growth is a promising method for the treatment of skin infection in diabetic patients. Significance and impact of the study: This new technique for treatment of bacterial infections is proved to be fast, economic, non-invasive applicable technique in treatment of type2 DM

Biography:

Mostafa Abohatab is a fellow of the Royal College of Surgeons in Dublin, As he spent years in research related to surgical complications of skin grafting, control of infected surgical wounds; it is a good chance to participate as a member in the team of the clinical trial to assess the role of ELF-EM waves in accelerating healing in infected and non-healing surgical wounds

Abstract:

Healing is a complex cascade of cellular events that generates resurfacing, reconstitution, and restoration of the tensile strength of injured skin. Factors that contribute to non-healing chronic wounds are diabetes, venous or arterial disease, infection, and metabolic deficiencies of old age. The wound healing process is not only complex but also fragile. Wound care encourages and speeds wound healing via cleaning and protection from re-injury or infection. Adequate control of blood glucose levels plays a crucial role in diabetic healing wound. The Aim of this study was to demonstrate a new method for enhancement wound healing process, through extremely low frequency electromagnetic waves (ELF-EMW-ELF-EM) at 0.7 HZ. Methodology & Theoretical Orientation: Patients will be screened for fulfillment of the inclusion and exclusion criteria. Medical history, physical examination, Local and systemic signs and symptoms of infection, wound (infected/ clean) description and vital signs were evaluated. Bacteriological assessment as a swab was collected from infected site(s) before and after each session, for culture and identification of the causative pathogen, without the patient received antibiotic regimen. Patient was exposed to one session every other day till complete eradication of causative pathogen of the infection. Findings: in infected wound, the bacteriological cultures revealed no growth for microorganisms by the end of sessions, and then healing process monitoring was measured as well as in a clean wound.   Conclusions: the resonance frequency of ELF-EM waves that inhibit bacterial growth will be promising method for the wound healing process. Significance of the study: This new non-invasive technique for treatment of bacterial infections and wound healing is of considerable interest for the use in medical and chronic non-healing wounds.

Biography:

Hui-Min David Wang, a Full Professor at Graduate Institute of Biomedical Engineering (National Chung Hsing University), graduated from the Department of Chemical Engineering, National Cheng Kung University, Tainan, Taiwan. In 2014, he got Ta-You Wu Memorial Award which is the highest price to young scientist of Ministry of Science and Technology (MOST) in TW. In 2015, he got Young Scholars Biotechnology Invention Award which is the highest price to young scientist of Taiwan Society of Biochemistry and Molecular Biology (TSBMB) in TW. In 2016, he got the Precious Stone Award in TW

Abstract:

This study assessed the use of astaxanthin as an anticancer agent for increasing inhibition to melanomacells (A375 and A2058). Wound healing and invasion assays presented that astaxanthin treatmentreduced melanoma cell migration in a dose-dependent manner. The effects on melanoma cell migrationwere conferred via suppressed expressionsof matrix metalloproteinases 1, 2 and 9. Dichlorofluoresceindiacetate assay further showed that astaxanthin treatment reduced production of cellular reactiveoxygen species. Cellular proliferation assay revealed potent dose-dependent inhibiting effects onmelanoma cells. One-dimensional flow cytometric analysis demonstrated that astaxanthin induced cellcycle arrest in G1 phase. Mechanisms of apoptosis were verified by double fluorescence staining withannexin V-fluorescein isothiocyanate and propidium iodide. The antitumor effects of astaxanthin significantlydecreased tumor size in a xenograft model. In summary, the experimental results showed thatastaxanthin has potent in vivo and in vitro inhibiting effects on melanoma tumor growth for developingas chemotherapeutic agents.

Equisetum ramosissimum, a genus of Equisetaceae, is a medicinal plant that can be separated into ethyl acetate (EA), dichloromethane (DM), n-hexane (Hex),methanol (MeOH), andwater extracts. EAextract was known to have potent antioxidativeproperties, reducing power, DPPH scavenging activity, and metal ion chelating activity. This study compared these five extractsin terms of their inhibiting effects on three human malignant melanomas: A375, A375.S2, and A2058. MTT assay presented thenotion that both EA and DMextracts inhibited melanoma growth but did not affect the viabilities of normal dermal keratinocytes (HaCaT) or fibroblasts. Western blot analyses showed that both EA and DM extracts induced overexpression of caspase proteinsin all three melanomas. To determine their roles in melanogenesis, this study analyzed their in vitro suppressive effects onmushroomtyrosinase.All extracts except for water revealedmoderate suppressive effects.None of the extracts affected B16-F10 cellsproliferation. EA extract inhibited cellular melanin production whereas DMextract unexpectedly enhanced cellular pigmentationin B16-F10 cells. Data for modulations of microphthalmia-associated transcription factor, tyrosinase, tyrosinase-related protein 1and tyrosinase-related protein 2 showed that EA extract inhibited protein expression mentioned above whereas DMextract had theopposite effect. Overall, the experiments indicated that the biofunctional activities of EA extract contained in food and cosmeticsprotect against oxidation, melanoma, and melanin production.

Melanoma is the deadliest cancer. We identified 7-hydroxydehydronuciferine (7-HDNF) isolated from the leaves ofNelumbo nucifera Gaertn cv. Rosa-plena to be a bio-active agentthat antagonizes melanoma tumor growth in mice xenograftmodel in vivo. Cell proliferation assay demonstrated stronganticancer effects of 7-HDNF to exhibit a dose-dependentbehaviour and displayed minor cytotoxicities on normal humanskin cells, includingepidermal keratinocytes and melanocytes, and dermal fibroblasts. With acridine orange (AO) staining andflow analysis, we found 7-HDNF induced the formation ofintracellular vacuoles and the augmentation of acidic vesicularorganelles (AVO). The

apoptoticcell death ratio was measuredvia two-dimensional flow cytometry by annexin V-fluoresceinisothiocyanate (FITC)/propidium iodide (PI) double stained toconfirm the cellular membrane asymmetry lost. Onedimensionalflow cytometric analysis showed 7-HDNF increasedthe cellular arrest in cell cycle at the G2/M phase. ThroughWestern blot examinations, protein expressions were discoveredto verify autophagy and apoptosis response mechanisms sharingthe associated pathways. Finally, 7-HDNF presented ahigh-quality antimigratory activity in wound-healing assay. Overall, 7-HDNF presented high-quality anticancerbio-functions and inhibited melanoma tumor growth in vivoand in vitro.

Bromodomain-containing protein 4 (BRD4) has recently emerged as an attractive epigenetic target foranticancer therapy. In this study, an iridium(III) complex is reported as the first metal-based, irreversibleinhibitor of BRD4. Complex 1a is able to antagonize the BRD4-acetylated histone protein–proteininteraction (PPI) in vitro, and to bind BRD4 and down-regulate c-myc oncogenic expression in cellulo.Chromatin immunoprecipitation (ChIP) analysis revealed that 1a could modulate the interactionbetween BRD4 and chromatin in melanoma cells, particular at the MYC promoter. Finally, thecomplex showed potent activity against melanoma xenografts in an in vivo mouse model. To ourknowledge, this is the first report of a Group 9 metal complex inhibiting the PPI of a member of thebromodomain and extraterminal domain (BET) family. We envision that complex 1a may serve as auseful scaffold for the development of more potent epigenetic agents against cancers such asmelanoma.

Three new butanolides, isophilippinolide A, philippinolide A, and philippinolide B, and an amide, cinnaretamine, were isolated from the roots of Cinnamomum philippinense to be identified by spectroscopic analysis. Four isolated compounds were screened to examine their radical-scavenging ability, metal-chelating power, and ferric-reducing antioxidant power assay (FRAP). Cinnaretamine showed powerful antioxidative properties in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay and a reducing activity; all compounds presented minor inhibition of metal-chelating capacities. The effects of anti-tyrosinase of C. philippinense constituents were determined by the level of the suppression of hydroxylation that turned from L-tyrosine to L-dopathrough an in vitro mushroom tyrosinase assay, and all testing samples illustrated slight mushroom tyrosinase inhibitoryproperties. Isophilippinolide A exhibited inhibitory effectivenesses against the A375.S2 melanoma cell line in a cell viability assayat concentrations ranging from 0 to 200 μM for 24 h. Propidium iodide staining and flow cytometry analyses were applied toassess cell cycle accumulative distribution. It was discovered that isophilippinolide A caused sub-G1 phase accumulation inpositive correlation for apoptosis to inhibit cell growth. Further investigation revealed that isophilippinolide A induced A375.S2cells with an increase of caspase-dependent apoptotic proteins to trigger correlated pathway mechanisms according to Western

blotting results. Finally, isophilippinolide A displayed only low cytotoxicities to human normal epidermal cells (melanocytes) anddermal cells (fibroblasts). Altogether, the results implied C. philippinense compounds could be considered functional ingredientsin cosmetics, foods, and pharmaceutical products, particularly for their anticancer ability on human skin melanoma cells.

Kinetically inert metal complexes have arisen aspromising alternatives to existing platinum and rutheniumchemotherapeutics. Reported herein, to our knowledge, is thefirst example of a substitutionally inert, Group 9 organometalliccompound as a direct inhibitor of signal transducer andactivator of transcription 3 (STAT3) dimerization. Froma series of cyclometalated rhodium(III) and iridium(III)complexes, a rhodium(III) complex emerged as a potentinhibitor of STAT3 that targeted the SH2 domain and inhibitedSTAT3 phosphorylation and dimerization. Significantly, thecomplex exhibited potent anti-tumor activities in an in vivomouse xenograft model of melanoma. This study demonstratesthat rhodium complexes may be developed as effective STAT3inhibitors with potent anti-tumor activity.

Biography:

Muhammad Khurram Waqas is an Assistant Professor in Pharmaceutics in Institute of Pharmaceutical Sciences, University of Veterinary And Animal Sciences, Lahore, Pakistan. He earned his PhD degree from the Islamia University of Bahawalpur, Pakistan in 2015. The topic of his PhD Dissertation was “Formulation development and non-invasive in vivo evaluation of cosmetic emulsions containing various botanical extracts”. He has published over 20 research articles on cosmeceuticals sciences, health sciences, natural products and clinical research. His research interest including anti aging, transdermal drugs, cosmetics (safety, efficacy and quality control), hydrogels and reactive oxygen species.

Abstract:

The demand for botanical extracts in cosmeceuticals is growing day by day. Botanical extracts that support the skin integrity; vigour and texture are extensively used in cosmetics. Phytotherapy has been applied for decades to manage conditions of the skin and miscellaneous dermatological ailments consisting of Acne, Eczema, Inflammation, Psoriasis and Phototoxicity. The present paper  highlights the applications of Vitis vinifera seeds extract in cosmetic formulations due to its minor  toxicity with a short overview of the active constituents responsible for effective outcomes. The applications of grape seeds extract in dermatological care e.g. Stimulation of Collagen Synthesis, Protection of skin from UV radiations, anti-inflammatory, Skin lightening effects, free radical neutralizing effects has been elaborated. This is an effort to give brief overview on cosmetic impacts of grape seeds and its major components

Biography:

Marjan Farshadi has her expertise in science-based natural remedies. After years of experience in research, natural health, medicine and pharmaceuticals, she established a research-based company to continue in-depth research and development of natural health products based on scientific evidences. Increasing interest in natural health remedies, weak regulations and manufacturing of natural health products by non-science-based settings can lead to serious conditions. She is determined to fill the gap and connect natural health products to science.

Abstract:

Wound healing is a complex process that involves several phases that range from coagulation, inflammation, accumulation of fundamental elements, to proliferation, formation of fibrous tissues and collagen, contraction of wound and formation of granulation tissue and scar.

Rhizome of Curcuma longa L. (common name: turmeric), the main spice of curry, has been used traditionally as a wound healing agent. Researchers around the world have studied the effect of curcumin, the most active ingredient of turmeric, for many years due to its bio-functional properties, especially antioxidant, radical scavenger, antimicrobial and anti-inflammatory activities, which play a critical role in the wound healing process. Furthermore, curcumin stimulated the production of the growth factors involved in the wound healing process, and so curcumin also enhanced the management of wound restoration.

Studies have provided evidence of the ability of curcumin to reduce the body's natural response to cutaneous wounds such as inflammation and oxidation. The recent literature on the wound healing properties of curcumin have also shown that curcumin has the ability of enhancing granulation tissue formation, collagen deposition, tissue remodeling and wound contraction. It has also been reported that curcumin may modulates wound healing in vitro in a biphasic dose response manner i.e. may be stimulatory at low doses and inhibitory at higher doses. Curcumin was reported to facilitate fibrinolysis and cellular migration during wound healing by modifying urokinase plasminogen activator expression.

Studies to date have shown that compared to its oral administration, topical application of curcumin has more noticeable effects on wound healing due to the greater accessibility of the drug at the wound site.

I will be reviewing the effect of curcumin on the wound healing, proposed mechanisms of action, and different curcumin-based cutaneous products and their effect on the wound healing.

Biography:

Zamir H is currently working in the Departments of Dermatology, Rambam Health Care Campus and the Bruce Rappaport Faculty of Medicine, Haifa, Israel

Abstract:

Background: PDM is a rare variant of melanoma. It is confined to the dermis and/or subcutis without epidermal component. Hence, histologically alone, it cannot be distinguished from a melanoma metastasis. Careful clinical history, examination and proper imaging are required to exclude metastatic disease. Diagnosing such a lesion as PDM or as a metastasis has significant impact on the proper management and on the prognosis.

Our experience and insights cast some light on this problematic clinical situation.

Methods: We retrieved all 36 clinically diagnosed PDM patients from our prospectively collected database of 1600 melanoma patients surgically treated in a tertiary melanoma center between 1995 and 2015. Strict focused pathology revision excluded 23 patients who failed to meet all criteria for PDM set forth by Swetter et al. 13 patients were in-depth investigated regarding clinical, histopathological parameters, surgical treatment and outcome.

Results: 13 PDMs, median "thickness" – 5.5 (range 2 to 11) mm, median mitotic rate 4 (range 0 to 17)/mmsq, formed this series.11 pts (84.6%) are still alive after median follow up of 56 (range 12 to 120) months.  3 of 13 patients had a positive sentinel lymph node followed by completion dissection.

Discussion:

It seems that when PDM is diagnosed, it can be successfully treated as a primary melanoma (rather than a metastasis) including Sentinel node sampling and completion dissection

The actual "thickness" of these melanomas, as well as their  mitotic rates, are associated with better prognosis than same-thickness cutaneous melanomas. 

Conclusions: Diagnosing PDM demands careful clinical and histological reviews. PDM has favorable outcome compared to primary cutaneous same –thickness melanoma. Wide local excision and Sentinel lymph node biopsy seem appropriate and worthwhile, once these lesions are deemed primary melanomas

Biography:

Ass. Prof. Zoran Žgaljardić M.D., Ph.D. is an maxillofacial surgery consultant, head and nesck plastic surgery consultant and general cosmetic surgeon - international of  International board of cosmetic surgery (IBCS). He is the Board member of Academy of Cosmetic Surgery, Croatian representative in International Academy of Cosmetic surgery and EUSAS Board ( Europen Society of Aesthetic Surgery).He is also one of the co-founders of World Academy of Cosmetic Surgery.He is Pionir in laser liposuction and invited speaker in workshops in  lasers lipolysis.

Abstract:

Laser lipolysis with 1470 nm can be done as a procedure  for itself but in most cases is followed by liposuction. The main goal of this procedure is to dissolve unwanted fat.

The secondary effect of this technology is skin tightening which is direct consequence of the photothermal effect which stimulates neocolagenesis.Target for the 1470 nm wave length water molecules. By adding infiltration of Klein's solution in the subcutaneous layer and fat subdermal tissue both effects are higher and the results are more evident.Technique is atraumatic and less painful with minor hematomas and edema of the skin than after standard liposuction. Laser lipolysis of the facial area can be done without subsequent liposuction. The result is lifting effect of the skin so we can call lit endolight lifting and can be done as an initial part of surgical lifting or as an isolated procedure.When laser lipolysis is used in „big“  liposuction (5000 ml) the aspiration of the fat content is more  dense comparing with standard liposuction which means that really  more fat is removed because it was dissolved before aspiration- liposuction.Subdermal region is stimulated with energy and that improves skin texture and final adaptation of skin because of new collagen formation

Biography:

The aim of the study is to determine effects of Skin Promotion Program (SPP) in reducing occupational skin diseases symptoms and improvement of protective health behaviors in young workers who are hairdresser/barber apprentice at vocational training centers. The study was designed as pre- and post-test control group research with repetitive measurement, and consisted of 100 young workers (Intervention=50, control=50 ) with a score of 2 points or less on eczema symptom, educated and who were of two different. The SPP program was developed on the basis of the health promotion model that applied to intervention group. The program consists of evidence-based education and counseling practices aimed at improving health and preventive health behaviors (hand washing, using latex-free (nitrile) gloves, cotton gloves and moisturizers). Both groups were examined by a specialist physician to determine the degree of eczema symptoms before and after intervention. The monitoring processes were made with workplace health surveillance, message, telephone call, WhatsApp messages, check-lists and photo records. The data collection tools were; dermatology life quality index, self-efficacy scale, Turkish Nordik occupational skin questionnaire, eczema symptom scale assessment form, protective behavior monitoring form. The mean age of young workers was found to be 20.77±4.85. After the program, there was a decrease in favor of the intervention group at the eczema symptoms (redness, itching, dryness, cracking/splitting, flake/scaling and total eczema) score between the both groups. Also; within the intervention group, there was a statistically significant difference between the scores of eczema symptom and skin protection behaviors before and after the program (pË‚0.05). The SPP is effective in reducing of eczema symptoms and improving preventive health behaviors and self-efficacy of young workers who work as hairdresser/berbers

Abstract:

Emine Kurtulus is a Research Assistant at Istanbul University - Florence Nightingale Faculty of Nursing, Public Health Nursing department. She completed her Graduation at Istanbul University Institute of Health Sciences. She has five articles in international and national journals and has been serving as a Journal Referee. Her research interest is in the area of “Occupational skin diseases in young workers, apprentice skin diseases”.