Yun Zhou
Johns Hopkins University School of Medicine, USA
Title: Quantitative PET from Brain to Whole-body
Biography
Biography: Yun Zhou
Abstract
Brain PET is a well-established quantitative functional imaging technique to measure physiological and biochemical process.
As recent advances in hybrid imaging technology, such as PET-CT and PET-MRI, for whole-body PET imaging, there are
urgent needs to develop and validate technologies for quantitative whole-body PET from data acquisition to quantification. The
fundamentals of quantitative PET developed in last three decades which include kinetic modeling approach and parametric
imaging algorithms will be briefly reviewed. Recent developments in quantitative PET imaging on dopamine and serotonin
receptors and transporters will be highlighted. Tremendous efforts have been made to extend quantitative brain or organspecific
PET to dynamic whole-body PET in last few years. We investigated the feasibility of quantitative dynamic whole-body
PET via multi-bed multi-pass technology. Optimization in data acquisition and quantification were studied by both computer
simulation and an ongoing multi-center multi-tracer dynamic whole-body PET project. The potentials and challenges in
quantitative whole-body PET in clinical diagnosis, monitoring disease progression, responses to treatments or psychological/
pharmacological stimulations will be discussed with our promising results.