Mian Wu
University of Science and Technology of China, China
Title: Regulation of LncRNA-MIF in c-Myc homeostasis
Biography
Biography: Mian Wu
Abstract
c-Myc is one of the most important proto-oncogenes and is activated in over half of human cancers. However, it remains unclear how the c-Myc protein level is regulated. Here we show that lncRNA-MIF (c-myc inhibitory factor), a c-Myc-induced long non-coding RNA, acts as a competing endogenous RNA (ceRNA) for miR-586 and reduces the inhibitory effect of shared miR-586 on Fbw7, an E3 ligase for c-Myc, leading to increased Fbw7 level and subsequent c-Myc degradation. This creates an autoregulatory feedback loop between c-Myc and Fbw7 that involves both a long and a micro noncoding RNAs. Interestingly, levels of all components of this network including c-Myc, lncRNA-MIF, miR-586 and Fbw7 are found to be higher in tumor cells than in normal cells. The c-Myc-lncRNA-MIF-miR-586-Fbw7 axis represents a novel mechanism by which c-Myc homeostasis is finely regulated. Additionally, lncRNA-MIF is able to inhibit the glycolysis and tumorgenesis via suppressing c-Myc.