Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 7th Global Neurologists Annual Meeting on Neurology and Neuro Surgery Vienna, Austria.

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Scientific Program Day 1
Scientific Program Day 2
Scientific Program Day 3

Day 2 :

Keynote Forum

Rajendra Badgaiyan

University of Minnesota, USA

Keynote: Detection of Acute Changes in Neurotransmission in the Live Human Brain

Time : 09:30-10:10

Conference Series Neurologists 2016 International Conference Keynote Speaker Rajendra Badgaiyan photo
Biography:

Badgaiyan is the Director and Principal Investigator of Molecular and Functional Brain Imaging Laboratory and Director of the University Laboratory for Advanced Radiochemistry. Dr. Badgaiyan graduated from Gandhi Medical College, Bhopal in India and completed his psychiatry residency training at Harvard Medical School.He had postdoctoral training in cognitive neuroscience at University of Oregon, University of Pittsburgh and Harvard University. He also had training in molecularimaging at Massachusetts General Hospital, Boston, and clinical research training at MIT. He is board certified in General Psychiatry and in Addiction Medicine. Dr.Badgaiyan is a member of a number of National and International Scientific Societies. He is the Editor-in-Chief of 7 international scientific journals and a member of the editorial board of over 40 other scientific publications. He has organized a number of International conferences and symposia.

Abstract:

Current neuroimaging techniques are not very good at detecting acute changes in the levels of neurotransmitters in the live human brain. As a result, we have poor understanding of their roles in the regulation of human cognition and behavior.We developed the single scan dynamic molecular imaging technique to detect, map and measure task-induced acute changes in dopamine neurotransmission in the live human brain. The technique exploits the competition between a neurotransmitterand its receptor ligand for occupancy of the same receptor sites. We used the technique to detect dopamine released during cognitive, behavioural and emotional task performance and also to examine novel hypotheses concerning pathophysiology of psychiatric and neuropsychiatric conditions, including ADHD and PTSD. Since the technique provides information that cannot be obtained by other means, it could a valuable tool not only to study human cognition and behavior bit also to explore neurocognitive bases of psychiatric conditions.

Keynote Forum

Rong Fu Wang

Peking University Health Science Center, China

Keynote: Study in vivo on Neuroreceptor and Neurotransmitter Imaging with Radionuclide Tracing

Time : 10:10-10:50

Conference Series Neurologists 2016 International Conference Keynote Speaker Rong Fu Wang photo
Biography:

Rong Fu Wang has completed his MD at the age of 27 years from Fujian Medical University in 1982, postdoctoral studies from Paris V University School of Medicine in 1993 and his PhD at the age of 40 years from Toulous IIl University in 1995. He is the director of Department of Nuclear Medicine, Peking University Health Science Center. The research interests of Dr. Wang include experimental study and clinical application of molecular and clinical nuclear medicine. He has published more than 400 papers in reputed journals and has been serving as many editorial board member of reputed journals at home and abroad. He has published 3 monographs, and has got 3 patents of invention and 3 provincial and ministerial Awards.

Abstract:

Neuroreceptor and neurotransmitter imaging is a new developed domain in the study of nervous nuclear medicine in the 21st century. Recently in the biological area, the exploration of receptor function and its biological characteristics in molecular medical level and the diagnosis and management of receptor disorders are an advanced domain of international medical science investigation. The neuroreceptor and neurotransmitter imaging in vivo using radioligand is a new molecular medicine of medical tracing technique combined with molecular biology and nuclear medicine, i.e. the molecular nuclear medicine will be a new means applied for detecting functional brain abnormalities in nuclear neurology.Neuroreceptor and neurotransmitter imaging with radionuclide tracing in vivo have been greatly developed recently.Distribution, density, and activity of receptors in the brain can be visualized by the radioligands labeled for emission computed tomography(ECT), including PET(positron emission tomography) and SPECT(single photon emission computed tomography).The continual emergence of new positron radiopharmaceuticals, especial positron neuroreceptor and neurotransmitter imaging agents, further promotes and extends the clinical applications of PET, PET/CT and PET/MR. The researches on PET, PET/CT and PET/MR have become an attractive area now. The functional and quantitative imaging for several receptors, such as dopamine receptors and dopamine neurotransmitter, serotonin receptors, cholinergic receptors, benzodiazepine receptors, and opioid receptors, have clinical importance. The preparation of neuroreceptor and neurotransmitter imaging agent, foundation of physio-mathematical model, and the development of nuclear medicine instrument are the main points. In present review, we will concentrate on introducing the development ofneuro receptor and neurotransmitter

Break: Networking and Refreshment Break 10:50-11:10 @ Foyer

Keynote Forum

Rong Fu Wang,

Peking University Health Science Center, China

Keynote: Generalization and optimization of a population-based input function estimation and approach for quantification of sparsely sampled dynamic 18F-FDG PET/CT data

Time : 10:10-10:50

Biography:

Rong Fu Wang has completed his MD at the age of 27 years from Fujian Medical University in 1982, postdoctoral studies from Paris V University School of Medicine
in 1993 and his PhD at the age of 40 years from Toulous IIl University in 1995. He is the director of Department of Nuclear Medicine, Peking University Health
Science Center. The research interests of Dr. Wang include experimental study and clinical application of molecular and clinical nuclear medicine. He has published
more than 400 papers in reputed journals and has been serving as many editorial board member of reputed journals at home and abroad. He has published 3
monographs, and has got 3 patents of invention and 3 provincial and ministerial Awards.

Abstract:

18F-FDG uptake rate constant Ki is a most interested and commonly used parameter for absolute quantification of 18F-FDG
PET/CT. Ki is usually estimated by fitting a kinetic model with plasma input function (PIF) to the measured dynamic PET
data. The need for arterial blood sampling to measure PIF (mPIF) is a main barrier to estimate Ki for clinical 18F-FDG PET.
Two existing noninvasive PIF estimation methods, image derived PIF and simultaneous fitting method with kinetic model and
parametric PIF, require image data to be acquired continuously and immediately post tracer injection. The objective of the study
is to validate and optimize a generalized population-based PIF estimation method for noninvasive quantification of dynamic
18F-FDG PET for sparsely sampled PIF. Eight 60-min 27-frame monkey dynamic 18F-FDG PET studies were collected from a
Philips Gemini GXL PET/CT with 3D data acquisition mode. Total 34 arterial blood samples were taken during PET scan as:
22 samples for the first 4 min, and followed by sampling at 5, 6, 8, 10, 12, 15, 20, 25, 30, 40, 50 and 60 min. Time activity curves
(TACs) of 7 cerebral regions of interests (ROIs) were generated from each study. A generalized population-based approach to
recover full kinetics of the PIF from sparsely sampled blood data is proposed. The estimated PIF (ePIF) from the incomplete
PIF sampling data was determined by interpolation and extrapolation using scale-calibrated population mean of normalized
PIFs. The optimal blood sampling scheme with given sample size m was determined by maximizing coefficient coefficients
of Ki estimates between the Kis from measured PIF (mPIF) and estimated PIF (ePIF). The leave-two-out cross validation was
performed. The linear correlations between the Ki estimates from the ePIF (with optimal sampling scheme) and those from
the mPIF were: Ki(ePIF; 1 sample at 40 min) = 1.015Ki(mPIF) -0.000, R2 = 0.974; Ki(ePIF; 2 samples at 25 and 50 min) =
1.029Ki(mPIF) - 0.000, R2 = 0.985; Ki(ePIF; 3 samples at 8, 20, and 50 min) = 1.039Ki(mPIF) - 0.001, R2= 0.993; and Ki(ePIF;
4 samples at 8,12, 25, 40, and 55 min) = 1.02Ki(mPIF)-0.000, R2=0.997. The correlations of R2 from leave-2-out validation
study were 0.978±0.007, 0.990±0.006, and 0.996±0.003 (mean ±SD) for 1, 2, and 3 samples of optimal sampling scheme,
respectively. The generalized population-based PIF estimation method is a reliable method to estimate PIFs from incomplete
blood sampling data for quantification of dynamic 18F-FDG PET using the Gjedde-Patlak plot.

Keynote Forum

Haris Huseinagic

Clinical Center Tuzla, Bosnia and Herzegovina

Keynote: Voronoi diagrams in the treatment of giant aneurysms of a.basilaris - technique

Time : 11:10-11:30

Biography:

Haris Huseinagić is the head of Department of radiology and nuclear medicine in University Clinical Center Tuzla Tuzla, Bosnia and Herzegovina

Abstract:

Endovascular treatment of giant basilar artery aneurysm is a complex procedure that requires the work of an experienced team and
a range of materials and techniques available.
Treatment of a giant aneurysm of the basilar artery in the body which includes the initial parts of both arteriae cerebelaris
posterior was a special kind of technical challenges and use techniques Waffle cone.
Technically it was not possible to implement the classic waffle cone technique, and made modifications to the horizontal stenting
in the right artery cerebelaris posterior, and above it are set Koil, and the aneurysm successfully closed with rear patent cerebellar
artery. Technical correctly written procedure with good outcome for the patient left the question of objective verification of results.
Using Voronoi diagrams and indirect visualization of the 3D models of aneurysms with the analysis of the dynamics of flow (flow
dynamics), an objective verification of results.
Results of verification coincide with the real results to the patient.
The new method of analysis of endovascular treatment has proven to be an effective model verification results

Keynote Forum

Mirza Moranjkic

Clinical Center Tuzla, Bosnia and Herzegovina

Keynote: Endovascular stroke treatment- novel perspective

Time : 11:30-11:50

Biography:

Mirza Moranjkic is a renowned neurosurgeon of Clinical Center Tuzla Tuzla, Bosnia and Herzegovina

Abstract:

Introduction: Fusiform and some wide-neck aneurysms remained unaddressed by both reconstructive surgical and endovascular
techniques until the introduction of dedicated intracranial self-expandable stent.
Aim: The aim of the current study was to review a single center experience with stent-assited aneurysm coilling.
Results: Approximately 200 endovascular procedures were performed in our department for various cerebrovascular conditions
over the course of some 30 months. Of those, there were over 100 aneurysm patients, and over 50 patients were treated with stentassisted
coilling. We encountered 2 technical complications (one stent migration, and one stent dislodgment). No thromboembolic
complications were noted, and none of those technical complications proved to be clinically relevant.
Conclusion: Stent-assisted aneurysm coiling is a safe and highly effective endovascular technique that provides us with means to treat
aneurysms previously deemed untreatable by endovascular means.

Keynote Forum

Biljana Milatović

Clinical center of Serbia, Serbia

Keynote: Morphological parameters for bleeding in arteriovenous malformations of the brain by multidetector CT angiography

Time : 11.50-12.10

Biography:

Biljana Milatović has completed her postgraduate Specialist academic studies in Radiology with the paper entitled “The Comparison of Digital Subtraction Angiography and
Multi slice CT Angiography in the Evaluation of Intracranial Aneurysms“ and completed her PhD in neuroradiology with paper entitled as “ Predictive factors for haemorrhage
in arteriovenous malformations by digital subtraction angiography and MDCT angiography of the brain”. In 2006 and 2007 she worked as a general practitioner at the
Institute for the Medical Protection of Mother and Child, at the Radiology department. She started working as a general practitioner at Radiology – Neurosurgery department
(Interventional Neuroradiology, MSCT neuroradiology imaging and MRI imaging) in October 2007. She has worked at the Emergency and Trauma Center since September
1st, 2009 (Diagnostic emergency neuroradiology, Ultrasound diagnostics and x-ray diagnostics). Dr. Biljana Milatović is currently working at the Clinical center of Serbia
as a neuroradiologist in Center for Radiology and Magnetic resonance Imaging since February 1st, 2008. She is a member of the European Association of Radiologists
since 2008.

Abstract:

Patients with brain arteriovenous malformation (AVM) have a certain risk to bleed, and the goal of this study is to examine the
effect of radiological and clinical predictive characteristics of AVM hemorrhage using multidetector CT angiography (MDCT).
Material: this is a series of 57 patients with a mean age of 35.46 years, who were diagnosed at the Institute for Radiology and MRI,
while the same were hospitalized at the Clinic of Neurosurgery, Clinical Center of Serbia in the period from January 2008 to March
2016. For all patients, the diagnosis was made using MDCT angiography. Two groups of patients were observed. The first group
includes patients who were not initially presented by hemorrhage, while the second group was initially presented by hemorrhage.
Both groups were treated with medical therapy, or a combination of medical therapy with embolization / surgery / radiotherapy.
Results: Deep venous drainage (p <0.05), the combined arterial supply from different basins (p <0.05) with a length> 60mm, venous
dilation present in the drainage vein (p <0.01) and the angle of casting supply arteries in the nidus (p <0.01), carry a risk of repeated
bleeding. In the group of patients who had initial hemorrhage a mean value of the sized corner casting was 130o, while the group that
did not had initially bleeding mean value of the size of the measured angle was 103.81 with a standard deviation of 17.21 (p <0.01).
Conclusion: arterio-venous malformations with the deep venous drainage from the carotid and VB basin, the length of the feeding
arteries> 60mm, angle of casting feeding arteries in the nidus ≥ 130 ° and dilatation and / or venous aneurysm drainage vessel are
predictive model for clinical presenting by hemorrhage.
Key Words: AVM of the brain, bleeding, morphological parameters4

Keynote Forum

Geetika Singla

Command Hospital, India

Keynote: Endovascular management of Acute Ischemic Stroke: Our experience

Time : 12:10-12:30

Biography:

Geetika Singla is an alumnus of the Armed Forces Medical College, Pune . After serving for 7 years in Armed Forces Medical Services which included tenures in rural
peripheral areas , She is pursuing MD(Radiodiagnosis) at Command Hospital , Bangalore.Her areas of interest are intervention radiology and neuroradiology.

Abstract:

Acute Ischemic stroke is a medical emergency and accounts for a worldwide mortality of 6.2 million lives each year. There has been
a revolution of sorts in the endovascular management of acute ischemic stroke in the past two years. Our hospital experience in
acute ischemic strokes presenting in the window period has evolved with a view to better the management outcomes of such cases.
Based on intra-hospital logistics imaging in these cases has evolved from MRI & MRA to NCCT & CTA and more recently to CT
based collateral scoring. The endovascular management similary has seen the use of various stentreivers and more recently the use of
thromboaspiration using the ADAPT technique utilising the Penumbra system. The paper shall also cover the current evidence in the
endovascular management of Acute ischmic stroke

Keynote Forum

Rafael Martins Ferreira

University Federal de Santa Catarina, Brazil

Keynote: Spatial and tFunctional MR Imaging in preoperative planning of glial tumorsemporal correlations between amyloid-PET (Florbetapir and PiB) retention and white matter intensity

Time : 12:30-12:50

Biography:

Rafael Ferreira, MD is professor at Universidade Federal de Santa Catarina, in Florianopolis Brazil. His neuroradiology training was done at Hospital Beneficencia
Portuguesa ( Sao Paulo, Brazil) and Massashusetts General Hospital ( Boston, US). He Works at Diagnostico das Americas (DASA – Florianopolis unit) and is the director
of MF imagens in Biguacu, Brazil. He has a 8 year experience doing functional MRI in surgical planning of brain tumors , publishing papers in reputed jornals and serving
as editorial board member of repute.

Abstract:

Functional Magnetic Resonance Imaging (fMRI) is a technique that takes advantage of the diferences in magnetic susceptibility
between oxyhemoglobin and deoxyhemoglobin. Once the goal of neurosurgery is to maximize patient safety and to minimize
residual tumor, fMRI may be an alternative, non-invasive and reproducible tool for assessing potential risk of dysfunction resulting
from brain ressection near eloquente cortex. Tumoral mass effects can distort normal cortical anatomy losing anatomical landmarks.
So fMRI studies with specific –tasks combines structural with physiological information and provides data helping in localizing
cortex controlling language, motor, sensory, hearing and visual pathways , according to tumor region. In addition, many studies
confirm the large individual variability in cortical localization of language and fmri data may aid in the determination of language
laterality and localization of Wernicke’s and Broca’s areas in cases of temporo-parietal lesions. Althout fmri can show cortical signals,
imaging the White matter bundle may be just as crucial. Therefore Diffusion Tensor imaging complements fMRI examinations and
provides the surgeon with fiber-tracking information. In summary, fMRI data can alter a neurosurgical approach to a tumor, indicates
eloquent cortex in distorted areas, guide surgical resections or even emphasize too high risk in total tumor resection in other cases.
Clinical cases showing such fMRI applications and a literature review about clinical outcomes is presented.

Keynote Forum

Roberto Cartolari

S. Giovanni Hospital, Switzerland

Keynote: CT and MR Axial loaded imaging of the Spine

Time : 12.50-13.10

Biography:

Born in Urbino (PU), Italy, in 1955, is married with Maria Chiara and , has one daughter, Ginevra. Degree in Medicine and Surgery, University of Modena, 1980, board on
Radiology, University of Modena in 1984, board on Neurology, University of Siena in 1994. He Patented the device, “Axial Loader” and development of neuroradiological
imaging techniques known as” Axial Loaded - Computed Tomography - AL-CT “ and “ Axial Loaded Magnetic Resonance - AL-MR “for the in vivo biomechanical study
of the spine in 1992. At present is Senior Assistant Radiologist at the Radiology Service, Ospedale S. Giovanni – EOC Bellinzona, Switzerland. He has published as
Author and co-author many scientific publications, abstracts and reports in national and international journals. He also collaborated on several chapters on international
treaties of Neuroradiology. Main interests are “Diagnostic and Spinal non-vascular Interventional Neuroradiology, with special reference to CT and MRI, “ Biomedical
applications of Virtual Reality,” Biomechanics of the spine and joints. “ He is Ordinary Member of the Italian Association of Neuroradiology – AINR,- Full Member of the
European Society of Neuroradiology – ESNR

Abstract:

The comprehension of the inner mechanism of low back pain is hard and often the conventional diagnostic approach can’t reveal
the exact cause of the disease. The functional radiologic study of the spine is not so precise, and only bone structures are directly
seen. More complex conventional radiologic functional studies like myelography and stereo-radiology are invasive or obsolete and
difficult to obtain; in any case the informations obtained are quite always “indirect”, since anatomical structures as discs, roots and
ligaments are not visible.
In last 20 years, a possible “in vivo” bio-mechanic approach in the study of the spine has been proposed with the use of devices like
the Axial Loader and the Dynawell able to produce a variable axial load on the spine during CT or MR examinations on conventional
diagnostic units. This allows to directly image all the anatomical structures in a precise way during a work.
This lecture reviews the personal experience in the study mainly on the lumbar spine with the Axial Loader (AL) both in CT and
in MR. The Axial Loader device is described together with the CT and MR acquisitions. The disc, intersomatic and articular facet
changes obtained during the examinations are described with a breakdown of the classification of findings as Elementary Dynamic
Modifications (EDMs) or Complex Dynamic Modifications (CDMs). From this data derived a possible functional model of the
lumbar spine. A particular look will be given to the post-surgical functional evaluation of the lumbar spine. Early data from AL
studies of pediatric isthmian lysis with MR will be presented. Finally a comparison with data from studies with MR units that allows
real orthostatic spine studies will be attempted.