Moatasem Wdaah Man Allh
Sultan Idris university, Malaysia
Title: Evaluation of Oxidative Stress (MDA) and some Immunological Markers in Immune Response in Patients with Rheumatoid Arthritis at Al Nasiriya City, Iraq
Biography
Biography: Moatasem Wdaah Man Allh
Abstract
Objective: This study aimed to determine the level of serum indicators of cellular oxidative stress and the antioxidant the relevance with inflammations parameters, establishing the inflammatory profile in patients with rheumatoid arthritis.
Method: The sample of the study take in 50 patients with RA. They were confirming the dealings of the 2007 American College of Rheumatology, also the sample of the study include fifty person seemingly healthy volunteers were included in this study. We determined the plasmatic levels of malondialdehyde, compare with the inflammatory parameters such as CRP, ESR, RF, calculation of total WBC and diffraction numerous of WBC. In addition, the phagocytosis processes.
Results: in comparison to controls, patients with rheumatoid arthritis presented high concentrations of lipid peroxidation products (determined by plasmatic levels of malondialdehyde, as well as the study shown high signification between the studied groups according the immunological markers
Conclusion: our results indicate the presence of molecular damage determined by oxygen free radicals in patients with rheumatoid arthritis and this is play main role in immune response of patients.
Key word: C-reactive protein, free radicals ROS, MDA, neutrophil, rheumatoid arthritis.