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G.Kaarthikeyan

G.Kaarthikeyan

Saveetha Dental College and Hospitals, India

Title: Association analysis of 3’UTR gene polymorphisms of TLR4,NLRP3 and miRNA with chronic Periodontitis in south Indian ethnicity.

Biography

Biography: G.Kaarthikeyan

Abstract

Periodontitis is a chronic inflammatory disease of multifactorial etiology. Although gram negative  anaerobes are essential in initiating the disease, many other factors determine the course and progression of the periodontal destruction. Among the various risk factors , the genetic component of the host plays a major role in periodontal destruction. The microbial agents  are first screened by the pattern like receptors – Toll like receptors(TLR) and the signals are processed intracellularly by Nod like receptors -NLRP3. Thus the aim of my study was to analyse the association of 3’UTR polymorphisms of TLR4,NLRP3 gene  and the micro RNAs regulating these region. The subjects were stratified into three groups -chronic periodontitis ,aggressive periodontitis and controls. The sample size was 240. DNA extraction from blood samples done  and the polymorphisms were analysed using real time PCR. The TLR4(rs11536889), NLRP3(rs10802501), miR-146a (rs2910164) were analysed in this study.