Paras Kumar Mishra
Associate Professor
University of Nebraska Medical Center
USA
Biography
Dr. Paras Kumar Mishra did BSc and MS in Biological science with specialization in Zoology from India. His Ph.D. dissertation was from Banaras Hindu University (a reputed university in India) on understanding the genetic basis of speciation. His postdoctoral works was basically on cardiac physiology from USA. As a faculty, the major focus of our research is to understand how heart undergoes structural and functional remodeling especially in diabetes, how it is regulated by specific microRNA (miR). He was also interested in investigating the role of extracellular matrix (ECM) and matrix metalloproteinases (MMPs) in heart failure. Their recent results revealed that MMP9 and miR-133 plays pivotal role in diabetic cardiomyopathy. Since, the role of ECM stiffness is unequivocal in stem cell apoptosis, we are interested to investigate the mechanism of ECM mediated cardiac progenitor cell apoptosis / impairment of differentiation in diabetes. The long term goal of research is to discover an intervention tool to improve cardiac function in pathological heart using microRNAs and stem cells.
Research Interest
MicroRNomics of cardiovascular diseases , Diabetic cardiomyopathy