Oyebola Sonuga
Department of Chemical Pathology, University College Hospital, Ibadan, Nigeria
Title: Insulin resistance index and pro-atherogenic lipid indices in offspring of people with diabetes
Biography
Biography: Oyebola Sonuga
Abstract
Diabetes mellitus and cardiovascular diseases significantly contribute to the medical morbidity and mortality worldwide, especially in developing countries like Nigeria. Insulin resistance, a characteristic finding of type 2 diabetics and their offspring is associated with abnormal lipid metabolism and cardiovascular disease. Aims: This study therefore aims to determine the pattern of lipid biomarkers of atherogenesis and their relationship with insulin resistance index in young people with family history of diabetes mellitus. Methods: This is a cross-sectional study carried out among 150 apparently healthy young adults between 18 to 25 years of age; 76 with family history of diabetes mellitus in first and or second degree relatives (YWFH) and 74 with no family history of diabetes mellitus (YWoFH). Anthropometric characteristics, insulin resistance index, plasma glucose, fasting lipid profile ( plasma TC, TG, HDL-C, LDL-C) and serum levels of insulin, Lp(a), ApoB, ApoA-1 and ApoB/ApoA-1 ratios were compared in the two groups and all parameters were determined using standard methods. Statistical analysis was performed using SPSS version 20.0. Results: Offspring of diabetics (YWFH) have significantly higher median BMI [p=0.015], WHR [p=0.002], IRI [p=0.038], TC [p=0.017], TG [p=0.004], Lp(a) [p=0.045], ApoB [p=0.002] and ApoB/ApoA-1 ratio [p=0.001], than their age-matched control group with no family history of diabetes mellitus (YWoFH). There is no correlation between insulin resistance index and each of the lipid biomarkers of atherogenesis except with Lp(a), with which it is negatively correlated. Conclusion: This study has demonstrated that a positive family history of type 2 diabetes mellitus is associated with higher insulin resistance index and elevated atherogenic lipid indices; thus a positive family history of diabetes mellitus in first or second degree relatives when the index person is not diabetic confirms a significant cardiovascular risk.