10^th Diabetologists Conference July 24-26,2017 Vancouver, Canada

Pediatrics is the field of medicine that is concerned with the health of infants, children, and adolescents; their growth and development; and their chance to attain full potential as adults. General medicine includes the essential treatments concerned for the betterment of pediatric health. The most significant problems can be due to nutritional deficiencies to the overall health of infants and kids as a result of growth and development is seriously hindered by shortages in essential vitamins or nutrients. The aim of the study of pediatrics is to reduce infant and child rate of deaths, management the unfold of communicable disease, promote healthy lifestyles for a long disease-free life and help ease the problems of children and adolescents. It can be acknowledged that this can be reached by learning the major and primary subject on Pediatrics.

The supervision of diabetes has been resolutely grounded in scientific advances that endure to stipulate our understanding of the pathophysiology of diabetes and direct our selection in selecting optimal therapies for type 1 and type 2 Diabetes. Common risk factors or symptoms of Diabetes include increased weight, blood pressure, cholesterol and triglyceride (blood fat) levels. The main goal of diabetes management is, as far as possible, to restore carbohydrate metabolism to a normal state. To achieve this goal, individuals with an absolute deficiency of insulin require insulin replacement therapy, which is given through injections or an insulin pump. Research on Insulin is extensively discussed in National Diabetes Conference and Diabetes associations.

The Diabetic Complications chiefly includes injurious effects of hyperglycemia which are primarily separated into macro vascular complications and micro vascular complications. Macro vascular complication chiefly includes retinopathy and micro vascular includes neuropathy. Diabetic retinopathy is also the foremost common micro vascular complication of diabetes. It is responsible for ∼ 10,000 new cases of blindness every year in the United States alone. The risk of developing diabetic retinopathy or other micro vascular complications of diabetes depends on both the duration and the severity of hyperglycemia. Diabetic nephropathy is the leading cause of renal failure in the United States. It is defined by proteinuria > 500 mg in 24 hours within the setting of diabetes; however this can be preceded by lower degrees of proteinuria, or “micro albuminuria.

Diabetic Medicare covers the fasting blood glucose test, which is a diabetes screening. Medicare covers two diabetes screenings each year for beneficiaries who are at high risk for diabetes. High risk factors for diabetes include: high blood pressure, history of abnormal sterol and triglyceride levels, obesity, or a history of high glucose. If this disorder runs in your family, you additionally may also need regular diabetes testing. Diabetic Medicare may include Therapeutic shoe, Glucose control solution or Lancet devices or Lancets as prescribed by your doctor.

Diabetic Nutrition or Diabetic diet refers to the diet that is recommended for people with diabetes mellitus, or high blood glucose. There is abundant disagreement relating to what this diet ought to accommodate. Since carbohydrate is the macronutrient which raises blood glucose levels most importantly, the greatest debate is regarding how low in carbohydrates the diet ought to be. This is because although lowering carbohydrate intake will lead to reduced blood glucose levels, but as we know it is the best source of calories too and hence one can improve the health in a big way just by making small changes to the diet, while still enjoying their favorite foods. A diabetes diet is simply a healthy eating plan that is high in nutrients, low in fat, and moderate in calories (carbohydrates too). Manufacturers are now keen towards Diabetes Nutrition on introducing new low calorie food products with sugar substitutes and less oil, in view of the increasing consumer interest toward healthy consumption and facilitate diabetes prevention and its concomitant risk factors.

The metabolism of individuals with diabetes differs to the metabolism of individuals without it. In type 2 diabetes, the effectiveness of insulin is reduced and in type 1 diabetes, insulin levels in the body are terribly low. For this reason only, type 1 diabetes requires insulin delivery from other strategies. Insulin resistance, commonest in pre-diabetes. Metabolic syndrome and type 2 diabetes, impairs the body’s ability to metabolize glucose. The metabolism of people with diabetes is sort of similar to the metabolism of people without diabetes. The sole distinction is the volume and/or effectiveness of the insulin produced by the body. There is a selected organic process by which insulin is produced inside the body of person. Insulin therapy is usually recommended for patients with type 2 diabetes mellitus and an initial A1C level greater than 9 percent.  Insulin therapy is also initiated as augmentation, beginning at 0.3 units per kg, or as replacement, beginning at 0.6 to 1.0 units per kg. Glucose control, adverse effects, cost, adherence, and quality of life ought to be thought of once selecting Medicare. Metformin should be continued if possible because it is proven to reduce all-cause mortality and cardiovascular events in overweight patients with diabetes. Titration of insulin over time is critical to improving glycemic management and preventing diabetes related complications.

The concept of and new discovery and emerging therapies like  reverse diabetes for the treatment of diabetes has expanded in recent years. There is a lot of latest research on diabetes happening and elaborated at IDF diabetes 2016 and the latest includes some very rare forms of diabetes which are caused by single gene mutations. They are called "monogenic" forms of diabetes and new research is opening the door to specific treatments for these patients. With the advanced  type1 diabetes treatment  various devices e.g. insulin pumps which is used for the administration of insulin , rapid HbA1c monitoring, insulin pen, biomarkers, biostator, artificial pancreas and etc. are formed for the treatment. Number of innovation and treatment are increasing with the increase in research work by Research and development department in various sectors and endocrinology is getting treatment with these devices. Continuous Glucose Monitoring (CGM) is a relatively new technology which has the potential to assist people living with type 1 or type 2 Diabetes and treated with insulin to achieve the goal of optimum control of blood glucose. This will remove the diabetes cholesterol.

Diabetes Drug Market has grown very rapidly over the time. The Diabetic drug sales of oral glucose- lowering treatments has increased from 10 billion USD TO 15 billion USD from 2005 to 2010 respectively, whereas the market of insulin plus analogues has made a rise to 4 billion USD from the course of 2005 to 2010 while the other drugs made increase of 1 billion USD in the same duration of time. Various companies are manufacturing different drugs for diabetic patients and the health complication caused due to it .Some of the advanced products like insulin pumps, sensors, biomarkers and Innovation seem to be the key to success because it is quite mature and without novel functionality. Tele-medicines and software’s related to increased investments in research and development segment are expected to introduce competitive pharamaceutical products  are discussed at different meetings like scientific sessions at cost effective prices in short time. This latest research on diabetes show as that the diabetes drug market segment would be filled with innovative products that would be able to offer better diabetes management which will protect from swollen pancreas  to patients. Besides all these ayurvedic and herbal medicines were also found effective for the management of Diabetes. Therefore, the various gathering are done in order to protect from metabolic diseases and these gatherings includes the world Diabetes meetings.

Clinical trials are done basically to prevent disease, to develop new and better treatments, or to find a potential cure. A clinical trial is a way to carefully test a new drug or device in patients before it is approved by the FDA to be used in the general public. Clinical trials are an important step in our being able to have new treatments for diabetes and other conditions. American Diabetes Association also provides support in the clinical trials of Diabetes. They different trials for different type of Diabetes is being run here names as TrialNet is basically to delay and reverse the process of Type 1 Diabetes, GRADE is a comparative effectiveness study looking at what medications work best at lowering blood glucose levels in patients who are newly diagnosed with diabetes, RISE (Restoring Insulin Secretion study), D2D (Vitamin D and type 2 diabetes), Accelerating medicines partnership (AMP) and FNIH biomarker Consortium. Many other associations also do diabetic trials for management of Diabetes i.e. Diabetes UK Organization etc.

There is wide research going on in the field of cure, prevention and management of Diabetes. Researchers are trying to develop therapies and drugs which should not create any side effects to the patients of Diabetes. New researches are opening the help door for patients having rare form of Diabetes too for e.g. Diabetes caused by single gene mutations which is called as “monogenic” form of diabetes. They have also created insulin patches that imitated the body’s beta cells by both sensing blood glucose level and releasing insulin. Many more researches are going on in the field of Diabetes i.e. Diabetes –depression connection, very low effort muscular activity and Diabetes risk and aerobic exercise improve brain function for people with prediabetes.

A study was done to see the combined effect of the components of energy balance (energy intake and physical activity) and the development of Type 2 Diabetes and the aim of the study is to examine the components of energy balance and the incidence of Type 2 Diabetes in a cohort of middle-aged women. This study was done on a population of 64,227 middle aged Chinese women who don’t have any prior history of Diabetes or any chronic Disease. They collected all the data on diet and physical activity habits and they found that Body Mass index (BMI) and weight gain (since age 20) was strongly associated with type 2 Diabetes incidences. They also concluded that Energy Intake (EI) was associated with modestly increased risk, while physical activity (PA) was associated with decreased risk of type 2 Diabetes, less active women with higher EI and higher risk of type 2 diabetes than active women with lower EI. The EI to PA ratio (EI:PA) was positively associated with Type 2 Diabetes risk. This study suggests that energy balance plays an important role in type 2 Diabetes and this effect may be modified by BMI.