Uzma DM Rajar
Isra University, Pakistan
Title: Compare the efficacy of olive oil with alterative (placebo) in the treatment of penile lichen planus
Biography
Biography: Uzma DM Rajar
Abstract
Objectives: Compare the efficacy of olive oil and placebo (alterative) in the topical treatment of penile lichen planus.
Methods: A randomized, double-blind, placebo (alterative)–controlled trial was designed. Thirty patients were randomized into two groups to receive olive oil or placebo for 12 weeks.
Results: Thirty consecutive male patients participated in the study. We found annular ring like patterns as a single or multiple lesions and ulcerative lesions with and without pain in 69% and 31%, respectively. The most common site of penile lichen planus was the tip of the penis. Six out of fifteen patients treated with olive oil (40%) had a good response after 12 weeks of treatment, while two of 15 alternative-treated patients (14%) had a similar response (P<0.001). Furthermore, one patient treated with olive oil (7%) had a complete clinical remission. Clinically, penile lichen planus improved by at least 40% (good response) in six patients treated with olive oil and in two patients treated with placebo (alternative) 14% (good response) (P<0.001). No side-effects were found in both groups.
Conclusions: Olive oil is significantly more effective for clinical improvement of penile lichen planus than placebo (alternative). Therefore, olive oil can be considered as a safe treatment for patients with penile lichen planus.