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Ali Al Bshabshe

Ali Al Bshabshe

King Khalid University, KSA

Title: Sepsis induced cardiomyopathy

Biography

Biography: Ali Al Bshabshe

Abstract

Sepsis induced cardiomyopathy is an entity which most of the time overlooked by the practicing intensivist although it is not uncommon and good number critically ill septic patients might suffer from. There was a high incidence of severe sepsis attended in the ICU and high ICU and hospital mortality rates. Delayed diagnosis of sepsis and progression to multi organ failure which is associated with high mortality reported in the first 48 hours of ICU admission 1. Myocardial dysfunction is one of the main predictors of poor outcome in septic patients, with mortality rates next to 70%. 2. Severe sepsis and septic shock are the main cause of death in non-cardiac Intensive Care Units (ICU), with unacceptably high mortality rates 3. One of the proposed pathological mechanisms in sepsis induced cardiomyopathy is related to mitochondrial injury and dysfunction. 4. Oxidative stress leads to energetic (and thus functional) and structural failure of the cardiomyocyte. 5. Taken together, ROS derived from NOX1/NADPH oxidase play a pivotal role in endotoxin-induced cardiomyocyte apoptosis by increasing oxidation of Akt and subsequent de-phosphorylation by PP2A. Marked up-regulation of NOX1 may affect the risk of mortality under systemic inflammatory conditions. 6. In this proposed presentation, I will review the incidence of sepsis induced cardiomyopathy along with pathogenesis and recent literature related to the topic.

Recent Publications:

  1. Blanco J, Muriel-Bombín A, Sagredo V, et al. Incidence, organ dysfunction and mortality in severe sepsis: a Spanish multicentre study. Critical Care. 2008; 12(6): R158. doi:10.1186/cc7157.
  2. Romero-Bermejo FJ, Ruiz-Bailen M, Gil-Cebrian J, Huertos-Ranchal MJ. Sepsis-induced Cardiomyopathy. Current Cardiology Reviews. 2011;7(3):163-183. doi:10.2174/157340311798220494.
  3. Annane D, Bellissant E, Cavaillon JM. Septic shock. Lancet. 2005; 365:63–78. 
  4. Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med. 2003; 348:1546–54.
  5. Tsolaki V, Makris D, Mantzarlis K, Zakynthinos E. Sepsis-Induced Cardiomyopathy: Oxidative Implications in the Initiation and Resolution of the Damage. Oxidative Medicine and Cellular Longevity. 2017; 2017:7393525. doi:10.1155/2017/7393525.
  6. Matsuno K., Iwata K., Matsumoto M., et al. NOX1/NADPH oxidase is involved in endotoxin-induced cardiomyocyte apoptosis. Free Radical Biology & Medicine. 2012;53(9):1718–1728. doi: 10.1016/j.freeradbiomed.2012.08.590.