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Athos Capuani

Athos Capuani

Private Organization Carrara, Italy

Title: New perspectives in pediatric cardiology and cardiac surgery

Biography

Biography: Athos Capuani

Abstract

Statement of the Problem: The classical congenital heart surgery in complex malformations still carries high risk and poor long term outcome despite the advances marked over the 20th century.
Hypothesis: A very early diagnosis and non invasive treatment during pregnancy on the light of the modern molecular biology would strongly affect the medical and surgical history of Congenital Heart Diseases (CHD).
Methodology: We reconsidered the embryogenesis and the morphology of the most severe CHD.
Findings: We found a common anatomical denominator in all morphological settings: the Trabecula Septomarginalis sequential malrotation counterclockwise apex-base axis (TSM, Leonardo’s cord). The TSM is composed in the normal heart by an Anterior Limb AL committed to the Outlet Septum and by a Posterior Limb PL committed to the inner curvature. Fig.1. TSM (brown) and Outlet Septum (green) rotation in sequential phenotypes from normal to Transposition of Great arteries. Fig.2. TSM rotation seen from the apex: PL green, AL Yellow. The TSM rotating follows the development of the right ventricle and is always traceable in the classical V shape or variants.
Conclusions:

  1. The TSM sequential malrotation is proposed as a model for new investigations and treatments during pregnancy.
  2. Each malformed cardiac phenotype has a specific molecular profile which can be identified by the Next Generation Sequencing analysis (NGS) and edited by the CRISPR-cas9 technique what we refer as NGS Molecular Cardiac Surgery.

          

Recent Publications:

  1. Capuani A (2017) New Perspectives in Cardiac Surgery: The Virtual Ventricle and the Molecular Cardiac Surgery. Proceedings of 7th World Congress of Pediatric Cardiology and Cardiac Surgery. Barcelona 2017,P2271:726-727. www.wcpccs2017.org.
  2. Capuani A (2016) Targeting exome sequences in congenital heart diseases: are we there yet? Proceedings of the XXXI Congress of the International Academy of Pathology and 28th Congress of the European Society of Pathology. Cologne 2016, Virchows Archiv 2016; 469(Suppl1):S1-S346 E-PS-02-003,pp s242.
  3. Capuani  A  (2015)  Potential  treatment  of  congenital  heart malformations during cardiac morphogenesis. Proceedings of the 27th European Congress of Pathology. Belgrade 2015, Virchows Archiv 2015;467(Suppl1):S1-S279 PS05-005,pp s97.
  4. Capuani A (2014) The trabecula septomarginalis (Leonardo’s cord) in abnormal ventriculo-arterial connections. J Cardiothorac Surg 2014;9:71-81.