Guo-Wei He
TEDA International Cardiovascular Hospital, China
Title: Multi-omics studies in cardiovascular diseases: Our experience
Biography
Biography: Guo-Wei He
Abstract
In the “Precision Medicine” era, integration of multiple ‘omics’ technologies will allow us to gain a more complete picture of the constituents and functions of diseases and provide far richer information for predictive modelling of phenotypes.
The multiple ‘omics’ technologies largely refer to high-throughput technologies that have revolutionized medical research. These technologies allow integrative studies at genomic, epigenomic, transcriptomic, proteomic, and metabolomic levels, etc. In cardiovascular diseases, genomics, epigenomics, transcriptomics, proteomics, and metabolomics are particularly important in understanding the mechanisms of the disease. Multi-omics offers the opportunity to understand the flow of information that underlies cardiovascular diseases better than the studies at a single omics level.
We have been using these multi-omics technologies in coronary artery disease, heart valvular diseases, and congenital heart diseases. With the multi-omics studies, we now have deeper understanding of the complexity in mechanism(s) of these diseases. This lecture will detail some of our studies as well as views on the prospects in this area.