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Luis Martinez Millan

Luis Martinez Millan

Achucarro Center for Neuroscience, Spain

Title: Geomagnetic fields produce trophic effects in myocardium

Biography

Biography: Luis Martinez Millan

Abstract

Changes of 100 degrees in the orientation of the horizontal vector of a geomagnetic field produced by three pairs of Helmholtz coils cause unanticipated alterations in the brain as well as the heart. In the rodent brain, it leads to significant cfos expression in cortical and subcortical brain structures. This expression requires neurotransmitter secretion and is mediated by the MAPKinases pathway. In the heart, autonomous and cholinergic cardiac innervations are responsible for a permanent electrical activity that makes the myocardium a receptor for magnetic fields actions. Mice submitted to the same aforementioned modified geomagnetic fields for one hour every 8 hours during a period of 10 days caused a cardiac hypertrophy. This was mainly due to a considerable increase of myocardic blood vessels distributed in both ventricles, as well as, in the intermediate and deep myocardic strata. Moreover, significant increase of cfos expression was detected in treated cases in comparison with controls. Vasculoepithelial growth factor participates in the higher density of vessels. Although these preliminary results have to be completed by studying time course, persistency and appearance after experimental myocardial infarction, it suggests the potential towards alternative clinical therapies and a translational value. The added benefit is that the magnetic apparatus is inexpensive and the envisaged application to human patients would be non-invasive.

Left pricture shows the left ventricle of a control animal and the right one shows the  left ventricle of a treated animal

Recent Publications:

  1. Actions of weak magnetic fields on signaling molecules in biological systems.  JL Zugaza, JM Barandiaran, F Zallo, D Sanchez and L Martinez Millan. 5th European Conference on Molecular Magnetism (ECMM) 6-10 September Zaragoza Spain 2015.
  2. MicroRNAs and nervous plasticity. L Martinez Millan. VI international Congress of Hstology and Tissue Engineering. 16-18 September Bilbao Spain 2015.
  3. Mechanisms involved in the gene expression changes induced by modified geomagnetic fields in encephalic neurons. L Martinez Millan, F Zallo, B Pinar, I Gerrikagoitia and JL Zugaza. 14th Meeting of the Society for Applied Neuroscience. Utrecht The Nederlands. 30th Jan-2nd Feb 2014.
  4. García Del Caño G; Gerrikagoitia I; Alonso-Cabria A; Martínez-Millán L.Organization and origin of the connection from the inferior to the superior colliculi in the rat.J Comp Neurol. 499 - 5, pp. 716 - 731. 2006.
  5. Gerrikagoitia I; Martínez-Millán L. Guanosine-Induced Synaptogenesis in the Adult Brain In Vivo. Issue The Anatomical Record.292-12,pp.1968-1975.2009.