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Telmo Pereira

Telmo Pereira

Polytechnic Institute of Coimbra, Portugal

Title: Early vascular aging (EVA) and lifestyle-based modulators (ADAM) of the vascular aging trajectory throughout life: Preliminary results of a community-based registry

Biography

Biography: Telmo Pereira

Abstract

In recent years, great emphasis has been placed on the role of arterial stiffness (AS) and central blood pressure (cBP) as measures of the cumulative effect of cardiovascular risk factors over the process of physiologic ageing. These parameters, currently labeled as arterial “tissue biomarkers”, were shown to be independent predictors for the development of cardiovascular (CV) diseases, and could thus increase the discriminative capacity when coupled to classic CV risk scores. Consequently, the assessment of AS and cBP are recommended as additional tests for the clinical evaluation of hypertensive patients (based on history, physical examination and findings from routine laboratory tests), for estimating the global cardiovascular risk in the overall population, and for describing the vascular ageing continuum.
Currently, the most widely employed methods for evaluating pulse waveforms are those based on applanation tonometry and transfer functions, although oscillometric blood pressure devices using specific algorithms for pulse wave analyses (PWA) have been proposed. At present, oscillometry is an affordable and reliable technique, and may allow a comfortable, accurate, repeated and prolonged estimation of arterial stiffness and central hemodynamics in daily life conditions, making it particular suitable for community-based follow-up intervention programmes, and for addressing the major questions underlined by the early vascular ageing (EVA) concept, namely: the validation of tissue biomarkers as surrogate end points for CV risk reduction; the determination of the predictive value of various of these arterial tissue biomarkers, and the discriminative improvement over conventional cardiovascular risk factors; the identification of effective and multidisciplinary actions to  counteract the pathophysiological processes reflected in the EVA syndrome, particularly  the aggressive decrease of atherosclerosis modifiers (ADAM). Hence, we designed a project to be implemented in a community setting based on the inter-play between Pharmacy Services, a Technology Company and a Research center, and the preliminary results will be presented.

Recent Publications:

  1. Picone DS, Schultz MG, Otahal P, Aakhus S, Al-Jumaily AM, Black JA, Bos WJ,Chambers JB, Chen CH, Cheng HM, Cremer A, Davies JE, Dwyer N, Gould BA, Hughes AD, Lacy PS, Laugesen E, Liang F, Melamed R, Muecke S, Ohte N, Okada S, Omboni S, Ott C, Peng X, Pereira T, Pucci G, Rajani R, Roberts-Thomson P, Rossen NB, Sueta  D, Sinha MD, Schmieder RE, Smulyan H, Srikanth VK, Stewart R, Stouffer GA, Takazawa K, Wang J, Westerhof BE, Weber F, Weber T, Williams B, Yamada H, Yamamoto E, Sharman JE. Accuracy of Cuff-Measured Blood Pressure: Systematic Reviews and Meta-Analyses. J Am Coll Cardiol. 2017 Aug 1;70(5):572 586.
  2. Teixeira R, Monteiro R, Baptista R, Pereira T, Ribeiro MA, Gonçalves A, Cardim N, Gonçalves L. Aortic arch mechanics measured with two dimensional speckle tracking echocardiography. J Hypertens. 2017 Jul;35(7):1402-1410.
  3. Omboni S, Posokhov IN, Parati G, Avolio A, Rogoza AN, Kotovskaya YV, Mulè G, Muiesan ML, Orlova IA, Grigoricheva EA, Cardona Muñoz E, Zelveian PH, Pereira T,  Peixoto Maldonado JM. Vascular Health Assessment of The Hypertensive Patients (VASOTENS) Registry: Study Protocol of an International, Web-Based Telemonitoring Registry for Ambulatory Blood Pressure and Arterial Stiffness. JMIR Res Protoc. 2016 Jun 29;5(2):e137. doi: 10.2196/resprot.5619.
  4. Pereira T, Pereira TS, Santos H, Correia C, Cardoso J. Arterial pulse pressure waveform monitoring by novel optical probe. Int J Cardiol. 2015 Jan 20;179:95-6.
  5. Pereira T, Santos I, Oliveira T, Vaz P, Pereira T, Santos H, Pereira H, Correia C, Cardoso J. Pulse pressure waveform estimation using distension profiling with contactless optical probe. Med Eng Phys. 2014 Nov;36(11):1515-20.
  6. Pereira T, Maldonado J, Coutinho R, Cardoso E, Laranjeiro M, Andrade I, Conde J. Invasive validation of the Complior Analyse in the assessment of central artery pressure curves: a methodological study. Blood Press Monit. 2014 Oct;19(5):280-7.
  7. Ben-Shlomo Y, Spears M, Boustred C, May M, Anderson SG, Benjamin EJ, Boutouyrie P, Cameron J, Chen CH, Cruickshank JK, Hwang SJ, Lakatta EG, Laurent S, Maldonado J, Mitchell GF, Najjar SS, Newman AB, Ohishi M, Pannier B, Pereira T, Vasan RS, Shokawa T, Sutton-Tyrell K, Verbeke F, Wang KL, Webb DJ, Willum Hansen T, Zoungas S, McEniery CM, Cockcroft JR, Wilkinson IB. Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects. J Am Coll Cardiol. 2014 Feb 25;63(7):636-46. doi: 10.1016/j.jacc.2013.09.063.