Asma Chadli
Casablanca-Hassan II University, Morocco
Title: Correlation between the plasma fibrinogen concentration and coronary heart disease severity in Moroccan patients with type 2 diabetes
Biography
Biography: Asma Chadli
Abstract
Introduction: The present study aims at determining the relationship between the plasma fibrinogen concentration and the severity of coronary heart disease in type 2 diabetic patients. Methods: Prospective analytical survey, based on a sample of 120 subjects divided in four groups: 30 diabetic coronary patients (G1), 30 coronary diabetic patients (G2), 30 non-coronary diabetic patients (G3), and 30 healthy subjects (G4). The correlation between fibrinogen and the quantitative cardiovascular risk factors (age, diabetes duration, hyperglycemia, obesity based on the body mass index (IMC>30Kg/m2), dyslipidemia manifested by low HDL cholesterol, and/or high LDL cholesterol and/or high TG; was done using Pearson’s correlation coefficient "r ". Results: The average age was 59.58±7.88 years and female gender was predominated by 52.5%. The plasma fibrinogen concentration corresponded to 3.46g/L±0.86 in G1; 3.73g/L±1.11 in G2; 3.06g/L±0.98 in G3 and 2.46g/L±0.51 in G4; significant difference with fibrinogen and the four groups (P=0.001), also with the clinical and para-clinical coronary disease severity. The correlation between fibrinogen and LDL was significant (p=0.035) in the T2D patient’s group (G3). In patients with type 2 Diabetes, the association of fibrinogen with diabetes duration was significant (p=0.036). The association of fibrinogen with both hypertension and smoking was significant in all groups; respectively (p=0.01) and (p=0.03). Conclusion: In the Moroccan population, the plasma fibrinogen concentration was positively and significantly correlated with the coronary heart disease severity.
