Day 1 :
Kyushu University, Japan
Shuzo Kumagai has completed his PhD degree from Saga Medical School, Japan. His research area includes health and exercise epidemiology for metabolic syndrome, cognitive decline, dementia, and mortality in community-dwelling population. He is a Director of Institute of Health Science (2012-2013) in Kyushu University. He is also a Chairman (1999-2011) and Chief Editor (2011-2015) of Japanese Association of Health Promotion, and Vice President (1999-2011) and Chief Editor (2006-2010) in Japanese Society of Exercise Epidemiology. He has published more than 100 papers including review paper in reputed journals
The purpose of the present study was to clarify whether the muscle fiber composition and/or muscle oxidative enzyme activity are related to dietary body weight gain and abdominal fat accumulation. Genetically fast-twitch fiber dominant rats (FFDR) and control rats (CR) were divided into low-fat or high-fat diet groups: CR with a low-fat diet (CL); CR with a high-fat diet (CH); FFDR with a low-fat diet (FL); and FFDR with a high-fat diet (FH). After 6 weeks of following such diets, the body weight gain, abdominal fat content, food intake, muscle fiber composition and oxidative enzyme activities were estimated. The body weight gain in CH was higher than in the other groups and percentage abdominal fat in CH was also higher than in the other groups, while the energy intake did not differ among the groups. The percentage of type IIX fibers of M. gastrocnemius in FL and FH were higher than in CL and CH, and the type IIA fibers of M. soleus in FL and FH were higher than in CL and CH. The citrate synthase activity of M. plantaris in FL and FH were higher than CL. β-HAD activity in FL and FH were higher than in CL and that in FH was higher than CH. On the other hand, the enzyme activities of M. gastrocnemius and soleus were identical among the groups. The FFDR was more obesity-resistant than the CR after a high-fat diet. These results suggest that the muscle oxidative capacity rather than muscle fiber composition is a possible determinant of obesity.
- Track 1:Obesity
Path Manthan is working as Associate Professor in the Australian University
Therapeutic Life Style-Change (TLC) has been a widely accepted and recognized technique to combat the modern disease of civilization. TLC diet, aerobic, anaerobic exercise, shaping, modeling, reinforcing techniques, life-style modification, information, education and communication system development are the prime interventions to fight obesity. It has been revealed that TLC technique reduce excess fat e.g. LDL, VLDL Cholesterol and Triglyceride level, and decrease cardiac mortality rate, improve cardiac efficiency, longevity and prevent stroke and their long term complications. It has been recognized that the consequence of obesity can be prevented by adopting a planned comprehensive approach. Research on traditional herbal formulation for weight loss, genetic counseling and cellular modification of non-modifiable factors are the painstaking issues to the scientific communities.
Ataturk University, Turkey
Zerrin Orbak, MD, is a graduate of Ataturk University School of Medicine, where she completed her residency in Pediatrics before going to Ege University as a Post-doctoral fellow in Pediatric Endocrinology. She has published more than 100 original articles, chapters and reviews.
Childhood is an important opportunity to develop healthy patterns for life and prevent weight problems. Children who are overweight or obese can benefit from healthy eating and regular physical activities (exercise). Children may use different methods for weight loss like adults. This study was aimed to determine methods for weight loss in children with overweight and obese. School children aged 6-16 years were included in this study. Height and weight measurements of 1695 children were evaluated and body mass index values were calculated. After that questionaire forms were given for evaluating weight loss methods. Of all children, 99 (5.8%) were overweight, 72 (4.2%) were obese and 198 (11.7%) were underweight (BMI <5 percentile). The ratios of any methods used for weight loss were 2.6%, 4.1% and 10.0% in normal, overweight and obese groups, respectively. This result was statistically significant (p<0.01). While 7.0% of overweight children, 15.0% of obese children practiced diet, exercise and alternative methods for weight loss, 2.9% of children with normal weight interestingly reported diet, exercise and alternative methods. The most common alternative methods was herbal tea (green tea, fennal tea, chamomilla, sage tea ve mix herbal tea). Normal, overweight and obese school children drunk herbal tea as 1.4%, 4.0% and 6.9%, respectively. Other methods were eating parsley, peppermint and drinking vinegar in the morning during a fast. Alternative methods were significantly frequent in obese children (p<0.001) and in older age group (11-16 age) (p<0.01). As a result the most common method was herbal teas among school children. Although effects on weight loss and adverse reactions of these methos is not described well, alternative weight loss methods are very common among overweight and obese school children even among normals. Education related to professional advice from a doctor or dietitian can help reach and maintain a healthy weight.
Chinese Academy of Medical Sciences, China
Fei Ye graduated from School of Basic Medicine, Peking University Health Science Center. She is engaged in her scientific research focusing on the pharmacology of anti-metabolic syndromes. She has published more than 40 papers, and has served as an editorial board member of Journal of International Pharmaceutical Research, and as a committee in some professional associations. She presided some items supported by National Major Project on New Drug Innovation, Natural Science Funds of China, and State Administration of Traditional Chinese Medicine, respectively. She gets 6 patents authorization about the invention of new drugs.
The animal models with the similar clinic pathophysiological characteristics provided a wonderful foundation for the investigation of diseases. The metabolic syndrome (MS) is characterized with obesity, insulin resistance, and glucolipide metabolic disorders. To establish a standardized experimental evaluation system, the euglycemic-hyperinsulinemic clamp test, insulin tolerance test (ITT), and level of whole body insulin sensitivity index（ISWB）was used for the insulin sensitivity; the hepatichistological analysis, triglyceride content, microcirculation, and serum alanine amino transferase levels were for the fatty liver; the glucose tolerance test (GTT) and serum lipid profiles were for the glucolipide metabolic disorders; and the hyperglycemic clamp test was for the islet function, respectively. The DIO mice or DIO canine were induced by the modified high-fat-diet in C57BL mice or Beagle canine (with fructose drink), respectively. Then, the metabonomics of serum, liver and urine was analyzed. As the results, the characters of gradually aggravated obesity, insulin resistance, impaired glucose tolerance, and liver lipid accumulation were similar in both DIO mice and DIO canines; but for the serum lipid profiles, DIO canine, DIO mice and KKay mice ( a classical MS model), each has their own characteristics. The characters of high-fat-diet-induced obesity animal models, DIO mice and DIO canine, are analogous with the progress of the MS patients. Acknowledgements: This work was supported by National Major Special Project on New Drug Innovation of China (No. 2012ZX09103-101-063; 2012ZX09301002) and Open Fund of State Key Laboratory of Bioactive Substance and Function of Natural Medicines (No. GTZK201512).
Vincent Chiew was graduated with Bachelor of Social Science major in Psychology minor in Business, concentration in health psychology, Carleton University, Ottawa, Canada.Vincent have 16 years of Cambridge Weight Plan business building experience with General Practioner, Slimming Center, Beauty Saloon, Gym Instructor and Individual Entrepreneur.Vincent have regularly invited by both medical and commercial organizations as speaker for bodyweight management and health awareness campaign.
Cambridge Weight Plan makes use of specially-formulated flavoured bars, soups and shakes to supply low-calorie diet ranging from about 400 to 1500 kcal or more per day. The products containing the necessary vitamins, minerals and trace elements to maintain balanced nutrition, can be used on their own as meal replacement in the very low calorie diet (VLCD) plan for fast weight lost or with (low-calorie) regular meal in the low calorie diet (LCD) plan for a more gradual weight loss or for weight maintenance. While on the program, we should also receive advice and support on healthy eating and exercise from accredited Cambridge Weight Plan Consultant. The Cambridge Weight Plan has gold-standard published clinical trials showing weight loss and weight maintenance over four years and sustained health benefits. Weight loss of 1 to 2 kg per week is possible. This can give a 15 kg weight loss, which is associated with a lessening of arthritic pain, sleep apnoea, psoriasis and better diabetes control, in 8 to 12 weeks. Weight loss of 10 kg or 10% of initial body weight (or more) can be maintained in compliant individuals. Recently, a global 8-country study (PREVIEW) on more than 2300 people with prediabetes showed that they lost an average 10.8 kg in 8 weeks on a Cambridge Weight Plan 810 kcal/d diet. This amount of weight loss can be associated with removal of ectopic fat from the liver and pancreas thereby reducing insulin resistance and improving insulin production, thus reversing prediabetes and early diabetes.
Beni-Suef University, Egypt
Sherif Sabri: This author has nothing to disclosekhalid Selim: This author has nothing to discloseHazem El-Akabawy: This author has nothing to discloseMohammad Al Ghoraieb: This author has nothing to disclose
The metabolic syndrome (MetS) is a clustering of risk factors associated with an increased risk for cardiovascular disease and type two diabetes mellitus. We aimed to identify the prevalence of MetS in patients with systolic heart failure (HF) and to determine the relation of its components to systolic HF.
A total of 100 patients with an ejection fraction 35% enrolled prospectively in this multicenter study. All recruited patients subjected to thorough history taking, clinical examination, chest Xray, electrocardiography, echocardiography, biochemical tests (fasting blood glucose, triglycerides, HDL-C, urea, creatinine, AST, ALT, & PT, T3 ,T4 ,TSH, complete blood picture, serum Na & K levels). Waist circumference; measured midway between the lower limit of the rib cage and iliac crest with nondistensible and flexible tape; was assessed in all included patients.
Metabolic syndrome was prevalent in patients with severe systolic dysfunction. Hypertension, hyperglycemia, and visceral obesity were the most common component of MetS in patients with severe systolic dysfunction HF. In males with systolic dysfunction HF, the most prevalent components of MetS were hyperglycemia (70%) followed by hypertension (67%), and visceral obesity (58%). In females with systolic dysfunction HF, the most prevalent components of MetS were hypertension (75%), hyperglycemia (56%), and visceral obesity (50%). Prevalence of MetS did not differ with age group (< 65 yrs. & 65 yrs.). Low HDL-C was significantly present in patients above 65 yrs old (72%), whereas the other MetS components did not change significantly with age. The mean number of positive MetS components was 2.6, which was not significantly different between genders or with age. There was higher prevalence of ischemic heart disease in patients with MetS (74.2%), however the rest of MetS patients (25.8%) have no ischemic heart disease (either by history, ECG, or resting Echo) in which MetS may cause heart failure by mechanisms other than ischemic heart disease.
Metabolic syndrome is prevalent in systolic dysfunction HF patients.
Asian Bariatrics Pvt.Ltd., India
Mahendra Narwaria has obtained his Post-graduate degree in General Surgery from B J Medical College, Ahmedabad in 1996. Subsequently, he pursued his interest in Surgical Gastroenterology and Laparoscopic Surgery at Sanjay Gandhi Post-graduate Institute (SGPGI), Lucknow. He is one of the pioneers of Bariatric Surgery in India and has performed more than 2000 Bariatric procedures till date. His patients have access to all possible services of Bariatric Surgery under one roof i.e., Asian Bariatrics Pvt. Ltd.
Morbid obesity is almost universally associated with non alcoholic fatty liver disease (NAFLD) and approximately half of the patients undergoing obesity surgery suffer with non alcoholic steatohepatitis (NASH). It is becoming a common cause of liver cirrhosis. Bariatric surgery can benefit obese patients with cirrhosis through weight loss and alteration of metabolic milieu as well as increase the eligibility of candidate for liver transplant. Accurate risk versus benefit analysis of each bariatric procedure in cirrhotic patients can be extremely challenging and currently there is lack of consensus among surgeons regarding safety of bariatric surgery in such patients with liver cirrhosis and the best bariatric procedure for them. The review shows an acceptably higher overall risk of complications and peri-operative mortality with bariatric surgery in cirrhotic patients. In this review, LSG and AGB appear to be safest bariatric procedure in obese patients with cirrhosis undergoing bariatric surgery. However, larger studies are needed on long term safety and efficacy of these procedures on cirrhotic patients to make clear recommendations. Surgeons must discuss the possibility of an unexpected intra-operative finding of cirrhosis preoperatively with all bariatric surgery patients and agree on a course of action to empower both patient and the surgeon.
Sam Ratulangi university, Indonesia
Aaltje E. Manampiring has completed his PhD at the age of 50 years from Hasanuddin University. She is a lecturer at faculty of Medicine Sam Ratulangi University.
Background: The prevalence of obesity is increasing in adults, adolescents and children. The increasing prevalence of obesity in the world was accompanied by an increase in the prevalence of metabolic syndrome. This study aims to determine the prevalence of obesity and metabolic syndrome in obese adolescents. Methods: This study was conducted with a cross-sectional design of high school students in North Sulawesi province of Indonesia. A total of 2248 students consisting of 865 men and 1383 women, aged 13-18 years, measurement of waist circumference (LP), blood pressure, lipid profile examination, and blood sugar levels. Subjects who are obese is the determination of the metabolic syndrome using the IDF criteria, 2007. Data were analyzed descriptively general method univariate analysis. Results: As much as 22% of subjects (494 students) are already obese centralist. From 210 obese subjects (28.9% of men and women as much as 71.1%) as much as 13.2% subject has Triglycerides ≥150 mg / dL, and as much as 81% in HDL levels below normal. 4.2% of subjects has GDP ≥100 mg / dL and 30.6% blood pressure ≥130 / 85 mmHg. The prevalence of metabolic syndrome in obese adolescents was 36.9%. Conclusion: The prevalence of adolescent obesity is 22% and 37% of obese adolescents met the criteria for metabolic syndrome. These findings may have important implications for prevention and intervention of adolescent obesity.
Sondos Harfil is a lecturer at the College of Health Sciences. Instructed several courses and memebrs in community associations and comittees. Completed her M.Sc. annd higher diploma in Biology from University of Jordan and currently enrolled in PhD program at University Sains Malaysia, Biomedicine Department. Her research interest in the field of gut mciorbiota and obesity.
Introduction: Obesity is a growing epidemic in many countries .There’s a remarkable developments in the investigation of obesity-induced insulin resistance. Low- grade inflammation is involved in the molecular mechanism of insulin resistance. Recently, the influence of changing gut microbiota has been investigated as contributing factor for obesity and metabolic aberrations. Obesity is associated with an altered gut microbiota in humans. The composition of the gut microbiota has been shown to differ in lean and obese humans and animals, and to change rapidly in response to dietary intervention. The gut microbiota may influence the development of obesity and type 2 diabetes which are characterized by low grade inflammation. These results support the emerging views that the gut microbiota contributes to metabolic disease by modulating host metabolism. Lipopolysaccharides (LPS) are released from the dead Gram-negative bacteria in the gut, and under conditions of gut damage can translocate into the circulation where it trigger an inflammatory response. LPS-binding protein (LBP) is another reactive biomarker formed in response to microbial translocation. LPS and LBP serum levels have been associated with obesity and with other cardiovascular and metabolic morbidities. There are growing evidences that the altered composition of the gut microbiota and the resulted endotoxemia are responsible for the rapid increase in obesity. Aims: The current review will discuss the recent research findings that have focused on the involvement of gut microbiota and metabolic endotoxemia in human obesity, and the potential role of dietary intervention to restore the normal gut microbiota. Conclusion: The studies indicated that the normal composition of the gut microbiota is altered with high fat diet. There are many studies that correlated the high levels of endotoxicity to low grade inflammation and the emergence of metabolic disorders and obesity.
Christian Medical College & Hospital, India
Mini Joseph is currently working as Assistant Professor in Food & Nutrition at Government College for Women, Trivandrum, Kerala. She is presently pursuing her Post-doctoral fellowship at the Department of Endocrinology, Diabetes & Metabolism, at Christian Medical College, Vellore, Tamil Nadu, India. She is recipient of Young Scientist Award from the Nutrition Society of India 2012. Her interests lie in community nutrition, energy expenditure research, sports nutrition and diabetes.
Introduction: Weightlifting is a power sport placing intense physical demands on the individual. The body composition of weightlifters is considerably different from that of other athletes.
Materials & Methods: This cross-sectional study was done on 30 selected elite professional male weightlifters in the age group of 18-28 years who were actively competing at national/international level from Vellore District in Tamil Nadu, India. The study was approved by the Institutional Review Board of Christian Medical College and Hospital, Vellore, Tamil Nadu, India. Their anthropometric measurements and body composition were assessed and analysed. All data were analysed using SPSS 16.0 for Windows.
Results & Discussions: The mean age of the participants was 21.5±2.87 years. The average duration of competitive weightlifting was 5.04±2.68 years. The mean height was 168.83±6.32 cm and mean weight was 75.95±14.73 kg. Their mean BMI indicated that they were overweight, (26.09±4.28) inspite of a low fat percentage of 15.2±5.3 9 (obtained by DXA [Hologic Delphi W (S/N 70471 DXA scanner)]. They had a high mean lean body mass of 60.9±9.2 kg indicating a well-developed musculature.
Conclusion: Thus we opine that BMI should be used as a sole tool to assess nutritional status but must be used in conjunction with the body composition to get the actual picture.